Article
Oncology
Pauline Hamon, Marine Gerbe De Thore, Marion Classe, Nicolas Signolle, Winchygn Liu, Olivia Bawa, Lydia Meziani, Celine Clemenson, Fabien Milliat, Eric Deutsch, Michele Mondini
Summary: The study reveals that Transforming growth factor-beta (TGF beta) can limit the efficacy of radiotherapy (RT) by inhibiting interferon production in macrophages, leading to immune cell exclusion. These findings suggest a potential therapeutic strategy for head and neck and lung cancer by combining TGF beta receptor inhibitors with RT.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Wenhui Shen, Peishang Shi, Qingyu Dong, Xiuman Zhou, Chunxia Chen, Xinghua Sui, Wentong Tian, Xueqin Zhu, Xiaoxi Wang, Shengzhe Jin, Yahong Wu, Guanyu Chen, Lu Qiu, Wenjie Zhai, Yanfeng Gao
Summary: A CD24/Siglec-10 blocking peptide (CSBP) was identified, which not only blocked the interaction of CD24/Siglec-10, but also PD-1/PD-L1. CSBP promoted the phagocytosis of tumor cells by macrophages and M-MDSCs, and elevated the activity of CD8(+) T cells. Furthermore, combination of CSBP and radiotherapy synergistically reduced tumor growth and altered the tumor microenvironment in both anti-PD-1-responsive MC38 and anti-PD-1-resistant 4T1 tumor models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Wilasinee Saisorn, Pornpimol Phuengmaung, Jiraphorn Issara-Amphorn, Jiradej Makjaroen, Peerapat Visitchanakun, Kritsanawan Sae-khow, Atsadang Boonmee, Salisa Benjaskulluecha, Aleksandra Nita-Lazar, Tanapat Palaga, Asada Leelahavanichkul
Summary: This study revealed the importance of O6-methylguanine-DNA methyltransferase (MGMT) in regulating lipopolysaccharide (LPS)-induced inflammation in macrophages. Silencing of mgmt resulted in reduced secretion of pro-inflammatory cytokines and expression of inflammatory genes in macrophages. Furthermore, MGMT deficiency caused macrophage injury and increased oxidative stress. The upregulation of mgmt only occurred in LPS-tolerant macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kritsanawan Sae-khow, Pornpimol Phuengmaung, Jiraphorn Issara-Amphorn, Jiradej Makjaroen, Peerapat Visitchanakun, Atsadang Boonmee, Salisa Benjaskulluecha, Tanapat Palaga, Asada Leelahavanichkul
Summary: The absence of mgmt in macrophages resulted in less severe sepsis in the cecal ligation and puncture (CLP) model. However, this protective effect was lost in mice without antibiotics, indicating the importance of microbial control during sepsis immune modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pornpimol Phuengmaung, Phuriwat Khiewkamrop, Jiradej Makjaroen, Jiraphorn Issara-Amphorn, Atsadang Boonmee, Salisa Benjaskulluecha, Patcharee Ritprajak, Aleksandra Nita-Lazar, Tanapat Palaga, Nattiya Hirankarn, Asada Leelahavanichkul
Summary: The absence of Ezh2 in macrophages resulted in less severe sepsis, indicating the importance of Ezh2 in regulating the inflammatory response. Additionally, the use of an Ezh2 inhibitor might be beneficial in severe infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Inorganic & Nuclear
Maonan Wang, Jingzhou Zhao, Hongjie Xiong, Hongbing Lu, Hui Jiang, Xuemei Wang
Summary: Tumor-associated macrophages (TAM) play a crucial role in promoting tumor growth, stimulating angiogenesis, and inhibiting the immune response. Understanding the specific role of TAM in immune escape is essential for evaluating targeted TAM therapies in the clinic. This article reviews how TAM can influence different immune cells, macrophage polarization, and the use of nano-drugs targeting TAMs, providing promising platforms for the effective treatment of various clinical immune targets in tumors.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu
Summary: Tumor-associated macrophages (TAMs) play a significant role in tumor immunotherapies, with potential therapeutic value in enhancing treatment outcomes.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Immunology
Haihong Fang, Yidong Zhang, Jiancheng Wang, Lulan Li, Sheng An, Qiaobing Huang, Zhongqing Chen, Hong Yang, Jie Wu, Zhenhua Zeng
Summary: The study demonstrated that remimazolam can attenuate inflammatory response in SALI, possibly through the activation of peripheral benzodiazepine receptors and inhibition of p38 phosphorylation in macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Yifan Tan, Min Wang, Yang Zhang, Shengyang Ge, Fan Zhong, Guowei Xia, Chuanyu Sun
Summary: Macrophages are crucial innate immune cells that can promote tumor progression in the tumor microenvironment. Targeting tumor-associated macrophages has become a significant focus in cancer therapy due to their association with cancer advancement and poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Yuhan Sheng, Baofang Zhang, Biyuan Xing, Zhao Liu, Yu Chang, Gang Wu, Yingchao Zhao
Summary: Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the tumor microenvironment play crucial roles in cancer therapy. This study investigates the interactions between TAMs and CAFs in the context of ionizing radiation (IR) and demonstrates that M2 macrophages induce radioresistance in cervical cancer. The M2 polarization of TAMs is increased after high-dose IR, which is strongly associated with CAFs. Moreover, high-dose irradiated CAFs promote macrophage M2 polarization through the secretion of chemokine (C-C motif) ligand 2 (CCL2).
Article
Multidisciplinary Sciences
Roberta De Matteis, Magdalena B. Flak, Maria Gonzalez-Nunez, Shani Austin-Williams, Francesco Palmas, Romain A. Colas, Jesmond Dalli
Summary: Inflammation is linked to colorectal cancer, and aspirin mediates its immunomodulatory effects by increasing the concentration of aspirin-triggered specialized proresolving mediators (AT-SPM) and reducing the expression of programmed cell death protein-1. These findings reveal a central role for AT-SPM in regulating inflammation-associated colorectal cancer.
Review
Oncology
Jennifer Sun, Chaelee Park, Nicole Guenthner, Shannon Gurley, Luna Zhang, Berit Lubben, Ola Adebayo, Hannah Bash, Yixuan Chen, Mina Maksimos, Barbara Muz, Abdel Kareem Azab
Summary: MM is a cancer of plasma cells in the bone marrow, with the tumor microenvironment playing a critical role in disease progression. TAMs in the TME have been found to support tumor survival and chemoresistance, highlighting the importance of exploring macrophage-targeted immunotherapy in MM treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang
Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Yuexia Xie, Huishan Li, Lei Xu, Hanbing Zou, Xingang Wang, Xiaozhen He, Qianyun Tang, Yan Zhou, Xue Zhao, Xiaojing Chen, Hongmei Liu, Jun Pu, Dan Luo, Peifeng Liu
Summary: Immunotherapy combined with radiotherapy shows potential in enhancing cancer treatment by generating a powerful abscopal effect. However, immune tolerance mechanisms in the tumor microenvironment can hinder this effect. In this study, a DNA nanocluster (DNAnc) was designed to carry CpG ODNs and repolarize macrophages, resulting in a robust abscopal effect. Mechanistic studies revealed that DNAncs were endocytosed by macrophages in the cancer tissue and induced the accumulation of repolarized macrophages, leading to potent and durable antitumor immunity, which provides a novel strategy for cancer immunotherapy enhancement.
ADVANCED MATERIALS
(2023)