Article
Biochemistry & Molecular Biology
Sarah Naguib, Carlisle R. R. DeJulius, Jon R. R. Backstrom, Ameer A. A. Haider, John M. M. Ang, Andrew M. M. Boal, David J. J. Calkins, Craig L. L. Duvall, Tonia S. S. Rex
Summary: EPO-R76E activates the NRF2/ARE pathway, leading to increased expression of antioxidant proteins and providing neuroprotection.
Article
Plant Sciences
Qing Miao, Ruihai Wang, Xiaoxin Sun, Song Du, Limei Liu
Summary: The combination of Puerarin and Tanshinone IIA can alleviate ischemic brain injury by activating the Nrf2/ARE signaling pathway, providing a basis for clinical applications.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emilia Zgorzynska, Barbara Dziedzic, Anna Walczewska
Summary: Nrf2 plays a crucial role in the expression of antioxidant and detoxifying enzymes, and dysfunctions in the Nrf2/ARE pathway can lead to various neurological pathologies. Intervention in this pathway could be a potential strategy for preventing or delaying the onset of neurodegenerative diseases. Studies have shown the beneficial effects of natural and synthetic molecules that can interact with Nrf2 to enhance its protective efficacy against oxidative stress and neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He, Ying Jia
Summary: The study revealed that Schisandra chinensis protects against dopaminergic neurodegeneration in 6-OHDA-induced Parkinson's disease mice by modulating the BDNF/Nrf2/NF-kappa B signaling pathway to suppress oxidative stress, neuroinflammation, and apoptosis.
Article
Nutrition & Dietetics
Rong Zhou, Kuan Lin, Changlong Leng, Mei Zhou, Jing Zhang, Youwei Li, Yujing Liu, Xiansheng Ye, Xiaoli Xu, Binlian Sun, Xiji Shu, Wei Liu
Summary: Chebulic acid (CA) has a neuroprotective effect against hypoxia by upregulating Nrf2 nuclear translocation, reducing oxidative damage, and improving motor ability in mice after stroke.
Article
Biochemistry & Molecular Biology
Chunyu Jiang, Fangshen Liu, Hangao Yang, Mengyue Yang, Zhanlin Li, Tong Han, Dahong Li, Huiming Hua
Summary: Plants of the Cephalotaxus genus, including Cephalotaxus oliveri, contain diverse and bioactive components. In this study, several undescribed flavonolignans and biflavonoids were isolated from C. oliveri, along with known compounds. The isolated compounds showed neuroprotective activity against H2O2-induced cell injury and umcephabiflovin B demonstrated the strongest effect.
Article
Biochemistry & Molecular Biology
Sinem Yilmaz, Erdal Bedir, Petek Ballar Kirmizibayrak
Summary: The small molecule telomerase activator Cycloastragenol (CA) has been found to have a positive impact on age-related pathophysiologies by increasing NRF2 activity, regulating telomerase activity, and enhancing proteasome activity. These findings suggest that CA plays a role in multiple cellular pathways associated with aging.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shengnan Liu, Jingbo Pi, Qiang Zhang
Summary: This review article focuses on the quantitative signaling perspective of the KEAP1-NRF2-ARE pathway and highlights the importance of signal amplification for robust induction of antioxidant genes. The study demonstrates that redox-regulated protein events in this pathway can generate highly ultrasensitive NRF2 activation and antioxidant gene induction. Understanding the signal amplification in this pathway can help identify potential targets for preventing and treating oxidative stress-related diseases and facilitate health risk assessment of oxidative chemicals.
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
ManLi Yuan, Bei Zhao, Huaping Jia, Can Zhang, Xiaowen Zuo
Summary: Sinomenine has been demonstrated to alleviate cardiac hypertrophy by activating the Nrf2/ARE signaling pathway, which leads to reduced cell area, decreased apoptosis rate, and regulation of gene and protein expression levels associated with cardiac hypertrophy. Further research is needed to confirm these findings in human subjects.
Article
Chemistry, Medicinal
Qiu-Xu Chen, Ling Zhou, Tao Long, Da-Lian Qin, Yi-Ling Wang, Yun Ye, Xiao-Gang Zhou, Jian-Ming Wu, An-Guo Wu
Summary: The study shows that galangin has the potential to treat Parkinson's disease by inhibiting neuronal degeneration through activation of the Nrf2/Keap1 signaling pathway and alleviating oxidative damage.
Article
Biochemistry & Molecular Biology
Chiara Stranieri, Flavia Guzzo, Sofia Gambini, Luciano Cominacini, Anna Maria Fratta Pasini
Summary: This study investigates the antioxidant effects of polyphenols in red wine by examining their ability to pass through cell membranes and regulate gene expression. The results show that red wine polyphenols, specifically stilbenes, flavan-3-ols derivatives, and flavonoids, can enter cells and lower reactive oxygen species induced by tert-butyl hydroperoxide. Additionally, red wine extract increases the expression of Nrf2, hemeoxygenase-1, and glutamate-cysteine ligase catalytic subunit genes in the cells.
Article
Biochemistry & Molecular Biology
Guang-Hui Chen, Chang-Chun Song, Kostas Pantopoulos, Xiao-Lei Wei, Hua Zheng, Zhi Luo
Summary: This study provides direct evidence linking mitochondrial oxidative stress and ferroptosis through the NRF2-ARE pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Yun Zhang, Maihuan Wang, Kebin Zhang, Junze Zhang, Xinpu Yuan, Guijun Zou, Zhen Cao, Chaojun Zhang
Summary: Chronic gastritis, a common digestive system disease, is mainly caused by Helicobacter pylori (H. pylori) infection. This study found that 6'-O-Galloylpaeoniflorin (GPF) can reduce H. pylori-induced gastric mucosal injury by activating the Nrf2 signaling pathway, and it has antioxidant and anti-inflammatory effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juanjuan Zhu, Hao Sun, Xinle Kang, Haixue Zhu, Xiaoteng Yan
Summary: This study verifies that acid polysaccharides from Buddleja officinalis Maxim can relieve diabetic retinopathy through inhibition of angiogenesis via activation of the Nrf2/ARE signaling pathway.
Article
Biochemistry & Molecular Biology
Seemi Tasnim Alam, Hoseong Hwang, Jong Dai Son, Uyen Tram Tu Nguyen, Jin-Soo Park, Hak Cheol Kwon, Jaeyoung Kwon, Kyungsu Kang
Summary: The extract and photosensitizer-enriched fraction of Tripterygium wilfordii showed effective antimicrobial photodynamic treatment (APDT) effects, particularly against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans. Additionally, the photosensitizers were able to induce intracellular ROS production and showed strong APDT activity against skin pathogens like Staphylococcus epidermidis and Streptococcus pyogenes. Overall, the use of TWE and TW-F5 in APDT was found to be successful in controlling pathogenic bacteria.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seung Mok Ryu, Quynh Nhu Nguyen, Sullim Lee, Haeun Kwon, Jaeyoung Kwon, Hyaemin Lee, Sun Lul Kwon, Jun Lee, Bang Yeon Hwang, Joung-han Yim, Yuanqiang Guo, Jae-Jin Kim, Ki Sung Kang, Dongho Lee
Summary: Eight new naphtho [1,2-c]furan derivatives and six known analogues were isolated from the culture medium of Basidioradulum radula, with their structures identified through spectroscopic analysis and absolute configurations resolved using various methods. Compounds 7 and 14 exhibited anti-cancer activity against human prostate cancer cells, but had no effect on the proliferation of splenocytes from immunosuppressed mice.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jaeyoung Kwon, Min Jee Kim, Dong-Cheol Kim, Haeun Kwon, Seung Mok Ryu, Sang Hee Shim, Yuanqiang Guo, Seung-Beom Hong, Joung Han Yim, Youn-Chul Kim, Hyuncheol Oh, Dongho Lee
Summary: This study identified and characterized seven spiroditerpenoids from Penicillium bialowiezense, including two new compounds. Among them, brevione A showed anti-inflammatory activity by suppressing the expression of various pro-inflammatory cytokines and mediators through inhibiting the activation of NF-κB and JNK.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jaeyoung Kwon, Hoseong Hwang, Baskar Selvaraj, Jung Hwan Lee, Woongbi Park, Seung Mok Ryu, Dongho Lee, Jin-Soo Park, Hyoung Seok Kim, Jae Wook Lee, Dae Sik Jang, Hak Cheol Kwon
Summary: The extract from Senna tora sprouts, rich in phenolic constituents, shows improved radical scavenging activities and neuroprotective effects, making it a potential natural neuroprotective agent.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Munhyung Bae, Chelsi D. Cassilly, Xiaoxi Liu, Sung-Moo Park, Betsabeh Khoramian Tusi, Xiangjun Chen, Jaeyoung Kwon, Pavel Filipcik, Andrew S. Bolze, Zehua Liu, Hera Vlamakis, Daniel B. Graham, Sara J. Buhrlage, Ramnik J. Xavier, Jon Clardy
Summary: This study identifies a lipid molecule from Akkermansia muciniphila's cell membrane that exhibits immunomodulatory activity through the Toll-like receptor TLR2-TLR1 pathway. The findings provide molecular insights into the role of Akkermansia muciniphila in regulating immune balance and its impact on health and disease.
Article
Plant Sciences
Jaeyoung Kwon, Kyerim Lee, Hoseong Hwang, Seong-Hwan Kim, Se Eun Park, Prasannavenkatesh Durai, Keunwan Park, Hyung-Seop Kim, Dae Sik Jang, Jae Sue Choi, Hak Cheol Kwon
Summary: Algae are unique natural products that can produce various types of biologically active compounds. A study found that a certain type of monocyclic terpenoid lactone extracted from brown algae showed potential inhibition of human monoamine oxidases, making it a potential lead compound for the treatment of psychiatric or neurological diseases.
Article
Plant Sciences
Haeun Kwon, Quynh Nhu Nguyen, Seung Mok Ryu, Jaeyoung Kwon, Sojung Park, Yuanqiang Guo, Bang Yeon Hwang, Joung Han Yim, Jae-Jin Kim, Ki Sung Kang, Dongho Lee
Summary: This study discovered biologically active compounds from the extract of Neopestalotiopsis clavispora culture medium and identified a new compound called hymenosetin that showed estrogenic activity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Eun-Ji Park, Keunwan Park, Prasannavenkatesh Durai, Ki-Young Kim, So-Young Park, Jaeyoung Kwon, Hee Ju Lee, Cheol-Ho Pan, Kwang-Hyeon Liu
Summary: Obtusifolin, a major anthraquinone component in Cassia tora seeds, has been shown to have various biological activities. This study evaluated the inhibitory effects of obtusifolin and its analogs on CYP1A enzymes and investigated their inhibitory mechanism and chemopreventive effects. The results showed that obtusifolin selectively inhibited CYP1A2 activity and exhibited potential chemopreventive effects.
Article
Biochemistry & Molecular Biology
Hoseong Hwang, Dahae Lee, Jong Dai Son, Jong Gwon Baek, Hyeon-Seong Lee, InWha Park, Dong Hoon Kim, Soon Kwang Lee, Won Kyu Kim, Hak Cheol Kwon, Ki Sung Kang, Jaeyoung Kwon
Summary: In this study, 13 compounds, including three new monoterpenoids, were isolated from the leaves of Actinidia polygama. The structures of these compounds were characterized and their potential bioactivities were investigated. Two compounds, 3-O-coumaroylmaslinic acid and jacoumaric acid, showed insulin secretion activity and alpha-glucosidase inhibitory activity. Furthermore, they increased the expression of insulin-related proteins and may be developed as potential antidiabetic agents.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jaeyoung Kwon, Munhyung Bae, David Szamosvari, Chelsi D. Cassilly, Andrew S. Bolze, David R. Jackson, Ramnik J. Xavier, Jon Clardy
Summary: Some members of the human gut microbiota have significant impact on the host's physiology, health, and therapeutic responses, but the specific molecules and mechanisms responsible are not well understood. As part of a research project, the metabolome of Collinsella aerofaciens, a commonly studied actinobacterium, was analyzed to identify immune-regulating compounds produced by gut microbes. The active compound, CaLGL-1, a lysoglycoglycerolipid, was identified and its production was found to be dependent on TLR2 signaling.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Yujin Kwon, Jiyoon Kim, Su-Yeon Cho, Yoon Jin Kang, Jongsoo Lee, Jaeyoung Kwon, Hyungjin Rhee, Sebastian Bauer, Hyung-Sik Kim, Esak Lee, Han Sang Kim, Jae Hung Jung, Hoguen Kim, Won Kyu Kim
Summary: Gastrointestinal stromal tumors (GISTs) frequently show KIT mutations, leading to overexpression and abnormal localization of mutant KIT (MT-KIT). BLZF1 was identified as a novel binding partner of MT-KIT, anchoring it to the Golgi complex. The sustained activation of ATF6, a member of the unfolded protein response (UPR) family, helps in MT-KIT folding and relieves endoplasmic reticulum (ER) stress. The activation of ATF6 is frequently observed in GIST patients and is significantly associated with poorer relapse-free survival.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Food Science & Technology
Ngoc Minh Ha, Hoseong Hwang, Seemi Tasnim Alam, Uyen Tran Tu Nguyen, Soon Kwang Lee, Jin-Soo Park, Jin-Chul Kim, Hak Cheol Kwon, Jaeyoung Kwon, Kyungsu Kang
Summary: This study evaluated the antibacterial properties of antimicrobial photodynamic therapy combined with L. fischeri extract against MRSA and various pathogens, and assessed its photopharmaceutical actions in C. elegans. The results showed that this therapy effectively inhibited the growth of pathogens and improved the quality of life and lifespan in MRSA-infected worms without causing severe side effects. These findings highlight the significance of this treatment for safe MRSA phototreatment in biomedical and cosmeceutical industries.
APPLIED BIOLOGICAL CHEMISTRY
(2023)
Article
Integrative & Complementary Medicine
Saruul Erdenebileg, Yang-Ju Son, Myungsuk Kim, Sarangerel Oidovsambuu, Kwang Hyun Cha, Jaeyoung Kwon, Da Seul Jung, Chu Won Nho
Summary: The root extract of S. divaricata showed potential in treating IBD by reducing inflammatory cytokine levels and altering gut microbiota composition.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Article
Allergy
Yujin Kwon, Yoon Jin Kang, Jaeyoung Kwon, Su-Yeon Cho, Jiyoon Kim, Tam Thi Le, Hoseong Hwang, Barsha Deshar, Myungjun Kim, Ju Yeong Kim, Jae Hung Jung, Hyung-Sik Kim, Sang Hoon Jung, Hak Cheol Kwon, Won Kyu Kim
Summary: Forsythia velutina Nakai extract and its compounds demonstrate promising efficacy for prolonged atopic dermatitis treatment by independently inhibiting various cell types associated with AD and disrupting the deleterious link between them.
Article
Biochemistry & Molecular Biology
Yujin Kwon, Su-Yeon Cho, Jaeyoung Kwon, Min Hwang, Hoseong Hwang, Yoon Jin Kang, Hyeon-Seong Lee, Jiyoon Kim, Won Kyu Kim
Summary: The treatment of atopic dermatitis (AD) is challenging due to its complex etiology. This study identified a plant extract (PE) with anti-inflammatory effects on multiple cell types involved in AD development. The PE suppressed degranulation and cytokine production, regulated FceRI and TLR4 signaling, and improved skin structure in an AD mouse model. The findings suggest that this PE could be a potential treatment for AD.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
