The opioid system and the social brain: implications for depression and suicide

Epigenetic regulation of the kappa opioid receptor gene by an insertion–deletion in the promoter region

(2018) Pierre-Eric Lutz et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Catalytic activation of β-arrestin by GPCRs

(2018) Kelsie Eichel et al.   NATURE

Molecular mechanism of GPCR-mediated arrestin activation

(2018) Naomi R. Latorraca et al.   NATURE

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

(2018) Miriam Stoeber et al.   NEURON

Opioidergic regulation of pain and pleasure in human social relationships

(2018) Lauri Nummenmaa et al.   NEUROPSYCHOPHARMACOLOGY

Focusing on the Opioid System for Addiction Biomarker Discovery

(2018) Raoul Belzeaux et al.   TRENDS IN MOLECULAR MEDICINE

The salience of self, not social pain, is encoded by dorsal anterior cingulate and insula

(2018) Irene Perini et al.   Scientific Reports

Reversal of Stress-Induced Social Interaction Deficits by Buprenorphine

(2017) Caroline A Browne et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Oxytocin and Serotonin Brain Mechanisms in the Nonhuman Primate

(2017) Arthur Lefevre et al.   JOURNAL OF NEUROSCIENCE

Social Laughter Triggers Endogenous Opioid Release in Humans

(2017) Sandra Manninen et al.   JOURNAL OF NEUROSCIENCE

Neuropathology of suicide: recent findings and future directions

(2017) P-E Lutz et al.   MOLECULAR PSYCHIATRY

Functional selectivity of GPCR-directed drug action through location bias

(2017) Roshanak Irannejad et al.   Nature Chemical Biology

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

(2017) Gregory Corder et al.   NATURE MEDICINE

Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula

(2017) Daniel C. Castro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

(2017) Eiluned Pearce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interpersonal theory of suicide: A systematic review and meta-analysis of a decade of cross-national research.

(2017) Carol Chu et al.   PSYCHOLOGICAL BULLETIN

Suicidal Ideation and Suicide Attempts in the Elderly Associated with Opioid Use and Pain Sensitivity

(2017) Raffaella Calati et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

The Neurobiology of Human Attachments

(2017) Ruth Feldman   TRENDS IN COGNITIVE SCIENCES

Social pain and social gain in the adolescent brain: A common neural circuitry underlying both positive and negative social evaluation

(2017) Tim Dalgleish et al.   Scientific Reports

The experience of social exclusion in women with a history of suicidal acts: a neuroimaging study

(2017) Emilie Olié et al.   Scientific Reports

Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse

(2017) Pierre-Eric Lutz et al.   BIOLOGICAL PSYCHIATRY

Opioid Modulation With Buprenorphine/Samidorphan as Adjunctive Treatment for Inadequate Response to Antidepressants: A Randomized Double-Blind Placebo-Controlled Trial

(2016) Maurizio Fava et al.   AMERICAN JOURNAL OF PSYCHIATRY

Social support and protection from depression: systematic review of current findings in Western countries

(2016) Geneviève Gariépy et al.   BRITISH JOURNAL OF PSYCHIATRY

Is there heightened sensitivity to social reward in adolescence?

(2016) Lucy Foulkes et al.   CURRENT OPINION IN NEUROBIOLOGY

Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials

(2016) William A. Carlezon et al.   DEPRESSION AND ANXIETY

Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors

(2016) Edgardo Falcon et al.   NEUROPSYCHOPHARMACOLOGY

Divergent relationship of depression severity to social reward responses among patients with bipolar versus unipolar depression

(2016) Anup Sharma et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

A meta-analytic review of the association between perceived social support and depression in childhood and adolescence.

(2016) Sandra Yu Rueger et al.   PSYCHOLOGICAL BULLETIN

Opioids and social bonding: naltrexone reduces feelings of social connection

(2016) Tristen K. Inagaki et al.   Social Cognitive and Affective Neuroscience

Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

(2016) Shanna L Resendez et al.   eLife

Brain imaging of pain: state of the art

(2016) Debbie Morton et al.   Journal of Pain Research

Decreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides

(2015) Pierre-Eric Lutz et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Adult attachment style is associated with cerebral μ-opioid receptor availability in humans

(2015) Lauri Nummenmaa et al.   HUMAN BRAIN MAPPING

Possible role of a dysregulation of the endogenous opioid system in antisocial personality disorder

(2015) Borwin Bandelow et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Social Reward in Youth at Risk for Depression: A Preliminary Investigation of Subjective and Neural Differences

(2015) Thomas M. Olino et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Discriminating neural representations of physical and social pains: how multivariate statistics challenge the “shared representation” theory of pain

(2015) A. Rogachov et al.   JOURNAL OF NEUROPHYSIOLOGY

Mouse Model of OPRM1 (A118G) Polymorphism Increases Sociability and Dominance and Confers Resilience to Social Defeat

(2015) L. A. Briand et al.   JOURNAL OF NEUROSCIENCE

It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder

(2015) D T Hsu et al.   MOLECULAR PSYCHIATRY

Spatiotemporal Control of Opioid Signaling and Behavior

(2015) Edward R. Siuda et al.   NEURON

The role of endogenous opioids in non-suicidal self-injurious behavior: Methodological challenges

(2015) Olivia J. Kirtley et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Placebo analgesia and its opioidergic regulation suggest that empathy for pain is grounded in self pain

(2015) Markus Rütgen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association Between Social Integration and Suicide Among Women in the United States

(2015) Alexander C. Tsai et al.   JAMA Psychiatry

Naltrexone vs Placebo for the Treatment of Alcohol Dependence

(2015) David W. Oslin et al.   JAMA Psychiatry

Why Social Pain Can Live on: Different Neural Mechanisms Are Associated with Reliving Social and Physical Pain

(2015) Meghan L. Meyer et al.   PLoS One

Evaluation of Opioid Modulation in Major Depressive Disorder

(2014) Elliot Ehrich et al.   NEUROPSYCHOPHARMACOLOGY

Autistic-Like Syndrome in Mu Opioid Receptor Null Mice is Relieved by Facilitated mGluR4 Activity

(2014) Jérôme AJ Becker et al.   NEUROPSYCHOPHARMACOLOGY

OPRM1 polymorphism and lifetime suicide attempts among stabilized, methadone-maintained outpatients

(2014) R. Icick et al.   PSYCHIATRY RESEARCH

Endogenous opioid system influences depressive reactions to socially painful targeted rejection life events

(2014) George M. Slavich et al.   PSYCHONEUROENDOCRINOLOGY

Separate neural representations for physical pain and social rejection

(2014) Choong-Wan Woo et al.   Nature Communications

Physical and Social Pains in Borderline Disorder and Neuroanatomical Correlates: A Systematic Review

(2014) Déborah Ducasse et al.   Current Psychiatry Reports

Association of In Vivo κ-Opioid Receptor Availability and the Transdiagnostic Dimensional Expression of Trauma-Related Psychopathology

(2014) Robert H. Pietrzak et al.   JAMA Psychiatry

The Kappa Opioid Receptor: From Addiction to Depression, and Back

(2014) Laurence Lalanne et al.   Frontiers in Psychiatry

The multiple facets of opioid receptor function: implications for addiction

(2013) Pierre-Eric Lutz et al.   CURRENT OPINION IN NEUROBIOLOGY

Social ties and health: a social neuroscience perspective

(2013) Naomi I Eisenberger   CURRENT OPINION IN NEUROBIOLOGY

 -Opioid Receptors within Subregions of the Striatum Mediate Pair Bond Formation through Parallel Yet Distinct Reward Mechanisms

(2013) S. L. Resendez et al.   JOURNAL OF NEUROSCIENCE

Response of the μ-opioid system to social rejection and acceptance

(2013) D T Hsu et al.   MOLECULAR PSYCHIATRY

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

(2013) Gül Dölen et al.   NATURE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

The nucleus accumbens is involved in both the pursuit of social reward and the avoidance of social punishment

(2013) Gregor Kohls et al.   NEUROPSYCHOLOGIA

Delta opioid receptors in brain function and diseases

(2013) Paul Chu Sin Chung et al.   PHARMACOLOGY & THERAPEUTICS

Pain and suicidality: Insights from reward and addiction neuroscience

(2013) Igor Elman et al.   PROGRESS IN NEUROBIOLOGY

History of Suicidal Behaviour and Analgesic Use in Community-Dwelling Elderly

(2013) Emilie Olié et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Aversive motivation and the maintenance of monogamous pair bonding

(2013) Shanna L. Resendez et al.   REVIEWS IN THE NEUROSCIENCES

A Quantitative Meta-Analysis of Functional Imaging Studies of Social Rejection

(2013) Stephanie Cacioppo et al.   Scientific Reports

Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons

(2013) M. S. Mazei-Robison et al.   Cold Spring Harbor Perspectives in Medicine

Mu opioid receptor availability in people with psychiatric disorders who died by suicide: a case control study

(2012) Elizabeth Scarr et al.   BMC Psychiatry

Neuroscience of human social interactions and adult attachment style

(2012) Pascal Vrtička et al.   Frontiers in Human Neuroscience

Genetic–epigenetic interaction modulates µ-opioid receptor regulation

(2012) Bruno G. Oertel et al.   HUMAN MOLECULAR GENETICS

 -Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance

(2012) S. L. Resendez et al.   JOURNAL OF NEUROSCIENCE

Neural mechanisms of social risk for psychiatric disorders

(2012) Andreas Meyer-Lindenberg et al.   NATURE NEUROSCIENCE

The pain of social disconnection: examining the shared neural underpinnings of physical and social pain

(2012) Naomi I. Eisenberger   NATURE REVIEWS NEUROSCIENCE

Modulation of nociception by social factors in rodents: contribution of the opioid system

(2012) Francesca R. D’Amato et al.   PSYCHOPHARMACOLOGY

Opioid receptors: distinct roles in mood disorders

(2012) Pierre-Eric Lutz et al.   TRENDS IN NEUROSCIENCES

Nucleus Accumbens  -Opioid Receptors Mediate Social Reward

(2011) V. Trezza et al.   JOURNAL OF NEUROSCIENCE

Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction

(2011) Michael R. Bruchas et al.   NEURON

Child μ-Opioid Receptor Gene Variant Influences Parent–Child Relations

(2011) William E Copeland et al.   NEUROPSYCHOPHARMACOLOGY

Endogenous opiates and behavior: 2010

(2011) Richard J. Bodnar   PEPTIDES

Decreased response to social defeat stress in μ-opioid-receptor knockout mice

(2011) Hiroshi Komatsu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuronal circuits underlying acute morphine action on dopamine neurons

(2011) M. Jalabert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation in the μ-opioid receptor gene (OPRM1) moderates the influence of early maternal care on fearful attachment

(2011) Alfonso Troisi et al.   Social Cognitive and Affective Neuroscience

Dysregulation of Regional Endogenous Opioid Function in Borderline Personality Disorder

(2010) Alan R. Prossin et al.   AMERICAN JOURNAL OF PSYCHIATRY

OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models

(2010) Stephen D. Mague et al.   DRUG AND ALCOHOL DEPENDENCE

Central modulation of pain

(2010) Michael H. Ossipov et al.   JOURNAL OF CLINICAL INVESTIGATION

The interpersonal theory of suicide.

(2010) Kimberly A. Van Orden et al.   PSYCHOLOGICAL REVIEW

Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients

(2010) Alfonso Troisi et al.   Social Neuroscience

The pleasures of play: pharmacological insights into social reward mechanisms

(2010) Viviana Trezza et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

From the neuromatrix to the pain matrix (and back)

(2010) G. D. Iannetti et al.   EXPERIMENTAL BRAIN RESEARCH

Non-suicidal self-injurious behavior, endogenous opioids and monoamine neurotransmitters

(2009) Barbara Stanley et al.   JOURNAL OF AFFECTIVE DISORDERS

Reward Processing by the Opioid System in the Brain

(2009) Julie Le Merrer et al.   PHYSIOLOGICAL REVIEWS

Variation in the  -opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

(2009) B. M. Way et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A functional polymorphism of the µ-opioid receptor gene is associated with completed suicides

(2008) A. Hishimoto et al.   JOURNAL OF NEURAL TRANSMISSION

Opioid receptors: From binding sites to visible molecules in vivo

(2008) Brigitte L. Kieffer et al.   NEUROPHARMACOLOGY

Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates

(2008) Christina S. Barr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA