Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

Neuroprotective Effects of Luteolin Against Spinal Cord Ischemia–Reperfusion Injury by Attenuation of Oxidative Stress, Inflammation, and Apoptosis

(2018) Jian Fu et al.   JOURNAL OF MEDICINAL FOOD

The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia

(2018) Rebeca Vecino et al.   Scientific Reports

Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis

(2018) Ya-Ni Huang et al.   Scientific Reports

New Light on An Old Friend: Targeting PUMA in Radioprotection and Therapy of Cardiovascular and Neurodegenerative Diseases

(2018) Ales Tichy et al.   CURRENT DRUG TARGETS

The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function

(2017) Jaeda C. Coutinho-Budd et al.   GENES & DEVELOPMENT

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

(2017) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway

(2017) Xiao-Qian Li et al.   Journal of Neuroinflammation

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

(2016) C Turnquist et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22

(2016) Hui Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeting the blood-spinal cord barrier: A therapeutic approach to spinal cord protection against ischemia-reperfusion injury

(2016) Ji Hu et al.   LIFE SCIENCES

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Simultaneous assessment of NF-κB/p65 phosphorylation and nuclear localization using imaging flow cytometry

(2015) Orla Maguire et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Insulin Receptor Substrate-1 Activation Mediated p53 Downregulation Protects Against Hypoxic-Ischemia in the Neonatal Brain

(2015) Yi-Fang Tu et al.   MOLECULAR NEUROBIOLOGY

PUMA is invovled in ischemia/reperfusion-induced apoptosis of mouse cerebral astrocytes

(2015) H. Chen et al.   NEUROSCIENCE

Caught in the cross fire: p53 in inflammation

(2014) Tomer Cooks et al.   CARCINOGENESIS

Structural Basis for Phosphorylation and Lysine Acetylation Cross-talk in a Kinase Motif Associated with Myocardial Ischemia and Cardioprotection

(2014) Benjamin L. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke

(2014) Pawel J Winklewski et al.   Journal of Neuroinflammation

Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration

(2014) Joseph Jebelli et al.   NEUROSCIENCE LETTERS

New insights into p53 functions through its target microRNAs

(2014) J.-M. Liao et al.   Journal of Molecular Cell Biology

Sevoflurane preconditioning ameliorates neuronal deficits by inhibiting microglial MMP-9 expression after spinal cord ischemia/reperfusion in rats

(2014) Xiao-Qian Li et al.   Molecular Brain

Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood–spinal cord barrier following ischemia/reperfusion injury in rats

(2014) Xiao-Qian Li et al.   Molecular Brain

Ischemic Preconditioning Protects against Spinal Cord Ischemia-Reperfusion Injury in Rabbits by Attenuating Blood Spinal Cord Barrier Disruption

(2013) Bo Fang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro binding properties of tumor suppressor p53 with PUMA and NOXA

(2012) So Young Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory Effect of p53 Upregulated Modulator of Apoptosis Targeting siRNA on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis in Rats

(2012) Shuo Tu et al.   CARDIOLOGY

Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1

(2011) Gu Gong et al.   ACTA PHARMACOLOGICA SINICA

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

p53-mediated neuronal cell death in ischemic brain injury

(2010) Li-Zhi Hong et al.   Neuroscience Bulletin

Potential Role of PUMA in Delayed Death of Hippocampal CA1 Neurons After Transient Global Cerebral Ischemia

(2008) Kuniyasu Niizuma et al.   STROKE