Review
Cell Biology
Feng-Shou Chen, Xiang-Yi Tong, Bo Fang, Dan Wang, Xiao-Qian Li, Zai-Li Zhang
Summary: This review summarizes the relationship between miRNAs and spinal cord ischemia/reperfusion injury, as well as potential therapeutic strategies, which is of great significance for the research of spinal cord ischemia/reperfusion injury.
NEURAL REGENERATION RESEARCH
(2022)
Article
Immunology
Shutian Zhang, Yufeng Yan, Yongze Wang, Zhaodong Sun, Chengzhi Han, Xinyi Qian, Xiaorong Ren, Yi Feng, Jian Cai, Chunmei Xia
Summary: This study demonstrated that inhibiting MALT1 can modulate glial endoplasmic reticulum stress and alleviate neuroinflammation in spinal cord ischemia/reperfusion injury, suggesting a potential therapeutic target for this condition.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Medicine, Research & Experimental
Bo Xu, Jiaqi Fang, Jianguang Wang, Xuehan Jin, Shengfu Liu, Kaihang Song, Ping Wang, Junjian Liu, Shuhao Liu
Summary: This study investigated the protective effect of edaravone on blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). The results showed that edaravone treatment promoted functional recovery, improved vascular damage, and up-regulated BSCB-associated proteins in rats with SCI. In vitro experiments also demonstrated that edaravone improved cell viability, restored intercellular junctions, and promoted angiogenic activities. The underlying mechanism may involve the improvement of autophagy and the phosphorylation of RIP1/RIP3/MLKL. Overall, edaravone can be a potential treatment option for SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Zhou Feng, Lingxia Min, Liang Liang, Beike Chen, Hui Chen, Yi Zhou, Weiwei Deng, Hongliang Liu, Jingming Hou
Summary: It has been discovered that infiltrated neutrophils in spinal cord injury produce NETs, promoting neuroinflammation and blood-spinal cord barrier disruption, exacerbating SCI. Inhibition or disruption of NETs formation can alleviate damage and promote functional recovery after SCI.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Li Deng, Jun Qiao Lv, Lin Sun
Summary: This study systematically analyzed the experimental treatments and their mechanisms for reducing blood spinal cord barrier (BSCB) injury in the early stage of traumatic spinal cord injury (t-SCI). BMSC-Exos, which inhibit matrix metalloproteinases (MMPs) expression, are currently the most effective therapeutic modality for alleviating BSCB damage. In addition, the regulation of MMPs, the Akt pathway, and the ER stress pathway play important roles in alleviating BSCB injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Guang Kong, Wu Xiong, Cong Li, Chenyu Xiao, Siming Wang, Wenbo Li, Xiangjun Chen, Juan Wang, Sheng Chen, Yongjie Zhang, Jun Gu, Jin Fan, Zhengshuai Jin
Summary: This study explores the influence of Treg cells on the recovery of BSCB after spinal cord injury (SCI) and its underlying mechanism. The findings suggest that Treg cell-derived exosomes can affect BSCB integrity and motor function by regulating the expression of IRAK1. This provides novel insights for functional repair and inflammation limitation after SCI.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Immunology
Rubing Zhou, Junzhao Li, Zhengyang Chen, Ruideng Wang, Yin Shen, Rong Zhang, Fang Zhou, Yong Zhang
Summary: Blood-spinal cord barrier (BSCB) disruption is a crucial event in spinal cord injury (SCI), allowing harmful substances to enter neural tissue and exacerbate secondary damage. The mechanisms of BSCB disruption in the acute phase of SCI remain unclear, leading to a lack of effective clinical treatment strategies.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Engineering, Biomedical
Xin Wang, Baokun Zhang, Zhiheng Chen, Qiang Shi, Erzhu Yang, Jianguang Xu, Xiaofeng Lian
Summary: Following spinal cord injury, the disruption of the blood-spinal cord barrier (BSCB) and hemorrhage lead to progressive secondary injuries. Bazedoxifene, a third-generation estrogen receptor modulator, has been found to inhibit inflammation and blood-brain barrier disruption caused by traumatic brain injury. In this study, a new biomaterial carrier was developed to deliver Bazedoxifene to the site of spinal cord injury and effectively attenuate BSCB disruption through the NF-KB pathway, providing potential therapeutic benefits for spinal cord repair.
ACTA BIOMATERIALIA
(2023)
Review
Biology
Shuo Li, Hoai Thi Phuong Dinh, Yukihiro Matsuyama, Kohji Sato, Satoru Yamagishi
Summary: Traumatic spinal cord injury (SCI) causes physical impairment and psychological devastation through complex pathological processes. The two phases of SCI include primary mechanical damage and secondary injury, which lead to vascular disruption, inflammation, cell death, and scar formation. Secretory factors, such as neurotrophic factors and growth factors, play important roles in nerve regeneration, while the blood-spinal cord barrier (BSCB) is damaged, allowing immune cell infiltration and promoting angiogenesis. This review discusses the therapeutic application and outcomes of these secretory factors in SCI.
Article
Neurosciences
Zhenxin Hu, Tingting Wu, Ziheng Zhou, Yu Zhang, Qiyue Chen, Hanbing Yao, Mengchu Ji, Ge Shen, Chenling Dong, Chengge Shi, Zhixian Huang, Nizhou Jiang, Nan Han, Xiliang Tian
Summary: This study aimed to investigate the effect of asiaticoside on pericytes and the blood-spinal cord barrier (BSCB). The results showed that asiaticoside could inhibit BSCB disruption and enhance functional recovery after spinal cord injury (SCI).
MOLECULAR NEUROBIOLOGY
(2023)
Review
Endocrinology & Metabolism
Rubing Zhou, Junzhao Li, Ruideng Wang, Zhengyang Chen, Fang Zhou
Summary: The neurovascular unit (NVU) represents the close relationship between neurons and blood vessels. However, our understanding of NVU in the spinal cord is limited, and mainly based on knowledge from the brain. In this review, we summarize the current knowledge of NVU and discuss potential approaches to study NVU in the spinal cord. Several unique features maintain the regulated microenvironment in the NVU. Autoregulation and neurovascular coupling ensure proper blood flow based on metabolic demand and neural activation. The blood-central nervous system barrier separates circulating blood from the neural tissue and allows selective exchange of substances. We also discuss the implications of NVU dysfunction in spinal cord injury. This review aims to enhance our understanding of NVU in the spinal cord and provide insights into spinal cord injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Schepici, Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury (SCI) is a devastating condition that causes permanent motor and sensory deficits. Researchers have been studying potential therapeutic strategies to mitigate the neuro-inflammatory response following injury. Recent studies have shown that exosomes-derived MSCs (MSC-EXOs) have promising effects as an innovative therapy for SCI patients.
Article
Biochemistry & Molecular Biology
Guohui Yang, Pengfei Yao, Shengli Ma, Chi Zhang
Summary: In rats with spinal cord ischemic injury, levels of bradykinin and B2 receptors were decreased. Bradykinin treatment significantly improved motor function, reduced inflammatory mediators, and activated B2 receptors, suggesting a potential mechanism for improving hind limb recovery.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Immunology
Chenxi Zhao, Tiangang Zhou, Xiaoqing Zhao, Yilin Pang, Wenxiang Li, Baoyou Fan, Ming Li, Xinjie Liu, Lei Ma, Jiawei Zhang, Chao Sun, Wenyuan Shen, Xiaohong Kong, Xue Yao, Shiqing Feng
Summary: This study provides preclinical information on the administration time window of 2-12 h post-injury for nafamostat in contusive SCI. It reveals that nafamostat functions by inhibiting thrombin-mediated BSCB breakdown and subsequent infiltration of peripheral immune cells.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.