Stroke Neuroprotection: Oestrogen and Insulin-Like Growth Factor-1 Interactions and the Role of Microglia

Estrogen receptors and ischemic neuroprotection: Who, what, where, and when?

(2013) Derek A. Schreihofer et al.   BRAIN RESEARCH

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

(2013) Hyeon-Sook Suh et al.   Journal of Neuroinflammation

Aging enhances classical activation but mitigates alternative activation in the central nervous system

(2013) Daniel C. Lee et al.   NEUROBIOLOGY OF AGING

Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis

(2013) Wan-fu Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model

(2012) Mami Fukunaga Kawamura et al.   EXPERIMENTAL NEUROLOGY

Relationship Between the Neuroprotective Effects of Insulin-Like Growth Factor-1 and 17β-Oestradiol in Human Neuroblasts

(2012) P. Luciani et al.   JOURNAL OF NEUROENDOCRINOLOGY

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes

(2012) Miklós Sárvári et al.   Journal of Neuroinflammation

Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury

(2012) M. Lalancette-Hebert et al.   JOURNAL OF NEUROSCIENCE

Gonadal steroids prevent cell damage and stimulate behavioral recovery after transient middle cerebral artery occlusion in male and female rats

(2011) Jon Dang et al.   BRAIN BEHAVIOR AND IMMUNITY

Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice

(2011) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

Whole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia–ischemia

(2011) Shuying Lin et al.   BRAIN RESEARCH

Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages

(2011) Tatsuhiro Nakata et al.   BRAIN RESEARCH

An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

(2011) Kaoru Saijo et al.   CELL

Effects of Estradiol and IGF-1 on the Sodium Calcium Exchanger in Rat Cultured Cortical Neurons

(2011) Julio C. Sánchez et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence

(2011) Han Yan et al.   JOURNAL OF ENDOCRINOLOGY

Selective Oestrogen Receptor Modulators Decrease the Inflammatory Response of Glial Cells

(2011) M. A. Arevalo et al.   JOURNAL OF NEUROENDOCRINOLOGY

Insulin-Like Growth Factor I Signaling for Brain Recovery and Exercise Ability in Brain Ischemic Rats

(2011) HENG-CHIH CHANG et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?

(2011) Elke Verena Voß et al.   NEUROBIOLOGY OF DISEASE

Spatial and Temporal Profiles of Growth Factor Expression during CNS Demyelination Reveal the Dynamics of Repair Priming

(2011) Viktoria Gudi et al.   PLoS One

Neuronal Estrogen Receptor-α Mediates Neuroprotection by 17β-Estradiol

(2010) Joachim G Elzer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of mitochondrial dysfunction on the immunological properties of microglia

(2010) Annette I Ferger et al.   Journal of Neuroinflammation

The Neurotoxic Effects of Estrogen on Ischemic Stroke in Older Female Rats Is Associated with Age-Dependent Loss of Insulin-Like Growth Factor-1

(2010) A. Selvamani et al.   JOURNAL OF NEUROSCIENCE

Interferon-γ Decreases Chondroitin Sulfate Proteoglycan Expression and Enhances Hindlimb Function after Spinal Cord Injury in Mice

(2010) Takayuki Fujiyoshi et al.   JOURNAL OF NEUROTRAUMA

Mesenchymal stem cell transplantation modulates neuroinflammation in focal cerebral ischemia: Contribution of fractalkine and IL-5

(2010) Abdullah Md. Sheikh et al.   NEUROBIOLOGY OF DISEASE

Estrogen or Estrogen Receptor Agonist Inhibits Lipopolysaccharide Induced Microglial Activation and Death

(2010) Joshua A. Smith et al.   NEUROCHEMICAL RESEARCH

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Effects of human marrow stromal cells on activation of microglial cells and production of inflammatory factors induced by lipopolysaccharide

(2009) Chang Zhou et al.   BRAIN RESEARCH

Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats

(2009) Shuying Lin et al.   EXPERIMENTAL NEUROLOGY

Role of glutamate and its receptors and insulin-like growth factors in hypoxia induced periventricular white matter injury

(2009) Viswanathan Sivakumar et al.   GLIA

Changes in Experimental Stroke Outcome across the Life Span

(2009) Fudong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sex Differences in Minocycline-Induced Neuroprotection after Experimental Stroke

(2009) Jun Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oestradiol and Insulin-Like Growth Factor-1 Reduce Cell Loss after Global Ischaemia in Middle-Aged Female Rats

(2009) M. L. Traub et al.   JOURNAL OF NEUROENDOCRINOLOGY

Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis

(2009) Eric Blasko et al.   JOURNAL OF NEUROIMMUNOLOGY

Estrogen Attenuates Ischemic Oxidative Damage via an Estrogen Receptor  -Mediated Inhibition of NADPH Oxidase Activation

(2009) Q.-G. Zhang et al.   JOURNAL OF NEUROSCIENCE

Temporal and Regional Changes in IGF-1/IGF-1R Signaling in the Mouse Brain after Traumatic Brain Injury

(2009) Sindhu Kizhakke Madathil et al.   JOURNAL OF NEUROTRAUMA

Delayed peripheral administration of the N-terminal tripeptide of IGF-1 (GPE) reduces brain damage following microsphere induced embolic damage in young adult and aged rats

(2009) Shlomo Shapira et al.   NEUROSCIENCE LETTERS

Expression of OX40 ligand in microglia activated by IFN-γ sustains a protective CD4+ T-cell response in vitro

(2008) Yanyan Wang et al.   CELLULAR IMMUNOLOGY

PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease

(2008) Arnulfo Quesada et al.   Developmental Neurobiology

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke

(2008) Pär Thored et al.   GLIA

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats

(2008) Danielle K. Lewis et al.   JOURNAL OF NEUROIMMUNOLOGY

Brain microglia express steroid-converting enzymes in the mouse

(2008) Andres Gottfried-Blackmore et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats

(2008) Amutha Selvamani et al.   NEUROBIOLOGY OF AGING