GABAAreceptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

Assessment of Homology Templates and an Anesthetic Binding Site within the γ-Aminobutyric Acid Receptor

(2013) Edward J. Bertaccini et al.   ANESTHESIOLOGY

Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor

(2013) David C. Chiara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

(2013) Ludovic Sauguet et al.   Nature Communications

Teaching an Old GABA Receptor New Tricks

(2012) James R. Trudell et al.   ANESTHESIA AND ANALGESIA

Mapping General Anesthetic Binding Site(s) in Human α1β3 γ-Aminobutyric Acid Type A Receptors with [3H]TDBzl-Etomidate, a Photoreactive Etomidate Analogue

(2012) David C. Chiara et al.   BIOCHEMISTRY

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism for the Dual Alcohol Modulation of Cys-loop Receptors

(2012) Samuel Murail et al.   PLoS Computational Biology

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

(2010) Guo-Dong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling Anesthetic Binding Sites within the Glycine Alpha One Receptor Based on Prokaryotic Ion Channel Templates: The Problem with TM4

(2010) Edward J. Bertaccini et al.   Journal of Chemical Information and Modeling

A Transmembrane Amino Acid in the GABAA Receptor  2 Subunit Critical for the Actions of Alcohols and Anesthetics

(2010) M. L. McCracken et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel

(2009) Yun Weng et al.   ANESTHESIA AND ANALGESIA

GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor  1M1- 2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site

(2009) M. Bali et al.   JOURNAL OF NEUROSCIENCE

Molecular Modeling and Mutagenesis Reveals a Tetradentate Binding Site for Zn2+in GABAAαβ Receptors and Provides a Structural Basis for the Modulating Effect of the γ Subunit

(2008) James R. Trudell et al.   Journal of Chemical Information and Modeling

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

GABAA receptors and alcohol

(2008) Ingrid A. Lobo et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR