Article
Biochemistry & Molecular Biology
Maximiliano Elgueta-Reyes, Victoria B. Velasquez, Pedro Espinosa, Raul Riquelme, Tatiana Dib, Nicole K. Sanguinetti, Angelica P. Escobar, Jonathan Martinez-Pinto, Georgina M. Renard, Ramon Sotomayor-Zarate
Summary: Early life exposure to sex hormones has long-lasting effects on brain areas involved in regulating locomotor and motivation behaviors. This study demonstrates that neonatal exposure to sex hormones alters the brain dopamine system and affects behavioral and neurochemical responses to amphetamine and methylphenidate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aske L. Ejdrup, Joel Wellbourne-Wood, Jakob K. Dreyer, Nina Guldhammer, Matthew D. Lycas, Ulrik Gether, Benjamin J. Hall, Gunnar Sorensen
Summary: A fundamental concept in neuroscience is the transmission of information between neurons via neurotransmitters, modulators, and peptides. The gold standard for measuring neurochemicals in awake animals has been microdialysis (MD), but genetically encoded fluorescence-based biosensors and in vivo optical techniques have introduced technologically distinct means of measuring neurotransmission. Comparing MD and fiber photometry (FP), the study found that although there were temporal differences, the readouts of extracellular dopamine (DA) correlated well within mice. Down-sampling of FP data showed temporal correlation to MD, with less variance observed using FP. The study also discovered periodic low levels of DA fluctuations and rapid predrug DA dynamics measured with FP that correlated to the subsequent pharmacodynamics of amphetamine as measured with MD and FP.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Kim
Summary: This study demonstrates that simultaneous exposure to different metals can impact key enzymes involved in dopaminergic and serotonergic neurotransmission processes, leading to disruptions in dopamine and serotonin homeostasis and consequently a range of detrimental neurobehavioral effects.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Neurosciences
Klara Danielsson, Oona Lagstrom, Mia Ericson, Bo Soderpalm, Louise Adermark
Summary: The study suggests that repeated amphetamine exposure leads to selective effects on dopamine signaling in striatal subregions, explaining why tolerance develops towards the drug's rewarding effects but not its psychosis inducing properties.
Article
Neurosciences
Erika Lucente, Bo Soederpalm, Mia Ericson, Louise Adermark
Summary: This study aimed to investigate the acute and sustained effects of nicotine on the female rat brain, focusing on changes in dopamine neurotransmission and synaptic plasticity. The findings showed that nicotine can decrease excitatory neurotransmission, enhance synaptic long-term depression, and induce behavioral sensitization and increased neurophysiological responsiveness. These effects may contribute to the establishment of persistent nicotine taking habits.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Daniel J. Liput, Henry L. Puhl, Ao Dong, Kaikai He, Yulong Li, David M. Lovinger
Summary: This study investigates the mechanisms of eCB mobilization in the DLS, and finds that brief bouts of synaptic stimulation induce long lasting eCB transients, mainly generated by 2-AG mobilization. The efficient mobilization of 2-AG requires coactivation of multiple receptors and is inhibited by dopamine D2 receptors.
Article
Neurosciences
Angelica P. Escobar, Jonathan Martinez-Pinto, Francisco Silva-Olivares, Ramon Sotomayor-Zarate, Pablo R. Moya
Summary: EAAT3 overexpression impacts dopamine transmission, making dopamine neurons more sensitive to the effects of amphetamine and leading to an imbalance between the direct and indirect striatal pathways that favors the performance of repetitive behaviors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biology
Lise M. Sjogaard-Frich, Andreas Prestel, Emilie S. Pedersen, Marc Severin, Kristian Kolby Kristensen, Johan G. Olsen, Birthe B. Kragelund, Stine Falsig Pedersen
Summary: Through various biophysical techniques, this study reveals the complex interaction mechanism between CaM and NHE1, identifying multiple states and structures of the NHE1:CaM complex that can be modulated by stoichiometries, calcium concentrations, and phosphorylation. Experimental results suggest that CaM may enhance NHE1 regulation and indicate that this structural diversity is relevant to other CaM complexes as well.
Article
Pharmacology & Pharmacy
Wenli Liao, Zhiwei Rao, Lingling Wu, Yong Chen, Cairong Li
Summary: The study demonstrated that CAR has significant protective effects against DOX-induced cardiotoxicity in rats by suppressing oxidative stress, inflammation, and apoptosis, at least in part, through regulation of Akt/GSK-3 beta and Sirt1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Biological
Yongzhao Fan, Yuhan Wang, Wenliang Ji, Kun Liu, Hao Wu
Summary: The study showed that pre-ischemic voluntary wheel running for 1 or 4 weeks can significantly increase the basal dopamine level, attenuate the increase of striatal dopamine induced by cerebral ischemia, and improve neurocognitive function in ischemia rats.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Neurosciences
Sergio Garcia Guerra, Andrea Spadoni, Jennifer Mitchell, Irina A. Strigo
Summary: This study investigates the interaction between opioidergic and dopaminergic processing in the human brain during pain-related experiences using radioligand studies. The results show that there is a functional overlap between opioid and dopamine activations in most regions, but also some unique activation areas.
Article
Neurosciences
Lilian R. F. Faro, Lorenzo Justo, Raquel Gomez, Rafael Duran
Summary: Isatin can increase dopamine release by raising glutamate levels and potentially activating NMDA receptors and nitric oxide production.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Li-Jin Chen, Jeng-Rung Chen, Guo-Fang Tseng
Summary: Hydrocephalus alters neurotransmission pathways in the striatum, disrupting the balance between the basal ganglia circuits, which may contribute to motor impairments in hydrocephalus.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Medicine, Research & Experimental
Laween Uthman, Xiaoling Li, Antonius Baartscheer, Cees A. Schumacher, Patricia Baumgart, Jeroen Hermanides, Benedikt Preckel, Markus W. Hollmann, Ruben Coronel, Coert J. Zuurbier, Nina C. Weber
Summary: Inflammation leading to oxidative stress in endothelial cells is linked to heart failure development. The study suggests that TNF-alpha can activate NHE to raise [Na+](c), triggering ROS production, and EMPA can reduce inflammation-induced ROS by inhibiting NHE activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Yanli Dong, Yiwei Gao, Alina Ilie, DuSik Kim, Annie Boucher, Bin Li, Xuejun C. Zhang, John Orlowski, Yan Zhao
Summary: NHE1 and CHP1 are proteins that regulate intracellular pH and volume homeostasis. The structures of the human NHE1-CHP1 complex provide insight into how CHP1 influences the pH-sensitivity of NHE1 and interactions with NHE1 inhibitors.
NATURE COMMUNICATIONS
(2021)
Article
Toxicology
Muhammad M. Hossain, Ganeshraj Sivaram, Jason R. Richardson
TOXICOLOGICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Dahea You, Hye Min Shin, Fatimah Mosaad, Jason R. Richardson, Lauren M. Aleksunes
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Review
Pharmacology & Pharmacy
Aseel Eid, Isha Mhatre, Jason R. Richardson
PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Pharmacology & Pharmacy
Xia Wen, Angela A. Baker, Curtis D. Klaassen, J. Christopher Corton, Jason R. Richardson, Lauren M. Aleksunes
Article
Neurosciences
Lijie Feng, Madhuvika Murugan, Dale B. Bosco, Yong Liu, Jiyun Peng, Gregory A. Worrell, Hai-Long Wang, Lauren E. Ta, Jason R. Richardson, Yuxian Shen, Long-Jun Wu
Article
Neurosciences
Jiyun Peng, Yong Liu, Anthony D. Umpierre, Manling Xie, Dai-Shi Tian, Jason R. Richardson, Long-Jun Wu
Article
Biochemistry & Molecular Biology
Matthew L. Neal, Sheila M. Fleming, Kevin M. Budge, Alexa M. Boyle, Chunki Kim, Gelareh Alam, Eric E. Beier, Long-Jun Wu, Jason R. Richardson
Article
Toxicology
Muhammad M. Hossain, Jason R. Richardson
TOXICOLOGICAL SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Dahea You, Jason R. Richardson, Lauren M. Aleksunes
DRUG METABOLISM AND DISPOSITION
(2020)
Article
Neurosciences
Kevin M. Budge, Matthew L. Neal, Jason R. Richardson, Fayez F. Safadi
MOLECULAR NEUROBIOLOGY
(2020)
Article
Immunology
Wenning Wu, Yujiao Li, Yujia Wei, Dale B. Bosco, Manling Xie, Ming-Gao Zhao, Jason R. Richardson, Long-Jun Wu
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Biochemistry & Molecular Biology
Valentina Dal Pozzo, Beth Crowell, Nicholas Briski, David P. Crockett, Gabriella D'Arcangelo
Editorial Material
Chemistry, Medicinal
Jason Richardson, Yinsheng Wang
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Neurosciences
Melissa K. Edler, Cooper T. Johnson, Hashim S. Ahmed, Jason R. Richardson
Summary: The study found that CD36 expression in the mouse brain varies significantly by age, region, and sex, potentially contributing to A β deposition and neuroinflammation in Alzheimer's disease.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Kevin Budge, Matthew Neal, Jason Richardson, Fayez Safadi
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)