Article
Medicine, General & Internal
Julien Coelho, Regis Lopez, Jacques Taillard, Emmanuel D'Incau, Guillaume Fond, Pierre Philip, Jean-Arthur Micoulaud-Franchi
Summary: The present study analyzed the validity of the French version of the Barcelona Sleepiness Index (BSI) in screening for excessive daytime sleepiness (EDS). The study found a strong correlation between BSI scores and Epworth Sleepiness Scale (ESS) scores, and demonstrated that the BSI can effectively predict EDS. Additionally, BSI scores were associated with sleep deprivation and social jetlag.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jeanne F. Duffy, Wei Wang, Joseph M. Ronda, Charles A. Czeisler
Summary: Aging is associated with changes in sleep, and improving sleep can have important consequences for the health and quality of life of older adults. Melatonin, especially at higher doses, may be a viable option for sleep aid in older adults, as it can increase sleep efficiency during both the day and night.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Neurosciences
Zebin Wang, Shan Zeng, Yan Jing, Wenjuan Mao, Hongyan Li
Summary: Sarm1 plays a role in regulating circadian rhythm disturbances and AD progression. Sarm1 deficiency improves cognitive disorders, reduces Aβ plaque deposition, inhibits astrocyte activation, improves circadian rhythm, and alters clock molecule expression. These findings suggest that Sarm1 could be a therapeutic target to improve circadian rhythm and impede AD progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Antoine Langeard, Amira Zouabi, Tristan Martin, Gaelle Quarck, Antoine Gauthier
Summary: The study aimed to investigate whether postural control in older adults followed a circadian rhythm and to examine the circadian variations in balance performances. The results showed that older adults presented a circadian rhythm of balance, especially in more challenging conditions, while vertical perception did not significantly follow a circadian rhythm.
Review
Cell Biology
Md Farhad Hossain, Ni Wang, Ruijun Chen, Siwen Li, Jaydeep Roy, Md Giash Uddin, Zhong Li, Lee Wei Lim, You-Qiang Song
Summary: Melatonin plays crucial roles in Alzheimer's disease by promoting autophagy, improving sleep quality, and counteracting oxidative stress. The therapeutic potential of melatonin in AD may involve its multifunctional properties.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Charley Ximing Jin, Kate Sutherland, Thorarinn Gislason, Elin Helga Thorarinsdottir, Lia Bittencourt, Sergio Tufik, Bhajan Singh, Nigel McArdle, Peter Cistulli, Yu Sun Bin
Summary: Social jetlag is associated with daytime sleepiness in patients with obstructive sleep apnea (OSA). The study found that social jetlag of over 2 hours was significantly associated with higher levels of daytime sleepiness. Improving sleep timing could be a simple therapeutic target for reducing the impact of OSA.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Viktoria Nemeth, Szabina Horvath, Agnes Kinyo, Rolland Gyulai, Zsuzsanna Lengyel
Summary: In this study, perturbations in clock gene transcripts were observed in both uninvolved and lesional psoriatic areas, suggesting their potential as therapeutic targets and the development of chronotherapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Huiyi Wu, Lei Huang, Shushan Zhang, Yang Zhang, Yajia Lan
Summary: The study aimed to evaluate the associations between daytime napping, biological aging measures, and cognition, and examine whether the effects on cognition were mediated by a more advanced state of aging. It was found that non-nappers showed a more advanced state of aging and faster cognitive decline compared to moderate nappers. The results suggest that moderate napping could promote healthy aging and reduce cognitive decline in middle-aged and older Chinese adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Neurosciences
Jie Zhang, Shang Gao, Wei Liu
Summary: This study used bioinformatics to reveal the relationship between circadian rhythm and Alzheimer's disease at the genetic level. The results showed a strong association between circadian rhythm and Alzheimer's disease, as well as identified important genes and signaling pathways related to inflammation.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Clinical Neurology
Jun Song Isaac Tan, Ling Jie Cheng, Ee Yuee Chan, Ying Lau, Siew Tiang Lau
Summary: The study found that light therapy has a certain effect on sleep disturbances in older adults with dementia, significantly reducing nighttime awakenings and improving sleep quality and relative amplitude. The results may vary in different regions. However, the current level of evidence is low, and more large-scale trials are needed to draw more definitive conclusions.
Review
Cell Biology
Deepak Kumar, Ashish Sharma, Rajeev Taliyan, Maiko T. Urmera, Oscar Herrera-Calderon, Thomas Heinbockel, Shafiqur Rahman, Rohit Goyal
Summary: Circadian rhythms are regulated by the master clock in the suprachiasmatic nucleus, entrained to the light-dark cycle by the retino-hypothalamic tract. Disruption of circadian rhythms due to unhealthy lifestyle and chronic photic disturbances has been linked to Alzheimer's disease. The presence of endocannabinoids in CRd-induced Alzheimer's disease has been identified as a potential target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Neurosciences
Fabrics Bertile, Marine Plumel, Pauline Maes, Aurelie Hirschler, Etienne Challet
Summary: The study identified day-night variations in the cerebellar proteome of mice fed during daytime or nighttime, showing changes in proteins related to heat-shock proteins, enzymes, and neuronal activity in daytime food-restricted mice. Additionally, a significant feeding x time-of-day interaction was found for changes in the intensity of 20 spots.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Michal Dudek, Joe Swift, Qing-Jun Meng
Summary: The extracellular matrix (ECM) provides crucial signals to instruct cellular behavior and is regulated by circadian clocks. Aging and modern society disrupt circadian rhythms, which may contribute to ECM imbalance. Understanding the daily dynamics of ECM and its changes with age is important for tissue health, disease prevention, and treatment improvement.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Immunology
Huiling He, Yingxia Yang, Lingxing Wang, Zeming Guo, Lichao Ye, Wanjiong Ou-Yang, Meili Yang
Summary: This study identified circadian rhythm disruption (CRD)-based cell subtypes in the Alzheimer's disease (AD) microenvironment at the single-cell level and constructed a robust CRD signature for accurate prediction of AD onset. The findings suggest a strong association between CRD and the immunological and biological features of AD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Vincenzo Muto, Ekaterina Koshmanova, Pouya Ghaemmaghami, Mathieu Jaspar, Christelle Meyer, Mahmoud Elansary, Maxime Van Egroo, Daphne Chylinski, Christian Berthomier, Marie Brandewinder, Charlotte Mouraux, Christina Schmidt, Gregory Hammad, Wouter Coppieters, Naima Ahariz, Christian Degueldre, Andre Luxen, Eric Salmon, Christophe Phillips, Simon N. Archer, Loic Yengo, Enda Byrne, Fabienne Collette, Michel Georges, Derk-Jan Dijk, Pierre Maquet, Peter M. Visscher, Gilles Vandewalle
Summary: The study found that genetic risk scores for Alzheimer's disease are associated with sleep characteristics in young adults, suggesting a potential link between sleep and AD risk.
Article
Geriatrics & Gerontology
Yoni C. P. Sep, Anna E. Leeuwis, Lieza G. Exalto, Jooske M. Boomsma, Niels D. Prins, Jurre H. Verwer, Philip Scheltens, Wiesje M. van der Flier, Geert Jan Biessels, TRACE-VCI study group Behalf TRACE VCI Study Grp
Summary: This study examines the association between neuropsychiatric symptoms (NPS) and clinical outcomes in memory clinic patients with possible Vascular Cognitive Impairment (VCI). The findings reveal that NPS are common in this patient group and are associated with institutionalization, mortality, and cognitive deterioration. The association between NPS and clinical outcomes varies depending on the severity of cognitive impairment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Agnetha D. Fruijtier, Jetske van der Schaar, Ingrid S. van Maurik, Marissa D. Zwan, Philip Scheltens, Femke Bouwman, Yolande A. L. Pijnenburg, Bart N. M. van Berckel, Jarith Ebenau, Wiesje M. van der Flier, Ellen M. A. Smets, Leonie N. C. Visser
Summary: This study investigated the impact of six communication strategies on amyloid disclosure in mild cognitive impairment (MCI) patients. It found that risk communication best practices resulted in the highest information recall, while recall in emotional support was better than the basic and elaborate information strategies. Risk communication best practices also led to the highest uncertainty, while teach-back and emotional support contributed to the highest evaluations of the physician and information. Overall, risk communication best practices, attending to emotions, and teach-back techniques enhance information recall and contribute to positive care evaluations for amyloid-PET results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Health Care Sciences & Services
Mark A. Dubbelman, Caroline B. Terwee, Merike Verrijp, Leonie N. C. Visser, Philip Scheltens, Sietske A. M. Sikkes
Summary: The study established clinically meaningful scoring categories for the Amsterdam IADL questionnaire, providing guidance for clinicians to interpret scores and communicate with patients and caregivers effectively.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Clinical Neurology
Marthe E. Ford, Gert J. Geurtsen, Erny Groet, Radha D. Rambaran Mishre, Coen A. M. Van Bennekom, Eus J. W. Van Someren
Summary: This study demonstrates that blended CBT is an effective treatment for insomnia in individuals with acquired brain injury, regardless of cognitive and psychiatric symptoms. Online treatment has significant advantages in terms of availability and cost, and can contribute to the successful implementation of insomnia treatment for individuals with acquired brain injuries.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Lara Rosler, Glenn van Der Lande, Jeanne Leerssen, Roy Cox, Jennifer R. Ramautar, Eus J. W. van Someren
Summary: Actigraphy has been widely used as a cost-effective and easy-to-use tool for ambulatory sleep recording. However, there is little evidence to support the use of actigraphy in diagnosing or treating insomnia. This study found that actigraphy sleep estimates and circadian patterns failed to differentiate patients with insomnia from controls in the home environment, suggesting a need for alternative indicators of sleep quality in insomnia research.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Joy Perrier, Jessica Bruijel, Mikael Naveau, Jennifer Ramautar, Nicolas Delcroix, Joris Coppens, Oti Lakbila-Kamal, Diederick Stoffers, Nicolas Bessot, Eus J. W. Van Someren
Summary: Insomnia is associated with poor executive functioning. Functional connectivity differences were found in insomnia patients during the orienting and executive control processes compared to good sleepers. Insomniacs displayed weaker cortical connectivity during orienting and stronger connectivity during executive control. Reaction time was inversely correlated with connectivity differences.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Medicine, Research & Experimental
J. E. Reesen, T. van der Zweerde, N. M. Batelaan, E. Fris, A. W. Hoogendoorn, S. Ikelaar, O. Lakbila-Kamal, J. Lancee, J. Leerssen, H. J. F. van Marle, F. van Nassau, P. van Oppen, A. van Straten, S. van Trigt, S. J. van der Wal, E. J. W. van Someren
Summary: This transdiagnostic randomized control trial evaluates the effects of guided internet-delivered cognitive behavioral therapy for insomnia on sleep quality and emotional distress. The study aims to improve sleep, reduce emotional symptoms, and enhance the effectiveness of regular treatment. The trial includes 576 participants and uses a randomized control design with a primary outcome measure of insomnia severity.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Neurosciences
Frans Schalkwijk, Eus J. W. Van Someren, Nelleke J. Nicolai, Julia L. Uijttewaal, Rick Wassing
Summary: A new line of insomnia research explores the developmental trajectories from early life stress to insomnia in adulthood. The findings indicate that adverse childhood experiences (ACE's) may lead to maladaptive coping styles and chronic hyperarousal or insomnia. The study also suggests that trauma and emotional processing should be considered in the treatment of insomnia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Thiprawee Chattrattrai, Ghizlane Aarab, Tessa F. Blanken, Gabriel N. Pires, Alberto Herrero Babiloni, Cibele Dal Fabbro, Eus van Someren, Gilles Lavigne, Milton Maluly, Monica L. Andersen, Sergio Tufik, Frank Lobbezoo
Summary: This study investigated the associations of self-reported sleep bruxism with other sleep disorders and demographic, psychological, and lifestyle factors in the adult general population. The results showed that self-reported sleep bruxism was only significantly associated with sex, anxiety, and depression, while polysomnographically confirmed sleep bruxism was not associated with any of the included factors.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Roy Cox, Lara Rosler, Frederik D. Weber, Tessa F. Blanken, Rick Wassing, Jennifer R. Ramautar, Eus J. W. Van Someren
Summary: The nature and degree of objective sleep impairments in insomnia disorder are still unclear. Changes in sleep architecture on the first compared with subsequent nights in the laboratory further complicate this issue. There is mixed evidence regarding differential first-night effects in people with insomnia disorder and controls. This study aims to characterize insomnia- and night-related differences in sleep architecture. People with insomnia consistently had poorer sleep than controls on multiple variables during both nights. Although short sleep was more likely during the first night and in insomnia, a significant number of patients with insomnia no longer met this criterion on the second night, highlighting the importance of considering short-sleeping insomnia as a subtype.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Heloise Rach, Eve Reynaud, Ulker Kilic-Huck, Elisabeth Ruppert, Henri Comtet, Virginie Roy de Belleplaine, Fanny Fuchs, Eus J. W. Van Someren, Pierre A. A. Geoffroy, Patrice Bourgin
Summary: The absence of biomarkers makes it difficult to diagnose idiopathic hypersomnia and distinguish it from other central hypersomnia subtypes. By studying the retinal melanopsin-based pupil response, it was found that both idiopathic hypersomnia and narcolepsy type 1 patients had a reduced pupil response compared to controls. Additionally, basal pupil size was found to be a good discriminator between idiopathic hypersomnia and narcolepsy type 1.
JOURNAL OF SLEEP RESEARCH
(2023)
Editorial Material
Neurosciences
Anita Luthi, Paul Franken, Stephany Fulda, Francesca Siclari, Eus J. W. Van Someren
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Frank Verkaik, Marthe E. E. Ford, Gert J. J. Geurtsen, Eus J. W. Van Someren
Summary: This study evaluated the role of sleep-related beliefs and behaviors in insomnia after acquired brain injury. The findings showed a significant correlation between these factors and insomnia severity. However, it was found that not all sleep-related beliefs and behaviors were inappropriate and maladaptive for the acquired brain injury population, but could reflect adequate observations and efforts in coping with the consequences of the brain damage.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychology, Clinical
Desana Kocevska, Isabel K. K. Schuurmans, Charlotte A. M. Cecil, Pauline W. W. Jansen, Eus J. W. van Someren, Annemarie I. I. Luik
Summary: Early life stress is strongly associated with poor sleep, and this association may start during prenatal development. This study investigates the longitudinal associations between prenatal psychosocial stress and childhood sleep, and examines whether prenatal stress interacts with genetic factors for poor sleep. The results show that prenatal stress is consistently related to sleep problems in children, and this association is exacerbated by genetic vulnerability for insomnia.
RESEARCH ON CHILD AND ADOLESCENT PSYCHOPATHOLOGY
(2023)
Article
Clinical Neurology
Tom Bresser, Jeanne Leerssen, Stefanie Hoelsken, Inge Groote, Jessica C. Foster-Dingley, Martijn P. van den Heuvel, Eus J. W. Van Someren
Summary: Insomnia poses a high risk for depression, and the effects of cognitive behavioural therapy on insomnia-related brain mechanisms are unclear. This longitudinal study suggests that individual differences in brain white matter microstructure at baseline may predict improvements in depressive symptoms, and interventions can affect white matter microstructure.
BRAIN COMMUNICATIONS
(2023)