Article
Gastroenterology & Hepatology
Alexandra Shingina, Nizar Mukhtar, Jamile Wakim-Fleming, Saleh Alqahtani, Robert J. Wong, Berkeley N. Limketkai, Anne M. Larson, Lafaine Grant
Summary: Acute liver failure (ALF) is a rare, potentially reversible condition that causes severe liver damage and rapid clinical deterioration in patients without preexisting liver disease. Due to limited studies, guidelines provided by the American College of Gastroenterology serve as the official practice recommendations for the identification, treatment, and management of ALF. The guidelines were developed through a process of reviewing scientific evidence and using expert opinions when robust evidence was lacking. Individualized care should be applied in specific clinical scenarios due to the varied clinical presentations of ALF.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen, Xiaoxiao Shi, Di Chen, Kai Wang, Kang Jiang, Dan Xu, Ming Cheng, Juan Li, Wenting Li, Weijun Xu, Lin Zhou, Mingzuo Jiang, Bing Xu
Summary: Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF). DDX3X plays a role in pro-survival stress granule (SG) assembly, but its role in DILI is unknown. This study revealed that DDX3X expression is decreased in DILI patients and DDX3X deficient mice. DDX3X deficiency aggravated liver injury in multiple DILI models by enhancing oxidative stress, hepatocyte death, and inflammatory responses.
CELL DEATH & DISEASE
(2023)
Article
Pharmacology & Pharmacy
Zhongyan Du, Zhimei Ma, Shanglei Lai, Qinchao Ding, Ziyi Hu, Wenwen Yang, Qianyu Qian, Linwensi Zhu, Xiaobing Dou, Songtao Li
Summary: This study aimed to evaluate the protective effects of Atractylenolide I (AO-I) against acetaminophen (APAP)-induced acute liver injury. The results showed that AO-I treatment significantly reversed APAP-induced liver injury, alleviated oxidative stress and inflammation, and inhibited the activation of TLR4/MAPKs/NF-kappa B pathways. AO-I is a potential therapeutic compound for APAP-induced hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xin Hou, Qi Liu, Yimin Gao, Liang Yong, Huiyuan Xie, Wenting Li, Yuping Zhou, Jun Liu, Lijie Feng, Long Xu, Yuxian Shen, Hua Wang
Summary: The levels of mesencephalic astrocyte-derived neurotrophic factor (MANF) were found to be elevated in drug-induced liver injury, and MANF plays an important role in immune regulation and liver repair. MANF may enhance IL-10 expression and phagocytosis in macrophages via the p38 MAPK pathway, promoting the phenotype conversion of inflammatory macrophages to pro-restorative macrophages.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Pengfei Xu, Yue Xi, Pengcheng Wang, Zigmund Luka, Meishu Xu, Hung-Chun Tung, Jingyuan Wang, Songrong Ren, Dechun Feng, Bin Gao, Aatur D. Singhi, Satdarshan P. Monga, John D. York, Xiaochao Ma, Zhiying Huang, Wen Xie
Summary: This study reveals the important role of PAPSS2 in APAP-induced acute liver failure. PAPSS2 protects liver cells from damage by increasing hepatic antioxidative capacity through the activation of the p53-p2-Nrf2 axis.
Article
Pharmacology & Pharmacy
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Summary: This study demonstrates the beneficial effects of exogenous phosphatidic acid in acetaminophen toxicity by activating IL-6 signaling. However, despite the importance of PA in liver repair, exogenous PA did not alter regeneration.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pediatrics
Yu-ming Guo, Fei-lin Ge, Hai-bo Song, Peng Xiong, Jing Jing, Ming Niu, Xu Zhao, Zhao-fang Bai, Jia-bo Wang, Xiao-he Xiao
Summary: Children, especially infants, are sensitive to liver-related adverse drug reactions caused by several specific drug categories.
JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Wenjing Dong, Erqun Song, Yang Song
Summary: The study found that co-treatment of LPS/D-GalN exhibited genotoxic effects on liver and brain cells in mice, but not on sperm and bone marrow cells. This indicates the potential genotoxicity of LPS/D-GalN administered together, suggesting it as an in vivo experimental model for genotoxic studies.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
R. Todd Stravitz, Robert J. Fontana, Caitlyn Meinzer, Valerie Durkalski-Mauldin, A. James Hanje, Jody Olson, David Koch, Bilal Hamid, Michael L. Schilsky, Brendan McGuire, Daniel Ganger, Iris Liou, Constantine J. Karvellas, Jody A. Rule, Ton Lisman, Kristin Clasen, Adrian Reuben, Michael Cripps, William M. Lee
Summary: In patients with acute liver injury or failure (ALI/ALF), abnormal ROTEM parameters are common and proportional to disease severity. Whether the increased bleeding risk associated with abnormal ROTEM indicates hemostatic failure or is a proxy for disease severity requires additional study.
Article
Biochemistry & Molecular Biology
Yuguo Yi, Weigao Zhang, Liang Tao, Qianchao Shao, Qian Xu, Yuxin Chen, Haibing Zhang, Jianfa Zhang, Dan Weng
Summary: This study investigated the role of RIP1 kinase in APAP-induced acute liver injury through genetic or pharmacological inhibition, providing evidence that RIP1 kinase activity plays an important role in the pathogenesis of APAP-induced liver injury. The results demonstrated that RIP1 kinase inactivation significantly attenuated APAP-induced liver injury and mortality, and that Nec-1, a RIP1 kinase inhibitor formulated with PEG400, could efficiently alleviate hepatotoxicity induced by APAP.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Christina Scharf, Uwe Liebchen, Michael Paal, Andrea Becker-Pennrich, Michael Irlbeck, Michael Zoller, Ines Schroeder
Summary: This study compared the efficacy of CytoSorb and ADVOS in treating ALD, finding that both treatments led to a significant and comparable decrease in total bilirubin levels, with the advantage of CytoSorb's easy usability compared to other procedures.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Xinyu Zeng, Jiajie Jiang, Simiao Liu, Qichao Hu, Sihan Hu, Jinhao Zeng, Xiao Ma, Xiaomei Zhang
Summary: Geniposide exhibits dual pharmacological activity in liver injury, exerting potent hepatoprotective effects within a specific dose and time range, but also causing liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji, Qiang You
Summary: The study demonstrated that CD36 deficiency ameliorated APAP-induced acute liver injury and inflammatory responses by decreasing JNK activation. CD36 might serve as a new target to reduce acute liver injury.
MOLECULAR MEDICINE
(2021)
Article
Family Studies
Kathleen A. Noorbakhsh, Rachel P. Berger, Sriram Ramgopal
Summary: This study evaluated the validity of converting ICD-9-CM diagnosis codes to the 10th revision for identifying child maltreatment. The results showed that the current conversion methods are not consistently reliable, highlighting the need for independent construction and validation of ICD-10-based definitions of child maltreatment.
CHILD ABUSE & NEGLECT
(2022)
Article
Gastroenterology & Hepatology
Robert J. Fontana, Einar S. Bjornsson, Rajender Reddy, Raul J. Andrade
Summary: Idiosyncratic drug-induced liver injury (DILI) is a rare but significant cause of liver disease. Newly identified causes of DILI include COVID vaccines, turmeric, green tea extract, and immune checkpoint inhibitors. DILI is diagnosed through exclusion, requiring evaluation for more common causes and a temporal association with the suspected drug. Advances in DILI causality assessment and drug-specific HLA associations have improved diagnosis and prognosis. LiverTox provides important information on the hepatotoxicity profile of medications and supplements.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Vincent Lo Re, Craig W. Newcomb, Dena M. Carbonari, Jason A. Roy, Keri N. Althoff, Mari M. Kitahata, K. Rajender Reddy, Joseph K. Lim, Michael J. Silverberg, Angel M. Mayor, Michael A. Horberg, Edward R. Cachay, Gregory D. Kirk, Mark Hull, John Gill, Timothy R. Sterling, Jay R. Kostman, Marion G. Peters, Richard D. Moore, Marina B. Klein, H. Nina Kim
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2019)
Article
Public, Environmental & Occupational Health
M. Elle Saine, Dena M. Carbonari, Craig W. Newcomb, Arlene M. Gallagher, Betina T. Blak, Jason A. Roy, Jennifer Wood, Serena Cardillo, Sean Hennessy, Brian L. Strom, Vincent Lo Re
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2019)
Article
Oncology
Jessie Torgersen, Tamar H. Taddei, Lesley S. Park, Dena M. Carbonari, Michael J. Kallan, Kisha Mitchell Richards, Xuchen Zhang, Darshana Jhala, Norbert Br Au, Robert Homer, Kathryn D'Addeo, Rajni Mehta, Melissa Skanderson, Farah Kidwai-Khan, Amy C. Justice, Vincent Lo Re
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Jessie Torgersen, Michael J. Kallan, Dena M. Carbonari, Lesley S. Park, Rajni L. Mehta, Kathryn D'Addeo, Janet P. Tate, Joseph K. Lim, Matthew Bidwell Goetz, Maria C. Rodriguez-Barradas, Cynthia L. Gibert, Norbert Brau, Sheldon T. Brown, Jason A. Roy, Tamar H. Taddei, Amy C. Justice, Vincent Lo Re
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Immunology
Jessie Torgersen, Michael J. Kallan, Dena M. Carbonari, Lesley S. Park, Rajni L. Mehta, Kathryn D'Addeo, Janet P. Tate, Joseph K. Lim, Matthew Bidwell Goetz, Maria C. Rodriguez-Barradas, Norbert Brau, Sheldon T. Brown, Tamar H. Taddei, Amy C. Justice, Vincent Lo Re
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2020)
Article
Gastroenterology & Hepatology
H. Nina Kim, Craig W. Newcomb, Dena M. Carbonari, Jason A. Roy, Jessie Torgersen, Keri N. Althoff, Mari M. Kitahata, K. Rajender Reddy, Joseph K. Lim, Michael J. Silverberg, Angel M. Mayor, Michael A. Horberg, Edward R. Cachay, Gregory D. Kirk, Jing Sun, Mark Hull, M. John Gill, Timothy R. Sterling, Jay R. Kostman, Marion G. Peters, Richard D. Moore, Marina B. Klein, Vincent Lo Re
Summary: In individuals coinfected with HIV/HBV, risk factors for HCC include age, HCV coinfection, and heavy alcohol use, while HIV RNA and CD4+ percentage do not directly influence the risk of HCC. Elevated levels of HBV DNA and sustained HBV suppression are crucial in the development of HCC.
Article
Public, Environmental & Occupational Health
Vincent Lo Re, Dena M. Carbonari, Jerry Jacob, William R. Short, Charles E. Leonard, Jennifer G. Lyons, Adee Kennedy, Jolene Damon, Nicole Haug, Esther H. Zhou, David J. Graham, Cheryl N. McMahill-Walraven, Lauren E. Parlett, Vinit Nair, Mano Selvan, Yunping Zhou, Gaia Pocobelli, Judith C. Maro, Michael D. Nguyen
Summary: This study evaluated the positive predictive value of an ICD-10-CM algorithm to identify hospitalizations for serious infections among patients dispensed biologic therapies within a healthcare database. The algorithm had an 80% PPV for confirmed events, indicating its potential use in pharmacoepidemiologic studies.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2021)
Article
Gastroenterology & Hepatology
Jessie Torgersen, Craig W. Newcomb, Dena M. Carbonari, Christopher T. Rentsch, Lesley S. Park, Alyssa Mezochow, Rajni L. Mehta, Lynn Buchwalder, Janet P. Tate, Norbert Brau, Debika Bhattacharya, Joseph K. Lim, Tamar H. Taddei, Amy C. Justice, Vincent Lo Re
Summary: Cases of acute liver injury have been reported among chronic HCV-infected patients receiving protease inhibitor-based direct-acting antiviral therapy, but the risk of severe hepatic dysfunction and decompensation did not differ significantly between patients receiving PI-based or non-PI-based DAAs in either Fibrosis-4 group.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Vincent Lo Re, Sarah K. Dutcher, John G. Connolly, Silvia Perez-Vilar, Dena M. Carbonari, Terese A. DeFor, Djeneba Audrey Djibo, Laura B. Harrington, Laura Hou, Sean Hennessy, Rebecca A. Hubbard, Maria E. Kempner, Jennifer L. Kuntz, Cheryl N. McMahill-Walraven, Jolene Mosley, Pamala A. Pawloski, Andrew B. Petrone, Allyson M. Pishko, Meighan Rogers Driscoll, Claudia A. Steiner, Yunping Zhou, Noelle M. Cocoros
Summary: Based on data from the US public health surveillance system, the risk of venous thromboembolism is significantly higher in COVID-19 patients before and during vaccine availability compared to patients with influenza, whereas the risk of arterial thromboembolism is not significantly different.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Jessica Kim, Craig W. Newcomb, Dena M. Carbonari, Jessie Torgersen, Keri N. Althoff, Mari M. Kitahata, Marina B. Klein, Richard D. Moore, K. Rajender Reddy, Michael J. Silverberg, Angel M. Mayor, Michael A. Horberg, Edward R. Cachay, Joseph K. Lim, M. John Gill, Kara Chew, Timothy R. Sterling, Mark Hull, Eric C. Seaberg, Gregory D. Kirk, Sally B. Coburn, Raynell Lang, Kathleen A. Mcginnis, Kelly A. Gebo, Sonia Napravnik, H. Nina Kim, Vincent Lo Re
Summary: This study conducted a cross-sectional evaluation of the care cascade for HBV among people living with HIV and HBV coinfection in the United States and Canada. The results indicated significant gaps in measurement of HBV DNA and suppression of HBV viremia, emphasizing the importance of regularly evaluating these gaps.
Meeting Abstract
Public, Environmental & Occupational Health
Noelle M. Cocoros, Sarah Dutcher, John Connolly, Silvia Perez-Vilar, Dena Carbonari, Terese Defor, Djeneba Audrey Djibo, Laura Harrington, Laura Hou, Sean Hennessy, Rebecca Hubbard, Maria Kempner, Jennifer Kuntz, Cheryl N. McMahill-Walraven, Jolene Mosley, Pamala Pawloski, Andrew Petrone, Allyson Pishko, Meighan Rogers Driscoll, Claudia Steiner, Yunping Zhou, Vincent Lo Re
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Jessie Torgersen, Craig W. Newcomb, Dena M. Carbonari, Christopher T. Rentsch, Lesley S. Park, Rajni Mehta, Kathryn D'Addeo, Tamar Taddei, Amy C. Justice, Vincent Lo Re
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Alyssa Mezochow, Jessie Torgersen, Craig W. Newcomb, Dena Carbonari, Sean Hennessy, Lesley S. Park, Rajni Mehta, Janet P. Tate, Tamar H. Taddei, Amy C. Justice, Vincent Lo Re
Meeting Abstract
Gastroenterology & Hepatology
Lesley S. Park, Xuchen Zhang, Ilke Nalbantoglu, Farah Kidwai-Khan, Rajni Mehta, Dena Carbonari, Jessie Torgersen, Vincent Lo Re, Amy C. Justice, Tamar H. Taddei
Meeting Abstract
Gastroenterology & Hepatology
Nina Kim, Craig Newcomb, Dena Carbonari, Jason Roy, Keri Althoff, Joseph K. Lim, Edward Cachay, Michael A. Horberg, Michael J. Silverberg, W. Christopher Mathews, Kate Salters, John Gill, Richard D. Moore, Mari M. Kitahata, Marina Klein, Vincent Lo Re