Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 82, Issue 1, Pages 71-80Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0000000000002094
Keywords
hepatitis B; HIV; end-stage liver disease; hepatocellular carcinoma; coinfection
Categories
Funding
- National Institute of Allergy and Infectious Diseases [R21-AI124868]
- National Institutes of Health [U01AI069918, F31AI124794, F31DA037788, G12MD007583, K01AI093197, K01AI131895, K23EY013707, K24AI065298, K24AI118591, K24DA000432, KL2TR000421, M01RR000052, N01CP01004, N02CP055504, N02CP91027, P30AI027757, P30AI027763, P30AI027767, P30AI036219, P30AI050410]
- Agency for Healthcare Research and Quality, USA [90047713]
- Health Resources and Services Administration, USA [90051652]
- Canadian Institutes of Health Research, Canada [CBR-86906, CBR-94036, HCP-97105, TGF-96118]
- Ontario Ministry of Health and Long Term Care
- Government of Alberta, Canada
- National Cancer Institute
- National Institute for Mental Health
- National Institute on Drug Abuse
- Centers for Disease Control and Prevention, USA [CDC-200-2006-18797, CDC-200-2015-63931]
- [P30AI094189]
- [P30AI110527]
- [P30MH62246]
- [R01AA016893]
- [R01CA165937]
- [R01DA011602]
- [R01DA012568]
- [R01 AG053100]
- [R24AI067039]
- [U01AA013566]
- [U01AA020790]
- [U01AI031834]
- [U01AI034989]
- [U01AI034993]
- [U01AI034994]
- [U01AI035004]
- [U01AI035039]
- [U01AI035040]
- [U01AI035041]
- [U01AI035042]
- [U01AI037613]
- [U01AI069432]
- [U01AI069434]
- [U01AI103390]
- [U01AI103397]
- [U01AI103401]
- [U01AI103408]
- [U01DA03629]
- [U01DA036935]
- [U01HD032632]
- [U10EY008057]
- [U10EY008052]
- [U10EY008067]
- [U24AA020794]
- [U54MD007587]
- [UL1RR024131]
- [UL1TR000004]
- [UL1TR000083]
- [UL1TR000454]
- [UM1AI035043]
- [Z01CP010214]
- [Z01CP010176]
- [U01AI037984]
- [U01AI038855]
- [U01AI038858]
- [U01AI042590]
- [U01AI068634]
- [U01AI068636]
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Background: Hepatitis B virus (HBV) infection is a leading cause of end-stage liver disease (ESLD) and hepatocellular carcinoma (HCC) in HIV. Factors contributing to the high rates of liver complications among HIV/HBV-coinfected individuals remain unknown. Setting: North American AIDS Cohort Collaboration on Research and Design. Methods: We performed a retrospective cohort study among HIV/HBV-coinfected patients in 10 US and Canadian cohorts of the North American AIDS Cohort Collaboration on Research and Design that validated ESLD (ascites, spontaneous bacterial peritonitis, variceal hemorrhage, and/or hepatic encephalopathy) and HCC diagnoses from 1996 to 2010. Multivariable Cox regression was used to examine adjusted hazard ratios [aHRs with 95% confidence interval (CIs)] of liver complications (first occurrence of ESLD or HCC) associated with hypothesized determinants and with increasing durations of HIV suppression (<= 500 copies/mL). Results: Among 3573 HIV/HBV patients with 13,790 person-years of follow-up, 111 liver complications occurred (incidence rate = 8.0 [95% CI: 6.6 to 9.7] events/1000 person-years). Rates of liver complication were increased with non-black/non-Hispanic race [aHR = 1.76 (1.13-2.74)], diabetes mellitus [aHR = 2.07 (1.20-3.57)], lower timeupdated CD4 cell count [<200 cells/mm(3) : aHR = 2.59 (1.36-4.91); 201-499 cells/mm(3) : aHR = 1.75 (1.01-3.06) versus >= 500 cells/mm(3)], heavy alcohol use [aHR = 1.58 (1.04-2.39)], and higher FIB-4 at start of follow-up [>3.25: aHR = 9.79 (5.73-16.74); 1.45-3.25: aHR = 3.20 (1.87-5.47) versus FIB-4 <1.45]. HIV suppression for >= 6 months was associated with lower liver complication rates compared with those with unsuppressed HIV [aHR = 0.56 (0.35-0.91)]. Conclusions: Non-black/non-Hispanic race, diabetes, lower CD4 cell count, heavy alcohol use, and advanced liver fibrosis were determinants of liver complications among HIV/HBV patients. Sustained HIV suppression should be a focus for HIV/HBV-coinfected patients to reduce the risks of ESLD/HCC.
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