4.6 Article

Antioxidant activity of phenolic extracts from different cultivars of Italian onion (Allium cepa) and relative human immune cell proliferative induction

Journal

PHARMACEUTICAL BIOLOGY
Volume 54, Issue 5, Pages 799-806

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.3109/13880209.2015.1080733

Keywords

-

Funding

  1. Fondazione Cassa di Risparmio di Perugia [2013.0222.021]

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Chemistry, Multidisciplinary

Chromatographic Characterization and In Vitro Bioactivity Evaluation of Lactobacillus helveticus Hydrolysates upon Fermentation of Different Substrates

Federica Ianni, Alessandra Anna Altomare, Beniamino T. Cenci-Goga, Francesca Blasi, Luca Grispoldi, Luca Regazzoni, Lina Cossignani

Summary: This study investigated the proteolytic activity of Lactobacillus helveticus strains in producing bioactive peptides from different fermentation substrates, highlighting potential variations in functional effects based on fermentation parameters.

APPLIED SCIENCES-BASEL (2021)

Article Biochemistry & Molecular Biology

Optimized Extraction of Amikacin from Murine Whole Blood

Roccaldo Sardella, Styliani Xiroudaki, Laura Mercolini, Samuele Sabbatini, Claudia Monari, Stefano Perito, Federica Ianni, Anna Vecchiarelli, Stefano Giovagnoli

Summary: This study described an optimized method for extracting AMK from murine whole blood, achieving nearly quantitative (95%) extraction of the drug by using RP-HPLC-UV detection and derivatization with 1-fluoro-2,4-dinitrobenzene. The extraction yield was significantly improved by the addition of 5% ammonium hydroxide in a hydro-organic solution with acetonitrile.

MOLECULES (2021)

Article Engineering, Chemical

Is the Household Microwave Recommended to Obtain Antioxidant-Rich Extracts from Lycium barbarum Leaves?

Luna Pollini, Federica Ianni, Giuseppa Verducci, Francesca Blasi, Lina Cossignani

Summary: This study investigated the effect of household microwave-assisted extraction on the phenolic content and antioxidant activity of Lycium barbarum leaf extracts. The results showed that the solid/liquid ratio and time positively influenced the analytical parameters, while microwave power was inversely correlated with the investigated responses. The study implications suggest that microwave extraction conditions should be carefully monitored to obtain bioactive-rich aqueous extracts with high antioxidant activity.

PROCESSES (2021)

Article Agriculture, Multidisciplinary

LC/MS Q-TOF Metabolomic Investigation of Amino Acids and Dipeptides in Pleurotus ostreatus Grown on Different Substrates

Roberto Maria Pellegrino, Francesca Blasi, Paola Angelini, Federica Ianni, Husam B. R. Alabed, Carla Emiliani, Roberto Venanzoni, Lina Cossignani

Summary: The well-established correlation between diet and health has led to an interest in seeking new health-promoting functional foods. This study investigated the metabolomic profile of Pleurotus ostreatus grown on different substrates and identified essential amino acids and dipeptides as potential bioactive compounds. The expression of these compounds differed significantly depending on the substrate, suggesting a potential strategy for obtaining enriched mushrooms or functional ingredients.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Apple Pomace as Valuable Food Ingredient for Enhancing Nutritional and Antioxidant Properties of Italian Salami

Luca Grispoldi, Federica Ianni, Francesca Blasi, Luna Pollini, Silvia Crotti, Deborah Cruciani, Beniamino Terzo Cenci-Goga, Lina Cossignani

Summary: Apple pomace, a by-product of apple juice manufacturing, contains valuable phenolic compounds with antioxidant activity. Adding dried apple pomace to pork meat for salami production improves its fiber and phenol content, lowers fat and calories, and maintains good sensory qualities.

ANTIOXIDANTS (2022)

Article Infectious Diseases

Untargeted Metabolomics Used to Describe the Chemical Composition, Antioxidant and Antimicrobial Effects of Extracts from Pleurotus spp. Mycelium Grown in Different Culture Media

Giancarlo Angeles Flores, Carolina Elena Girometta, Gaia Cusumano, Paola Angelini, Bruno Tirillini, Federica Ianni, Francesca Blasi, Lina Cossignani, Roberto Maria Pellegrino, Carla Emiliani, Roberto Venanzoni, Giuseppe Venturella, Pasqualina Colasuonno, Fortunato Cirlincione, Maria Letizia Gargano, Gokhan Zengin, Alessandra Acquaviva, Simonetta Cristina Di Simone, Giustino Orlando, Luigi Menghini, Claudio Ferrante

Summary: This study investigated the effect of different media on the production of secondary metabolites, antimicrobial, and antioxidant activity in Pleurotus species. The results showed that the metabolic pathways of Pleurotus species are strongly influenced by the chemical composition of the growth substrate. The mushroom extracts exhibited antibacterial effects against Escherichia coli and were sensitive to certain dermatophytes. Further research is needed to explore the influence of growth substrate on the antimicrobial and antioxidant properties of Pleurotus species.

ANTIBIOTICS-BASEL (2022)

Article Agriculture, Multidisciplinary

In vitro anti-obesity activity by pancreatic lipase inhibition - Simple HPLC approach using EVOO as natural substrate

Francesca Blasi, Federica Ianni, Luciano Mangiapelo, Nicola Pinna, Lina Cossignani

Summary: This study proposes a new analytical method for quantifying the digestion products of pancreatic lipase (PL) in a direct and rapid manner. The method utilizes extra-virgin olive oil triacylglycerol (TAG) as a natural substrate and measures PL activity by monitoring the levels of remaining TAGs and formed free fatty acids (FFAs). The method validation demonstrates its suitability for quantitative purposes and it is successfully applied to evaluate the inhibitory effect of an apple pomace extract.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2023)

Article Biochemistry & Molecular Biology

Unconventional Extraction of Total Non-Polar Carotenoids from Pumpkin Pulp and Their Nanoencapsulation

Nicola Pinna, Federica Ianni, Francesca Blasi, Arianna Stefani, Michela Codini, Stefano Sabatini, Aurelie Schoubben, Lina Cossignani

Summary: This research investigated the impact of unconventional ultrasound-assisted extraction (UAE) and microwave-assisted extraction techniques on the recovery of total non-polar carotenoids from Cucurbita moschata pulp. The study found that UAE with a binary mixture was the most successful extracting technique. Solid lipid nanoparticles were also optimized for encapsulating the extract, showing potential for increased intestinal absorption.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

Environmentally Sustainable Achiral and Chiral Chromatographic Analysis of Amino Acids in Food Supplements

Ina Varfaj, Andrea Carotti, Luciano Mangiapelo, Lina Cossignani, Agnese Taticchi, Antonio Macchiarulo, Federica Ianni, Roccaldo Sardella

Summary: Two LC methods were developed for the analysis of achiral and chiral components of amino acids in a food supplement. Both methods performed well for all eight amino acids, confirming the consistency of amino acid content with manufacturer's declaration. Additionally, a two-dimensional achiral-chiral configuration was proven to be possible in practice, making the methods more environmentally sustainable.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

Optimization of Ultrasound-Assisted Extraction of Chlorogenic Acid from Potato Sprout Waste and Enhancement of the In Vitro Total Antioxidant Capacity

Luciano Mangiapelo, Francesca Blasi, Federica Ianni, Carolina Barola, Roberta Galarini, Ghaid W. A. Abualzulof, Roccaldo Sardella, Claudia Volpi, Lina Cossignani

Summary: Potato sprouts, an underutilized by-product of potato processing, were found to have potential for the recovery of caffeoyl-quinic acids (CQAs), a family of polyphenols with well-recognized biological activities. The predominant compound 5-CQA was successfully extracted using Ultrasound-Assisted Extraction (UAE) under optimized conditions. The study revealed the critical influence of factors such as solid/solvent ratio, water content, and extraction time on the efficiency of extraction.

ANTIOXIDANTS (2023)

Article Biochemistry & Molecular Biology

Effect of Cocoa Roasting on Chocolate Polyphenols Evolution

Alessandro La Mantia, Federica Ianni, Aurelie Schoubben, Marco Cespi, Klemen Lisjak, Davide Guarnaccia, Roccaldo Sardella, Paolo Blasi

Summary: Cocoa and chocolate antioxidants may contribute to human health by improving blood flow, reducing blood pressure and glycemia, and enhancing cognitive function. However, the polyphenol content in cocoa and chocolate is reduced during the production process. This study investigated the changes in polyphenol content during chocolate production, focusing on roasting. Results showed a bell-shaped curve for the total polyphenol content and antioxidant power, with an increase followed by a decrease at different roasting temperatures. Roasting released epicatechin from oligomers, but also led to epicatechin degradation.

ANTIOXIDANTS (2023)

Article Infectious Diseases

Fomitopsis officinalis: Spatial (Pileus and Hymenophore) Metabolomic Variations Affect Functional Components and Biological Activities

Giancarlo Angeles Flores, Gaia Cusumano, Federica Ianni, Francesca Blasi, Paola Angelini, Lina Cossignani, Roberto Maria Pellegrino, Carla Emiliani, Roberto Venanzoni, Gokhan Zengin, Alessandra Acquaviva, Simonetta Cristina Di Simone, Maria Loreta Libero, Giustino Orlando, Luigi Menghini, Claudio Ferrante

Summary: Fomitopsis officinalis is a medicinal mushroom species commonly used in traditional European medicine. This study investigates the spatial metabolic differences in its mushroom parts and the composition of specialized metabolites in the extracts. The apical part of the mushroom contains the highest amount of phenolic compounds and exhibits the strongest antiradical and antimicrobial properties. The extracts from F. officinalis are valuable sources of primary and secondary metabolites, suggesting potential applications in antioxidant and antimicrobial food supplements.

ANTIBIOTICS-BASEL (2023)

Article Plant Sciences

Effect of Different Drying Treatments and Sieving on Royal Gala Apple Pomace, a Thickening Agent with Antioxidant Properties

Lina Cossignani, Federica Ianni, Francesca Blasi, Luna Pollini, Alessandro Di Michele, Cinzia Pagano, Maurizio Ricci, Luana Perioli

Summary: There is currently a growing interest in finding natural derived materials as substitutes for microplastics. This study investigated the use of thickening agents derived from agri-food waste and apple pomace. The study found that oven dried apple pomace (250-400 μm) or homogenized and freeze-dried (>400 μm) samples had the highest total phenol content, antioxidant capacity, and phenol content. These samples were also able to form stable hydrogels, with the sample dried at 55 degrees C showing the best performance. The study suggests that oven dried apple pomace could be a promising stabilizing material with potential applications in food, cosmetics, and nutraceuticals.

PLANTS-BASEL (2023)

Article Food Science & Technology

Valorization of Pumpkin Byproducts: Antioxidant Activity and Carotenoid Characterization of Extracts from Peel and Filaments

Nicola Pinna, Federica Ianni, Roberto Selvaggini, Stefania Urbani, Michela Codini, Luca Grispoldi, Beniamino Terzo Cenci-Goga, Lina Cossignani, Francesca Blasi

Summary: Pumpkin is not only a food rich in nutrients, but also contains bioactive compounds that have a wide range of health-promoting effects. Peel and filaments of pumpkin varieties were found to be a good source of beta-carotene and other carotenoids, as well as having antioxidant activity. These pumpkin byproducts could be valuable in the development of novel functional food products.

FOODS (2023)

Article Biochemistry & Molecular Biology

Ultrasound-Assisted Extraction and Characterization of Polyphenols from Apple Pomace, Functional Ingredients for Beef Burger Fortification

Luna Pollini, Francesca Blasi, Federica Ianni, Luca Grispoldi, Simone Moretti, Alessandra Di Veroli, Lina Cossignani, Beniamino Terzo Cenci-Goga

Summary: There is a growing interest in using agri-food waste to extract bioactive compounds with potential health benefits. This study successfully recovered functional molecules from apple pomace using ultrasound-assisted extraction (UAE) and added the extracted apple pomace, rich in dietary fiber, as a fortifying agent for beef burgers. The results showed that the fortified burgers had improved phenol content, antioxidant activity, color, and sensory characteristics.

MOLECULES (2022)

No Data Available