Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma

miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2

(2018) Liang Wu et al.   Cell Death & Disease

Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts

(2017) Georgios S. Markopoulos et al.   EXPERIMENTAL GERONTOLOGY

Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells

(2017) Iman Azimi et al.   Scientific Reports

Oxidative stress, microRNAs and cytosolic calcium homeostasis

(2016) Alessandra Magenta et al.   CELL CALCIUM

Decreased expression of microRNA-29 family in leiomyoma contributes to increased major fibrillar collagen production

(2016) Erica E. Marsh et al.   FERTILITY AND STERILITY

Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma

(2016) Tsai-Der Chuang et al.   FERTILITY AND STERILITY

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas

(2016) V. Vidimar et al.   Science Advances

MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix

(2016) Mara Mancini et al.   Aging-US

Quantitative and integrated proteome and microRNA analysis of endothelial replicative senescence

(2015) Ramesh Yentrapalli et al.   Journal of Proteomics

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Inactivation of AKT Induces Cellular Senescence in Uterine Leiomyoma

(2014) Xiaofei Xu et al.   ENDOCRINOLOGY

MitomiRs in human inflamm-aging: A hypothesis involving miR-181a, miR-34a and miR-146a

(2014) Maria Rita Rippo et al.   EXPERIMENTAL GERONTOLOGY

Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway

(2014) Xin Xu et al.   Molecular Cancer

Anti-miR182 Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An In Vivo Study in Orthotopic Xenografts of Nude Mice

(2014) X. Xu et al.   MOLECULAR CANCER THERAPEUTICS

De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome

(2014) Ghayda M Mirzaa et al.   NATURE GENETICS

MK-2206, an AKT Inhibitor, Promotes Caspase-Independent Cell Death and Inhibits Leiomyoma Growth

(2013) Elizabeth C. Sefton et al.   ENDOCRINOLOGY

Oxidative Stress and MicroRNAs in Vascular Diseases

(2013) Alessandra Magenta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Akt-associated microRNAs

(2012) Min Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5

(2012) Tsai-Der Chuang et al.   ENDOCRINE-RELATED CANCER

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma

(2012) Zhaojian Liu et al.   JOURNAL OF PATHOLOGY

Role of MicroRNA-182 in Posterior Uveal Melanoma: Regulation of Tumor Development through MITF, BCL2 and Cyclin D2

(2012) Dongsheng Yan et al.   PLoS One

MicroRNA-182-5p targets a network of genes involved in DNA repair

(2012) K. Krishnan et al.   RNA

MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit

(2011) X Li et al.   CELL DEATH AND DIFFERENTIATION

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

(2011) Alyssa L. Kennedy et al.   MOLECULAR CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation

(2010) J-J Lee et al.   CELL DEATH AND DIFFERENTIATION

Regulation of HMGA1 Expression by MicroRNA-296 Affects Prostate Cancer Growth and Invasion

(2010) Jian-Jun Wei et al.   CLINICAL CANCER RESEARCH

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

(2010) Patryk Moskwa et al.   MOLECULAR CELL

Profiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas

(2010) Jiri Zavadil et al.   PLoS One

Alterations in microRNA expression in stress-induced cellular senescence

(2009) Guorong Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics

(2009) Alberto Revelli et al.   Reproductive Biology and Endocrinology

Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia

(2008) A. Mayer et al.   CANCER RESEARCH