MicroRNAs (miRNAs) in cancer invasion and metastasis: therapeutic approaches based on metastasis-related miRNAs

The Epidermal Growth Factor Receptor Responsive miR-125a Represses Mesenchymal Morphology in Ovarian Cancer Cells

(2015) Karen D. Cowden Dahl et al.   NEOPLASIA

Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression

(2011) Andreas Scheel et al.   CELL CYCLE

Stable expression of miR-200c alone is sufficient to regulate TCF8 (ZEB1) and restore E-cadherin expression

(2011) Gregory J. Hurteau et al.   CELL CYCLE

MicroRNA-206 Is Associated With Invasion and Metastasis of Lung Cancer

(2010) Xiaochen Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis

(2010) Zheng-sheng Wu et al.   BMC CANCER

Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells

(2010) Lili Jiang et al.   BMC CANCER

Dysregulated miR-183 inhibits migration in breast cancer cells

(2010) Aoife J Lowery et al.   BMC CANCER

Role of anti-oncomirs miR-143 and -145 in human colorectal tumors

(2010) Y Akao et al.   CANCER GENE THERAPY

MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells

(2010) Gang Li et al.   CANCER LETTERS

miR-126 functions as a tumour suppressor in human gastric cancer

(2010) Runhua Feng et al.   CANCER LETTERS

Downregulation of MicroRNA miR-520h by E1A Contributes to Anticancer Activity

(2010) Jen-Liang Su et al.   CANCER RESEARCH

Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis

(2010) Scott Valastyan et al.   CANCER RESEARCH

miR-146a Suppresses Invasion of Pancreatic Cancer Cells

(2010) Y. Li et al.   CANCER RESEARCH

Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34

(2010) J. F. Wiggins et al.   CANCER RESEARCH

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

(2010) Nobuyoshi Kosaka et al.   CANCER SCIENCE

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

(2010) Ji-guang Zhang et al.   CLINICA CHIMICA ACTA

Circulating Nucleic Acids as a Potential Source for Cancer Biomarkers

(2010) V. Vlassov et al.   CURRENT MOLECULAR MEDICINE

The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2

(2010) Carmen Chak–Lui Wong et al.   GASTROENTEROLOGY

An inhibitory effect of miR-22 on cell migration and invasion in ovarian cancer

(2010) Jun Li et al.   GYNECOLOGIC ONCOLOGY

miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice

(2010) Zhipeng Meng et al.   HEPATOLOGY

MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2

(2010) Linhui Liang et al.   HEPATOLOGY

miR-10b Targets Tiam1

(2010) Charlotte H. Moriarty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy

(2010) Ondrej Slaby et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression

(2010) Bao Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Let-7g targets collagen type I α2 and inhibits cell migration in hepatocellular carcinoma

(2010) Junfang Ji et al.   JOURNAL OF HEPATOLOGY

Loss of MicroRNA-192 Promotes Fibrogenesis in Diabetic Nephropathy

(2010) A. Krupa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of miR-200c Expression Induces an Aggressive, Invasive, and Chemoresistant Phenotype in Non-Small Cell Lung Cancer

(2010) P. Ceppi et al.   MOLECULAR CANCER RESEARCH

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

(2010) Li Ma et al.   NATURE BIOTECHNOLOGY

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA

(2010) Jie Ding et al.   NATURE CELL BIOLOGY

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells

(2010) F Yu et al.   ONCOGENE

miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers

(2010) G Vetter et al.   ONCOGENE

The Tumor Suppressors p53, p63, and p73 Are Regulators of MicroRNA Processing Complex

(2010) Lakshmanane Boominathan   PLoS One

The Regulation of miRNA-211 Expression and Its Role in Melanoma Cell Invasiveness

(2010) Joseph Mazar et al.   PLoS One

microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling

(2010) Z. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network Modeling Identifies Molecular Functions Targeted by miR-204 to Suppress Head and Neck Tumor Metastasis

(2010) Younghee Lee et al.   PLoS Computational Biology

MiR-218 Inhibits Invasion and Metastasis of Gastric Cancer by Targeting the Robo1 Receptor

(2010) Jun Tie et al.   PLoS Genetics

Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas

(2009) Soeren Torge Mees et al.   ANNALS OF SURGICAL ONCOLOGY

MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1

(2009) Heesang Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells

(2009) Tao Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-21as a key regulator of oncogenic processes

(2009) S. Duygu Selcuklu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs

(2009) Hongping Xia et al.   BRAIN RESEARCH

MicroRNA function in cancer: oncogene or a tumor suppressor?

(2009) Sylvia K. Shenouda et al.   CANCER AND METASTASIS REVIEWS

MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines

(2009) Xiqiang Liu et al.   CANCER LETTERS

Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone

(2009) S. Liu et al.   CANCER RESEARCH

MicroRNA-661, a c/EBP  Target, Inhibits Metastatic Tumor Antigen 1 and Regulates Its Functions

(2009) S. D. N. Reddy et al.   CANCER RESEARCH

Breast Cancer Metastasis Suppressor 1 Up-regulates miR-146, Which Suppresses Breast Cancer Metastasis

(2009) Douglas R. Hurst et al.   CANCER RESEARCH

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

(2009) Scott Valastyan et al.   CELL

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

(2009) R I Aqeilan et al.   CELL DEATH AND DIFFERENTIATION

BMP-6 inhibits microRNA-21 expression in breast cancer through repressing δEF1 and AP-1

(2009) Jun Du et al.   CELL RESEARCH

Suppression of cell growth and invasion by miR-205 in breast cancer

(2009) Hailong Wu et al.   CELL RESEARCH

The role of microRNAs in metastasis and epithelial-mesenchymal transition

(2009) C. P. Bracken et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of RUNX3 Tumor Suppressor Gene Expression in Cutaneous Melanoma

(2009) M. Kitago et al.   CLINICAL CANCER RESEARCH

MicroRNA-21 Regulates the Proliferation and Invasion in Esophageal Squamous Cell Carcinoma

(2009) Y. Hiyoshi et al.   CLINICAL CANCER RESEARCH

AngiomiRs—Key regulators of angiogenesis

(2009) Shusheng Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

(2009) Surabhi Dangi-Garimella et al.   EMBO JOURNAL

miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis

(2009) Christoph A Gebeshuber et al.   EMBO REPORTS

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types

(2009) Richard Hummel et al.   EUROPEAN JOURNAL OF CANCER

The microRNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms

(2009) Isabella Manni et al.   FASEB JOURNAL

Epidermal growth factor receptor-regulated miR-125a-5p - a metastatic inhibitor of lung cancer

(2009) Guofu Wang et al.   FEBS Journal

MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells

(2009) Alessandro Salvi et al.   FEBS Journal

Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis

(2009) Scott Valastyan et al.   GENES & DEVELOPMENT

MicroRNA-125b is a novel negative regulator of p53

(2009) M. T.N. Le et al.   GENES & DEVELOPMENT

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

(2009) D. L. Gibbons et al.   GENES & DEVELOPMENT

Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression

(2009) Xiaoying Zhang et al.   HEPATOLOGY

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

(2009) Florin M. Selaru et al.   HEPATOLOGY

Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma: miR-338 is downregulated

(2009) Xiao-Hui Huang et al.   HEPATOLOGY RESEARCH

DNAzymes and their therapeutic possibilities

(2009) C. W. S. Chan et al.   INTERNAL MEDICINE JOURNAL

MicroRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy

(2009) William C.S. Cho   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

EP300-A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas

(2009) Soeren Torge Mees et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetic regulation of microRNA expression in colorectal cancer

(2009) Eva Bandres et al.   INTERNATIONAL JOURNAL OF CANCER

Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression

(2009) Mick D. Edmonds et al.   INTERNATIONAL JOURNAL OF CANCER

The miR200 Family of MicroRNAs Regulates WAVE3-dependent Cancer Cell Invasion

(2009) Khalid Sossey-Alaoui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-regulation of miR-21 by HER2/neuSignaling Promotes Cell Invasion

(2009) Tzu-Hsuan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ST14(Suppression of Tumorigenicity 14) Gene Is a Target for miR-27b, and the Inhibitory Effect of ST14 on Cell Growth Is Independent of miR-27b Regulation

(2009) Yanfang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-206 Targetsnotch3, Activates Apoptosis, and Inhibits Tumor Cell Migration and Focus Formation

(2009) Guisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

(2009) Angela B Y Hui et al.   LABORATORY INVESTIGATION

MicroRNA-9 reduces cell invasion and E-cadherin secretion in SK-Hep-1 cell

(2009) Tan Hao-Xiang et al.   MEDICAL ONCOLOGY

MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents

(2009) D. R. Cochrane et al.   MOLECULAR CANCER THERAPEUTICS

Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

(2009) Fumitaka Takeshita et al.   MOLECULAR THERAPY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

MicroRNAs as potential cancer therapeutics

(2009) P Trang et al.   ONCOGENE

Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties

(2009) C Coulouarn et al.   ONCOGENE

Downregulation of miR-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancer

(2009) X-F Li et al.   ONCOGENE

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases

(2009) Derek M. Dykxhoorn et al.   PLoS One

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

(2009) Miguel F. Segura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines

(2008) M. Crawford et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiR-92b and miR-9/9* Are Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors

(2008) Dvora Nass et al.   BRAIN PATHOLOGY

miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells

(2008) Na Li et al.   CANCER LETTERS

MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions

(2008) S. D. N. Reddy et al.   CANCER RESEARCH

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

(2008) T. Papagiannakopoulos et al.   CANCER RESEARCH

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

(2008) Shuomin Zhu et al.   CELL RESEARCH

MicroRNA Expression Profiles in Serous Ovarian Carcinoma

(2008) E. J. Nam et al.   CLINICAL CANCER RESEARCH

Cellular Delivery In Vivo of siRNA-Based Therapeutics

(2008) A. Aigner   CURRENT PHARMACEUTICAL DESIGN

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

Recent development of nonviral gene delivery systems with virus-like structures and mechanisms

(2008) Keiji Itaka et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

MicroRNA-183 regulates Ezrin expression in lung cancer cells

(2008) Guofu Wang et al.   FEBS LETTERS

MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma

(2008) Wei-Chih Tsai et al.   HEPATOLOGY

MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31

(2008) Srinivas Veerla et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma

(2008) Aaron J. Schetter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism

(2008) Shuji Fujita et al.   JOURNAL OF MOLECULAR BIOLOGY

MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

(2008) G. Gabriely et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-155 Is Regulated by the Transforming Growth Factor  /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

(2008) W. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths

(2008) Danish Sayed et al.   MOLECULAR BIOLOGY OF THE CELL

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

(2008) Jonathan B. Johnnidis et al.   NATURE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

(2008) Qihong Huang et al.   NATURE CELL BIOLOGY

The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

(2008) Désirée Bonci et al.   NATURE MEDICINE

Stable knockdown of microRNA in vivo by lentiviral vectors

(2008) Bernhard Gentner et al.   NATURE METHODS

An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation

(2008) F Talotta et al.   ONCOGENE

Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells

(2008) D Bhaumik et al.   ONCOGENE

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins

(2008) S. Sengupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer

(2008) J. A. Foekens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE

The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition

(2008) Emily L. Paterson et al.   TheScientificWorldJOURNAL

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE

A microRNA expression ratio defining the invasive phenotype in bladder tumors

(2008) Lori A. Neely et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS