Astrocytes: new targets of melanocortin 4 receptor actions

Potent Anti-Inflammatory and Neuroprotective Effects of TGF- 1 Are Mediated through the Inhibition of ERK and p47phox-Ser345 Phosphorylation and Translocation in Microglia

(2014) L. Qian et al.   JOURNAL OF IMMUNOLOGY

Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity

(2013) Bhavaani Jayaram et al.   JOURNAL OF APPLIED PHYSIOLOGY

Melanocortin-4 Receptor Regulates Hippocampal Synaptic Plasticity through a Protein Kinase A-Dependent Mechanism

(2013) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Astrogliosis in the brain of obese Zucker rat: A model of metabolic syndrome

(2013) Daniele Tomassoni et al.   NEUROSCIENCE LETTERS

Effect of NDP-α-MSH on PPAR-γ and –β Expression and Anti-Inflammatory Cytokine Release in Rat Astrocytes and Microglia

(2013) Lila Carniglia et al.   PLoS One

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

(2012) P. Kievit et al.   DIABETES

Brain-gut-adipose-tissue communication pathways at a glance

(2012) C.-X. Yi et al.   Disease Models & Mechanisms

Effects of Leptin and Melanocortin Signaling Interactions on Pubertal Development and Reproduction

(2012) Davelene D. Israel et al.   ENDOCRINOLOGY

Hypothalamic Astrocytes in Obesity

(2012) Cristina García-Cáceres et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

(2012) Esther Fuente-Martín et al.   JOURNAL OF CLINICAL INVESTIGATION

Melanocortin-Induced PKA Activation Inhibits AMPK Activity Via ERK-1/2 and LKB-1 in Hypothalamic GT1-7 Cells

(2012) Ellen Damm et al.   MOLECULAR ENDOCRINOLOGY

Gemfibrozil, a Lipid Lowering Drug, Inhibits the Activation of Primary Human Microglia Via Peroxisome Proliferator-Activated Receptor β

(2012) Malabendu Jana et al.   NEUROCHEMICAL RESEARCH

Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recovery

(2011) Daniela Giuliani et al.   ACTA NEUROPATHOLOGICA

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*

(2011) Alessandra Bitto et al.   CRITICAL CARE MEDICINE

Differential Acute and Chronic Effects of Leptin on Hypothalamic Astrocyte Morphology and Synaptic Protein Levels

(2011) Cristina García-Cáceres et al.   ENDOCRINOLOGY

Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP – Protein kinase A pathway

(2011) Carla Caruso et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Prevention of extracellular ADP-induced ATP accumulation of the cultured rat spinal astrocytes via P2Y(1)-mediated inhibition of AMPK

(2011) Jian Cui et al.   NEUROSCIENCE LETTERS

ACTH is a novel regulator of bone mass

(2010) Carlos M. Isales et al.   Annals of the New York Academy of Sciences

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure

(2010) Jarrad M Scarlett et al.   JOURNAL OF ENDOCRINOLOGY

α-Melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-γ-induced tumor necrosis factor-α expression but not tumor necrosis factor-α receptor expression in cultured hypothalamic neurons

(2010) Carla Caruso et al.   JOURNAL OF NEUROIMMUNOLOGY

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions

(2010) Ivana Machado et al.   PEPTIDES

Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling

(2010) Biaoxin Chai et al.   PEPTIDES

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential

(2009) Annalisa Buffo et al.   BIOCHEMICAL PHARMACOLOGY

Obesity induces functional astrocytic leptin receptors in hypothalamus

(2009) H. Hsuchou et al.   BRAIN

Memory impairment induced by IL-1β is reversed by α-MSH through central melanocortin-4 receptors

(2009) Patricia Verónica Gonzalez et al.   BRAIN BEHAVIOR AND IMMUNITY

Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268

(2009) Daniela Giuliani et al.   BRAIN BEHAVIOR AND IMMUNITY

Gliotransmission: Exocytotic release from astrocytes

(2009) Vladimir Parpura et al.   BRAIN RESEARCH REVIEWS

Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes after Cerebral Ischemia

(2009) Veronika G. Dmitrieva et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mahogunin Ring Finger-1 (MGRN1) E3 Ubiquitin Ligase Inhibits Signaling from Melanocortin Receptor by Competition with Gαs

(2009) Ana B. Pérez-Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Role of Lactate after Cerebral Ischemia

(2009) Carole Berthet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

(2009) Gautam K. Gandhi et al.   JOURNAL OF NEUROCHEMISTRY

Melanocortin potentiates leptin-induced STAT3 signaling via MAPK pathway

(2009) Yan Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes

(2009) Daniela Durand et al.   JOURNAL OF NEUROCHEMISTRY

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Peroxisome Proliferator-Activated Receptor (PPAR)-  Positively Controls and PPAR  Negatively Controls Cyclooxygenase-2 Expression in Rat Brain Astrocytes through a Convergence on PPAR /  via Mutual Control of PPAR Expression Levels

(2009) S. Aleshin et al.   MOLECULAR PHARMACOLOGY

Central control of fever and female body temperature by RANKL/RANK

(2009) Reiko Hanada et al.   NATURE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Update on melanocortin interventions for cachexia: Progress toward clinical application

(2009) Mark Daniel DeBoer   NUTRITION

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

(2009) L. F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Regulation of Pigmentation in Human Epidermal Melanocytes by Functional High-Affinity β-Melanocyte-Stimulating Hormone/Melanocortin-4 Receptor Signaling

(2008) J. D. Spencer et al.   ENDOCRINOLOGY

Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons

(2008) E Guillod-Maximin et al.   JOURNAL OF ENDOCRINOLOGY

Role of α-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation

(2008) Mercedes Lasaga et al.   PEPTIDES

Brain effects of melanocortins☆

(2008) A BERTOLINI et al.   PHARMACOLOGICAL RESEARCH

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Neuroprotective actions of melanocortins: a therapeutic opportunity

(2008) Anna Catania   TRENDS IN NEUROSCIENCES

Regulation of pH in the mammalian central nervous system under normal and pathological conditions: Facts and hypotheses

(2007) Marta Obara et al.   NEUROCHEMISTRY INTERNATIONAL