MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation?

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

(2013) Ralf Nass et al.   ANNALS OF INTERNAL MEDICINE

Use of Growth Hormone Secretagogues to Prevent or Treat the Effects of Aging: Not Yet Ready for Prime Time

(2013) Marc R. Blackman   ANNALS OF INTERNAL MEDICINE

Structure, function and regulation of the melanocortin receptors

(2011) Yingkui Yang   EUROPEAN JOURNAL OF PHARMACOLOGY

Mutually Opposite Signal Modulation by Hypothalamic Heterodimerization of Ghrelin and Melanocortin-3 Receptors

(2011) Anne Rediger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

(2010) Shuwen He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

(2010) Shuwen He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity

(2010) Ming Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

(2010) Liangqin Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Identification and Functional Analysis of Novel Human Growth Hormone Secretagogue Receptor (GHSR) Gene Mutations in Japanese Subjects with Short Stature

(2010) Hiroshi Inoue et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response

(2010) Pierre Roubert et al.   JOURNAL OF ENDOCRINOLOGY

A Pharmacologically Active Monoclonal Antibody against the Human Melanocortin-4 Receptor: Effectiveness After Peripheral and Central Administration

(2010) J. C. Peter et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia

(2010) Timo D. Müller et al.   Journal of Cachexia Sarcopenia and Muscle

Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy

(2009) R Krishna et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors

(2009) Birgitte Holst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor

(2009) Jacques Pantel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GOAT links dietary lipids with the endocrine control of energy balance

(2009) Henriette Kirchner et al.   NATURE MEDICINE

Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation

(2009) Anne Rediger et al.   Obesity Facts

Orally Available Selective Melanocortin-4 Receptor Antagonists Stimulate Food Intake and Reduce Cancer-Induced Cachexia in Mice

(2009) Philipp Weyermann et al.   PLoS One

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR)

(2008) Weixu Zhai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Functional Characterization and Structural Modeling of Obesity Associated Mutations in the Melanocortin 4 Receptor

(2008) Karen Tan et al.   ENDOCRINOLOGY

G protein-coupled receptor dimers: Functional consequences, disease states and drug targets

(2008) Matthew B. Dalrymple et al.   PHARMACOLOGY & THERAPEUTICS