Article
Biochemistry & Molecular Biology
Shuang Liu, Xing Wen, Qihan Huang, Minghui Zhu, Jun Lu
Summary: Cisplatin is an effective chemotherapy drug for solid tumors but also causes various side effects, especially nephrotoxicity. Previous studies have shown a correlation between selenoenzymes and cisplatin-induced renal damage. This study established mouse models with different selenium intake levels and found that selenium deficiency increased sensitivity to cisplatin-induced damage, while selenium supplementation protected against renal injury.
Review
Endocrinology & Metabolism
Fei Wang, Chunyu Li, Shaoxin Li, Lili Cui, Junyu Zhao, Lin Liao
Summary: Selenium is an essential micronutrient for the biosynthesis of selenoproteins in the thyroid, and its deficiency can increase the prevalence of thyroid diseases. Selenium treatment has shown benefits in delaying disease progression and improving quality of life in patients with Graves' orbitopathy. Supplementation with selenium has also been associated with decreased levels of anti-thyroid antibodies and improved thyroid structure in Hashimoto's thyroiditis. However, the anticancer activity of selenium supplements in thyroid cancer remains conflicting and more clinical evidence is needed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physiology
Shichen Huang, Zhiyuan Li, Yuhan Sun, Baiyi Chen, Yuxin Jiang, Feng Hong
Summary: CD34 could serve as a biomarker for islet beta-cells, with its expression and number being inversely correlated with islet alpha-cells. This suggests the potential of CD34 as a diagnostic biomarker for early diabetes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Summary: Pancreatic islets are crucial for maintaining blood glucose levels, with declining function being a characteristic of type 2 diabetes. A detailed proteomic analysis of mouse islets from various genetic or diet-induced models revealed that most proteins are expressed in all strains and diets, but with varying levels due to genetics. Islet mitochondrial function was identified as a major positive indicator of metabolic health across different strains.
Article
Medicine, Research & Experimental
Butian Wei, Xin Zhang, Jiwei Qian, Zhe Tang, Bo Zhang
Summary: Nrf2 is an important intracellular regulator of antioxidant stress, regulating not only antioxidant function but also insulin secretion, proliferation, and differentiation of beta cells, ER stress, and mitochondrial function. Pharmacological activation of Nrf2 has been shown to protect islet cells during different stages of transplantation in experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Physiology
Zi-Meng Li, Xiu-Li Wang, Xiao-Min Jin, Jia-Qiang Huang, Lian-Shun Wang
Summary: Adverse conditions, such as crowding stress, hypoxia, and malnutrition, arise during the intensive aquaculture farming, leading to oxidative stress. Selenium plays a crucial role as an effective antioxidant in fish's defense system against oxidative stress. This paper reviews the physiological functions of selenoproteins, mechanisms of different selenium forms, and the harmful effects of low and high selenium levels in aquaculture. It summarizes the application and research progress of selenium in oxidative stress in aquatic animals, providing scientific references for its anti-oxidative stress application in aquaculture.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natsuki Eguchi, Kimia Damyar, Michael Alexander, Donald Dafoe, Jonathan R. T. Lakey, Hirohito Ichii
Summary: Islet cell transplantation is a favorable therapeutic approach for Type 1 Diabetes, but there are limitations in the process, including oxidative stress that leads to the loss of islet cells. Therefore, exploring the application of antioxidants in transplantation is crucial.
Article
Biochemistry & Molecular Biology
Ying-Chen Huang, Gerald F. Combs Jr, Tung-Lung Wu, Huawei Zeng, Wen-Hsing Cheng
Summary: Optimal selenium status is important for overall health, and it can be influenced by various factors such as food intake pattern, age, sex, and health status. Insufficient intake of selenium can reduce the expression of selenium-containing proteins, while both insufficient and excessive intakes may increase the risk of type 2 diabetes mellitus. Understanding the relationship between selenium status and diabetes risk can inform the establishment of safe and adequate selenium intake.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Nanako Kitabayashi, Shohei Nakao, Yuichiro Mita, Kotoko Arisawa, Takayuki Hoshi, Kiyo-aki Ishii, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito, Takashi Toyama
Summary: Selenoprotein P (SELENOP) is a selenium-containing protein that plays a significant role in pancreatic beta cell function by maintaining the levels of cellular selenoproteins. Knockdown of the Selenop gene resulted in decreased cell viability, insulin levels, and insulin secretion, which were recovered by the addition of selenium. These findings suggest that SELENOP expression is important for the function of pancreatic beta cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Guang-Hui Liu, Dian-Guang Zhang, Xi-Jun Lei, Xiao-Ying Tan, Chang-Chun Song, Hua Zheng, Zhi Luo
Summary: This study investigated the effects of selenium and oxidized fish oil on intestinal lipid metabolism and antioxidant responses in yellow catfish. The results showed that selenium supplementation reduced intestinal tissue damage and lipid accumulation induced by oxidized fish oils. Additionally, selenium alleviated oxidative stress and affected the expression of intestinal selenoproteins. Mechanistically, selenium and oxidized eicosapentaenoic acid influenced glutathione content by affecting the DNA binding ability of activating transcription factor 3 (ATF3) to the slc7a11 promoter.
Article
Immunology
A. Skesters, D. Kustovs, A. Lece, E. Moreino, E. Petrosina, K. D. Rainsford
Summary: This study aimed to assess the tendency of oxidative stress in COVID-19 patients depending on severity. The results showed that patients with severe disease had significantly lower selenium and seleno-protein P levels and higher oxidative stress levels.
INFLAMMOPHARMACOLOGY
(2022)
Article
Oncology
Wenjie Qin, Muxing Kang, Chao Li, Wen Zheng, Qingqu Guo
Summary: This study found that Vanin-1 (VNN1) overexpressing pancreatic cancer cells aggravated the dysfunction of mouse primary islets through the secretion of cysteamine and exosomes. VNN1 was transported into islets through PC cell-derived exosomes and induced beta-cell dedifferentiation through inhibiting AMPK and GAPDH phosphorylation, preventing Sirt1 activation and FoxO1 deacetylation. Moreover, VNN1-overexpressing pancreatic cancer cells further impaired the functions of paraneoplastic islets in vivo. In summary, VNN1 overexpression exacerbates the dysfunction of paraneoplastic islets through oxidative stress and beta-cell dedifferentiation.
Review
Biochemistry & Molecular Biology
Chi Ma, Verena Martinez-Rodriguez, Peter R. Hoffmann
Summary: The selenoprotein family comprises 25 members, with SELENOI being a unique member functioning as an ethanolamine phosphotransferase. SELENOI plays a crucial role in the synthesis of cellular membrane constituents, impacting metabolic reprogramming and proliferative capacity in T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Natsuki Eguchi, Nosratola D. Vaziri, Donald C. Dafoe, Hirohito Ichii
Summary: Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose levels due to impaired pancreatic beta cell function and insulin resistance. Studies have shown that endoplasmic reticulum stress, mitochondrial dysfunction, and oxidative stress play central roles in promoting beta cell dysfunction, with oxidative stress particularly important as beta cells exhibit lower antioxidative capacity. Efforts are being made to understand and counteract the effects of oxidative stress on beta cell health and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jingyi Li, Yuxuan Zheng, Pengze Yan, Moshi Song, Si Wang, Liang Sun, Zunpeng Liu, Shuai Ma, Juan Carlos Izpisua Belmonte, Piu Chan, Qi Zhou, Weiqi Zhang, Guang-Hui Liu, Fuchou Tang, Jing Qu
Summary: The aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes. Single-cell RNA sequencing revealed increased unfolded protein response (UPR) and accumulation of protein aggregates in aged beta-cells. Targeting UPR components may prevent loss of proteostasis, delaying beta-cell aging and preventing aging-related diabetes.
NATIONAL SCIENCE REVIEW
(2021)
Article
Biochemistry & Molecular Biology
Dimitrios Tsitsipatis, Keshav Gopal, Holger Steinbrenner, Lars-Oliver Klotz
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Correction
Biochemistry & Molecular Biology
J. Egea, I. Fabregat, Y. M. Frapart, P. Ghezzi, A. Goerlach, T. Kietzmann, K. Kubaichuk, U. G. Knaus, M. G. Lopez, G. Olaso-Gonzalez, A. Petry, R. Schulz, J. Vina, P. Winyard, K. Abbas, O. S. Ademowo, C. B. Afonso, I. Andreadou, H. Antelmann, F. Antunes, M. Aslan, M. M. Bachschmid, R. M. Barbosa, V. Belousov, C. Berndt, D. Bernlohr, E. Bertran, A. Bindoli, S. P. Bottari, P. M. Brito, G. Carrara, A. I. Casas, A. Chatzi, N. Chondrogiannni, M. Conrad, M. S. Cooke, J. G. Costa, A. Cuadrado, P. My-Chan Dang, B. De Smet, B. Debelec-Butuner, I. H. K. Dias, J. D. Dunn, A. J. Edson, M. El Assar, J. El-Benna, P. Ferdinandy, A. S. Fernandes, K. E. Fladmark, U. Foerstermann, R. Giniatullin, Z. Giricz, A. Gorbe, H. Griffiths, V. Hampl, A. Hanf, J. Herget, P. Hernansanz-Agustin, M. Hillion, J. Huang, S. Ilikay, P. Jansen-Duerr, V. Jaquet, J. A. Joles, B. Kalyanaraman, D. Kaminskyy, M. Karbaschi, M. Kleanthous, L. O. Klotz, B. Korac, K. S. Korkmaz, R. Koziel, D. Kracun, K. H. Krause, V. Kren, T. Krieg, J. Laranjinha, A. Lazou, H. Li, A. Martinez-Ruiz, R. Matsui, G. J. McBean, S. P. Meredith, J. Messens, V. Miguel, Y. Mikhed, I. Milisav, L. Milkovic, A. Miranda-Vizuete, M. Mojovic, M. Monsalve, P. A. Mouthuay, J. Mulvey, T. Muenzel, V. Muzykantov, I. T. N. Nguyen, M. Oelze, N. G. Oliveira, C. M. Palmeira, N. Papaevgeniou, A. Pavicevic, B. Pedre, F. Peyrot, M. Phylactides, G. G. Pircalabioru, A. R. Pitt, H. E. Poulsen, I. Prieto, M. P. Rigobello, N. Robledinos-Anton, L. Rodriguez-Manas, A. P. Rolo, F. Rousset, T. Ruskovska, N. Saraiva, S. Sasson, K. Schroeder, K. Semen, T. Seredenina, A. Shakirzyanova, G. L. Smith, T. Soldati, B. C. Sousa, C. M. Spickett, A. Stancic, M. J. Stasia, H. Steinbrenner, V. Stepanic, S. Steven, K. Tokatlidis, E. Tuncay, B. Turan, F. Ursini, J. Vacek, O. Vanjnerova, K. Valentova, F. Van Breusegem, L. Varisli, E. A. Veal, A. S. Yalcin, O. Yelisyeyeva, N. Zarkovic, M. Zatloukalova, J. Zielonka, R. M. Touyz, A. Papapetropoulos, T. Grune, S. Lamas, H. H. H. W. Schmidt, F. Di Lisa, A. Daiber
Article
Nutrition & Dietetics
Ngoc Anh Hoang, Friederike Richter, Martin Schubert, Stefan Lorkowski, Lars-Oliver Klotz, Holger Steinbrenner
EUROPEAN JOURNAL OF NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Andrea Gille, Abdullah Turkistani, Dimitrios Tsitsipatis, Xiaoqing Hou, Sarah Tauber, Ingrit Hamann, Nadine Urban, Katrin Erler, Holger Steinbrenner, Lars-Oliver Klotz
Article
Biochemistry & Molecular Biology
Holger Steinbrenner, Mustafa Micoogullari, Ngoc Anh Hoang, Ina Bergheim, Lars-Oliver Klotz, Helmut Sies
Article
Biochemistry & Molecular Biology
Helmut Sies
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Helmut Sies
Review
Biochemistry & Molecular Biology
Helmut Sies
Summary: The spatiotemporal control of redox signaling in cells relies on continuous fine-tuning, with molecules like H2O2 playing a key role. Oxidative eustress operates within a specific physiological range, and is managed through both short-term and long-term homeostatic mechanisms to respond to stress.
Article
Biochemistry & Molecular Biology
Sarah Tauber, Maria Katharina Sieckmann, Katrin Erler, Wilhelm Stahl, Lars-Oliver Klotz, Holger Steinbrenner
Summary: The study found that the Se status had no major effect on Nrf2 signaling in HepG2 cells, although electrophiles could enhance the expression of Nrf2 target genes independent of cellular Se status.
Review
Cell Biology
M. Cristina Polidori, Helmut Sies, Luigi Ferrucci, Thomas Benzing
Summary: COVID-19 is a global emergency that can overwhelm healthcare systems worldwide, particularly affecting the elderly. Identifying vulnerable populations is essential for taking targeted actions to address the risks associated with the disease.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Helmut Sies, Fulvio Ursini
Summary: Research on oxidants and electrophiles has shifted focus towards the dynamic maintenance of redox balance and redox eustress, providing mechanistic insight and raising specific questions in the field. Excitement in this area is driven by recent research advancements that shed light on the active concepts related to maintaining physiological health through redox regulation and response to stress, such as viral infections like COVID-19.
Article
Cell Biology
Helmut Sies, Vsevolod V. Belousov, Navdeep S. Chandel, Michael J. Davies, Dean P. Jones, Giovanni E. Mann, Michael P. Murphy, Masayuki Yamamoto, Christine Winterbourn
Summary: This article discusses the key issues associated with identifying the physiological roles of oxidants, with a focus on H2O2 and O-2(.-). The article emphasizes the need for more precise measurement of oxidants and specific identification of their signaling targets. It also highlights the importance of inter-organellar communication and the contribution of environmental exposures. Development of tools for real-time detection and quantification of individual oxidants is crucial for achieving these goals.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anne Sophie Scheller, Thilo Magnus Philipp, Lars-Oliver Klotz, Holger Steinbrenner
Summary: SELENBP1 and CBS are reciprocally regulated during the spontaneous differentiation of human colorectal adenocarcinoma cells, paralleling their opposing regulation in colorectal cancer. Butyrate exposure imitates some aspects of spontaneous differentiation but does not elicit the same expression patterns of genes encoding H2S-modulating enzymes.
Review
Biochemistry & Molecular Biology
Thilo Magnus Philipp, Anne Sophie Scheller, Niklas Krafczyk, Lars-Oliver Klotz, Holger Steinbrenner
Summary: Tumor cells develop various metabolic adaptations to cope with increased demands and enhance stress resilience, including dysregulation of sulfur metabolism leading to elevated levels of volatile sulfur compounds (VSCs) in cancer patients. Methanethiol, the predominant cancer-associated VSC, has been proposed as a promising biomarker for non-invasive cancer diagnosis. Gut bacteria, such as Fusobacterium nucleatum, are the major source of methanethiol exposure, and proteins like SELENBP1 and METTL7B are involved in the production and degradation of methanethiol.
Review
Biochemistry & Molecular Biology
Dimitrios Tsitsipatis, Lars-Oliver Klotz, Holger Steinbrenner
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)