Article
Chemistry, Multidisciplinary
Jia-hui Tian, Qian Wu, Yong-xiang He, Qi-ying Shen, Mubarak Rekep, Gui-ping Zhang, Jian-dong Luo, Qin Xue, Ying-hua Liu
Summary: Zonisamide (ZNS) attenuates ER stress-induced apoptosis, improves cardiac dysfunction and hypertrophy in diabetic mice, suggesting its protective effects on diabetic cardiomyopathy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Tao Wang, Jinhua Wu, Wei Dong, Mengwen Wang, Xiaodan Zhong, Wenjun Zhang, Lei Dai, Yang Xie, Yujian Liu, Xingwei He, Wanjun Liu, Thati Madhusudhan, Hesong Zeng, Hongjie Wang
Summary: This study identifies the previously unknown function of the MEK/ERK pathway in regulating ER stress in diabetic cardiomyopathy. MEK inhibition with U0126 can ameliorate diabetic cardiomyopathy by regulating the IRE1 alpha-XBP1s pathway and promoting XBP1s' nuclear accumulation, indicating a potential therapeutic target for DCM.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Reza Aslani, Mojtaba Amani, Neghin Masrori, Mohammad Hossein Boskabady, Hossein Ali Ebrahimi, Leila Chodari
Summary: The study revealed that crocin and dexamethasone can alleviate airway inflammation and suppress ER stress markers. In the OVA-Cr100 group, the inhibitory effects on ER stress apoptotic markers were comparable to the OVA-Dexa group.
Correction
Chemistry, Multidisciplinary
E. Shuang, Quan-Xing Mao, Jian-Hua Wang, Xu-Wei Chen
Summary: This study corrected the research on carbon dots with tunable dual emissions and explored their application in specific imaging of endoplasmic reticulum polarity.
Article
Immunology
Xue Han, Wenwei Zhou, Jiajia Zhang, Yu Tu, Jiajia Wei, Ruyi Zheng, Jian Zhu, Diyun Xu, Huazhong Ying, Gaojun Wu, Qiaojuan Shi, Guang Liang
Summary: This study demonstrates that linderalactone can prevent diabetic cardiomyopathy by inhibiting myocardial hypertrophy and inflammation through modulation of the MAPK/ATF6 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Shun Wu, Dingchun Lu, Babu Gajendran, Qilan Hu, Jian Zhang, Shengquan Wang, Minzhen Han, Yini Xu, Xiangchun Shen
Summary: Diabetic cardiomyopathy (DCM) is a common complication in diabetic patients leading to heart failure, primarily caused by endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism. Tanshinone II A (Tan IIA), the main active component of a Chinese medicine called Salviae miltiorrhizae radix et rhizome, has been found to have protective effects against cardiovascular disease and diabetes. This study aimed to investigate whether Tan IIA alleviates ERS-mediated DCM via SIRT1, and the results showed that Tan IIA improved the pathological changes in diabetic mice hearts and inhibited ERS-related protein and mRNA expression.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Masahide Konno, Yuri Sakata, Taku Ozaki
Summary: The present study demonstrates that the activation of mitochondrial calpain-5 triggers the truncation of caspase-4, suggesting that mitochondrial calpain-5 regulates the downstream pathway of caspase-4, including cell death and the inflammatory cascade. These findings provide new insights into ER-stress-related diseases such as Alzheimer's disease and cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Masahiro Kawahara, Ken-ichiro Tanaka, Midori Kato-Negishi
Summary: Copper is an essential trace element that plays critical roles in brain functions, working alongside zinc to modulate neuronal transmission at synapses for information processing. However, low concentrations of copper during transient global ischemia exacerbate zinc-induced neurotoxicity, leading to ER stress, SAPK/JNK pathway activation, and increased ROS production. The collaborative roles of copper in zinc-induced neurotoxicity at synapses and its contribution to the pathogenesis of vascular dementia are significant topics for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Wenhan Wang, Tinghao Liu, Yuanyuan Liu, Lechu Yu, Xiaoqing Yan, Wenya Weng, Xuemian Lu, Chi Zhang
Summary: The study demonstrated that astaxanthin (AST) can attenuate ethanol-induced cardiac endoplasmic reticulum (ER) stress and subsequent apoptosis, alleviating chronic excessive ethanol consumption-induced cardiomyopathy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xinquan Li, Yaxun Cheng, Yunpeng Qin, Huawu Gao, Guangyun Wang, Hang Song, Yan Wang, Biao Cai
Summary: The study investigated the potential neuroprotective role of chrysophanol in the treatment of Alzheimer's disease by regulating endoplasmic reticulum stress.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wanpeng Li, Peiling Liu, Huilin Liu, Fuchun Zhang, Fu Yicheng, Yicheng Fu
Summary: Through analysis of microarray data, we identified potential biomarkers related to endoplasmic reticulum stress and explored their molecular mechanisms in myocardial fibrosis. Inflammatory immune imbalance and T-cell subsets play important roles in the progression of fibrosis. Additionally, we identified seven hub genes that may be involved in immune-related mechanisms.
Article
Biochemistry & Molecular Biology
Vineta Fellman, Rishi Banerjee, Kai-Lan Lin, Ilari Pulli, Helen Cooper, Henna Tyynismaa, Jukka Kallijarvi
Summary: Whole genome sequencing identified a homozygous SERAC1 mutation in a newborn with MEGDHEL syndrome, leading to severe mitochondrial structural and functional abnormalities, which resulted in multiorgan failure.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Jing Meng, Xiaoying Song, Guoliang Yan, Haihui Wang, Haitao Li, Danfei Lou
Summary: The study showed that dendrobine reduced endothelial cell apoptosis induced by ERS through upregulating miR-381-3p expression, partially restoring cell proliferation level, and mediated by caspase-4. These findings provide new insights into the causes of endothelial cell apoptosis in AS and highlight the therapeutic potential of dendrobine in treating AS.
Article
Cell Biology
Shukun Sun, Yu Han, Chuanxin Zhang, Han Liu, Bailu Wang, Shengchuan Cao, Qiuhuan Yuan, Shujian Wei, Yuguo Chen
Summary: ADK inhibition reduces inflammation and necroptotic acinar cell death in severe acute pancreatitis via the adenosine A(2A) receptor/ER stress pathway, providing new clues for potential therapeutic targets for SAP.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Mohamed Khairy Abdel-Rafei, Noura Magdy Thabet, Laila Ahmed Rashed, Enas Mahmoud Moustafa
Summary: The combination of CAN and gamma-IR shows significant anti-tumor potential in inhibiting HepG2 cell proliferation and survival. It works by modulating glycolytic metabolism, autophagy, and apoptosis pathways, as well as disrupting signaling pathways related to tumor progression, ultimately improving treatment outcomes.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Meeting Abstract
Biophysics
Jessica L. Cao, Stephanie Adaniya, Amy K. Landi, Dong Qin Yang, Bong Sook Jhun, Shey-Shing Sheu, Jin O-Uchi
BIOPHYSICAL JOURNAL
(2018)
Article
Neurosciences
Bong Sook Jhun, Jin O-Uchi, Stephanie M. Adaniya, Thomas J. Mancini, Jessica L. Cao, Michelle E. King, Amy K. Landi, Hanley Ma, Milla Shin, Donqin Yang, Xiaole Xu, Yisang Yoon, Gaurav Choudhary, Richard T. Clements, Ulrike Mende, Shey-Shing Sheu
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Review
Neurosciences
Pei Wang, Celia Fernandez-Sanz, Wang Wang, Shey-Shing Sheu
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Cell Biology
Sergio De La Fuente, Jonathan P. Lambert, Zuzana Nichtova, Celia Fernandez Sanz, John W. Elrod, Shey-Shing Sheu, Gyorgy Csordas
Article
Cell Biology
Barbara A. Miller, JuFang Wang, Jianliang Song, Xue-Qian Zhang, Iwona Hirschler-Laszkiewicz, Santhanam Shanmughapriya, Dhanendra Tomar, Sudasan Rajan, Arthur M. Feldman, Muniswamy Madesh, Shey-Shing Sheu, Joseph Y. Cheung
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Sergio De la Fuente, Shey-Shing Sheu
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
Stephen Hurst, Ariele Baggett, Gyorgy Csordas, Shey-Shing Sheu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Hakjoo Lee, Sylvia B. Smith, Shey-Shing Sheu, Yisang Yoon
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Review
Neurosciences
Marilen Federico, Sergio De la Fuente, Julieta Palomeque, Shey-Shing Sheu
Summary: Metabolic diseases are a series of pathologies characterized by abnormal body glucose usage, including metabolic syndrome, prediabetes, and diabetes mellitus types 1 and 2. These chronic diseases cause metabolic disturbances and are classified as multi-organ diseases. Mitochondria play a key role in the heart dysfunction caused by metabolic diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Cell Biology
Pierre Eyenga, Benjamin Rey, Lilia Eyenga, Shey-Shing Sheu
Summary: The link between liver dysfunction and decreased mitochondrial oxidative phosphorylation in sepsis has been established. The efficiency of mitochondrial coupling collapses in the early stage but is expected to increase during recovery phases. Slipping reactions at the cytochrome oxidase and ATP synthase appear to be a determining element in regulating coupling efficiency.
Review
Biochemistry & Molecular Biology
Paolo Bernardi, Christoph Gerle, Andrew P. Halestrap, Elizabeth A. Jonas, Jason Karch, Nelli Mnatsakanyan, Evgeny Pavlov, Shey-Shing Sheu, Alexander A. Soukas
Summary: The mitochondrial permeability transition (mPT) is a Ca2+-dependent and cyclophilin D (CypD)-facilitated increase in inner mitochondrial membrane permeability. It is mediated by the mitochondrial permeability transition pore (mPTP), which allows diffusion of molecules up to 1.5 kDa in size. Sustained mPTP opening leads to mitochondrial swelling and cell death, while transient mPTP opening can have physiological roles such as changes in mitochondrial bioenergetics and Ca2+ efflux.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Critical Care Medicine
Pierre Eyenga, Damien Roussel, Jerome Morel, Benjamin Rey, Caroline Romestaing, Virginie Gueguen-Chaignon, Shey-Shing Sheu, Jean Paul Viale
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Jin O-Uchi, Bong Sook Jhun, Shey-Shing Sheu
Meeting Abstract
Biochemistry & Molecular Biology
Jessica L. Cao, Stephanie M. Adaniya, Dongqin Yang, Michelle E. King, Bong Sook Jhun, Ulrike Mende, Shey-Shing Sheu, Jin O-Uchi
Meeting Abstract
Biophysics
Marina Balycheva, Stephen Hurst, Jyotsna Mishra, Gyorgy Csordas, Shey-Shing Sheu
BIOPHYSICAL JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)