Water Mediated Ligand Functional Group Cooperativity: The Contribution of a Methyl Group to Binding Affinity is Enhanced by a COO– Group Through Changes in the Structure and Thermodynamics of the Hydration Waters of Ligand–Thermolysin Complexes

Title
Water Mediated Ligand Functional Group Cooperativity: The Contribution of a Methyl Group to Binding Affinity is Enhanced by a COO– Group Through Changes in the Structure and Thermodynamics of the Hydration Waters of Ligand–Thermolysin Complexes
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 19, Pages 8283-8302
Publisher
American Chemical Society (ACS)
Online
2012-08-16
DOI
10.1021/jm300472k

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