Water Mediated Ligand Functional Group Cooperativity: The Contribution of a Methyl Group to Binding Affinity is Enhanced by a COO– Group Through Changes in the Structure and Thermodynamics of the Hydration Waters of Ligand–Thermolysin Complexes

标题
Water Mediated Ligand Functional Group Cooperativity: The Contribution of a Methyl Group to Binding Affinity is Enhanced by a COO– Group Through Changes in the Structure and Thermodynamics of the Hydration Waters of Ligand–Thermolysin Complexes
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 19, Pages 8283-8302
出版商
American Chemical Society (ACS)
发表日期
2012-08-16
DOI
10.1021/jm300472k

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