Inflammation and its genesis in cystic fibrosis

Role of Exchange Protein Activated by cAMP 1 in Regulating Rates of Microtubule Formation in Cystic Fibrosis Epithelial Cells

(2015) Sharon M. Rymut et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Quantitative Proteomics Reveals an Altered Cystic FibrosisIn VitroBronchial Epithelial Secretome

(2015) Jennifer R. Peters-Hall et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Antimicrobial activity of ibuprofen: New perspectives on an “Old” non-antibiotic drug

(2015) Jelena Obad et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis

(2014) Steven M. Rowe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

(2014) K. Pohl et al.   BLOOD

Invariant Natural Killer T (iNKT) Cells Prevent Autoimmunity, but Induce Pulmonary Inflammation in Cystic Fibrosis

(2014) Nanna Siegmann et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oxidation contributes to low glutathione in the airways of children with cystic fibrosis

(2014) A. J. Kettle et al.   EUROPEAN RESPIRATORY JOURNAL

Differential expression of IL-33 and HMGB1 in the lungs of stable cystic fibrosis patients

(2014) K. Tiringer et al.   EUROPEAN RESPIRATORY JOURNAL

Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis

(2014) F. C. Ringholz et al.   EUROPEAN RESPIRATORY JOURNAL

Comparison of the Effects of Aerobic Conditioning Before and After Pulmonary Allergic Inflammation

(2014) Ronaldo Aparecido da Silva et al.   INFLAMMATION

Redox balance in Cystic Fibrosis

(2014) Assem G. Ziady et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate Pseudomonas aeruginosa biofilms growing on cystic fibrosis airway epithelial cells

(2014) S. Moreau-Marquis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Aerobic exercise attenuates pulmonary inflammation induced by Streptococcus pneumoniae

(2014) Clarice R. Olivo et al.   JOURNAL OF APPLIED PHYSIOLOGY

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine

(2014) G. Liu et al.   JOURNAL OF IMMUNOLOGY

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation

(2014) A. Gaggar et al.   JOURNAL OF IMMUNOLOGY

Immunomodulatory Effects of a Low-Dose Clarithromycin-Based Macrolide Solution Pressurised Metered Dose Inhaler

(2014) Mehra Haghi et al.   PHARMACEUTICAL RESEARCH

T Helper Cell Subsets Specific for Pseudomonas aeruginosa in Healthy Individuals and Patients with Cystic Fibrosis

(2014) Hannah K. Bayes et al.   PLoS One

Quality of life is associated with physical activity and fitness in cystic fibrosis

(2014) Helge Hebestreit et al.   BMC Pulmonary Medicine

Reduced microtubule acetylation in cystic fibrosis epithelial cells

(2013) Sharon M. Rymut et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Th17- and Th2-skewed Cytokine Profile in Cystic Fibrosis Lungs Represents a Potential Risk Factor forPseudomonas aeruginosaInfection

(2013) Kerstin Tiringer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung Phenotype of Juvenile and Adult Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferrets

(2013) Xingshen Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Native Small Airways Secrete Bicarbonate

(2013) A. K. M. Shamsuddin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nebulized thiocyanate improves lung infection outcomes in mice

(2013) J D Chandler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

(2013) Lutz Nährlich et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Selective Metabolism of Hypothiocyanous Acid by Mammalian Thioredoxin Reductase Promotes Lung Innate Immunity and Antioxidant Defense

(2013) Joshua D. Chandler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of supervised training on FEV1 in cystic fibrosis: A randomised controlled trial

(2013) Susi Kriemler et al.   Journal of Cystic Fibrosis

Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4via PI3K/Akt Pathway in LPS-Induced Acute Lung Injury

(2013) Yi Yang et al.   MEDIATORS OF INFLAMMATION

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Long-Term Voluntary Exercise Wheel Running on Susceptibility to Bacterial Pulmonary Infections in a Mouse Model

(2013) Pauline B. van de Weert – van Leeuwen et al.   PLoS One

Chronic inflammation and infection associate with a lower exercise training response in cystic fibrosis adolescents

(2013) Pauline B. van de Weert-van Leeuwen et al.   RESPIRATORY MEDICINE

IL-17 in lung disease: friend or foe?

(2013) Hui-Leng Tan et al.   THORAX

Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells

(2012) Assem G. Ziady et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neutrophil Elastase Degrades Cystic Fibrosis Transmembrane Conductance Regulator via Calpains and Disables Channel FunctionIn VitroandIn Vivo

(2012) Mathieu Le Gars et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

THIOCYANATE: A potentially useful therapeutic agent with host defense and antioxidant properties

(2012) Joshua D. Chandler et al.   BIOCHEMICAL PHARMACOLOGY

Effect of Azithromycin on Systemic Markers of Inflammation in Patients With Cystic Fibrosis Uninfected With Pseudomonas aeruginosa

(2012) Felix Ratjen et al.   CHEST

IL-33 is expressed in epithelia from patients with cystic fibrosis and potentiates neutrophil recruitment

(2012) Lucie Roussel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory role of β-arrestin-2 in cholesterol processing in cystic fibrosis epithelial cells

(2012) Mary E. Manson et al.   JOURNAL OF LIPID RESEARCH

MMP-9 Cleaves SP-D and Abrogates Its Innate Immune Functions In Vitro

(2012) Preston E. Bratcher et al.   PLoS One

Doxycycline exhibits anti-inflammatory activity in CF bronchial epithelial cells

(2012) Timothy J. Bensman et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Serial Analysis of the Gut and Respiratory Microbiome in Cystic Fibrosis in Infancy: Interaction between Intestinal and Respiratory Tracts and Impact of Nutritional Exposures

(2012) J. C. Madan et al.   mBio

Infection, Inflammation, and Lung Function Decline in Infants with Cystic Fibrosis

(2011) Naveen Pillarisetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Th17 Pathway in Cystic Fibrosis Lung Disease

(2011) Hui-Leng Tan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nebulized Hypertonic Saline Decreases IL-8 in Sputum of Patients with Cystic Fibrosis

(2011) Emer P. Reeves et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Induction of Type I Interferon Signaling byPseudomonas aeruginosaIs Diminished in Cystic Fibrosis Epithelial Cells

(2011) Dane Parker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chronic infection and inflammation affect exercise capacity in cystic fibrosis

(2011) P.B. van de Weert-van Leeuwen et al.   EUROPEAN RESPIRATORY JOURNAL

The role of matrix metalloproteinases in cystic fibrosis lung disease

(2011) A. Gaggar et al.   EUROPEAN RESPIRATORY JOURNAL

Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions

(2011) Daniel Lorentzen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic Fibrosis

(2011) E. M. Bruscia et al.   JOURNAL OF IMMUNOLOGY

The BASES Expert Statement on Exercise, Immunity, and Infection

(2011) Michael Gleeson et al.   JOURNAL OF SPORTS SCIENCES

Dysfunctional CFTR Alters the Bactericidal Activity of Human Macrophages against Pseudomonas aeruginosa

(2011) Paola Del Porto et al.   PLoS One

Defective CFTR Expression and Function Are Detectable in Blood Monocytes: Development of a New Blood Test for Cystic Fibrosis

(2011) Claudio Sorio et al.   PLoS One

Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome

(2011) A. L. Radtke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children

(2010) David K. Meyerholz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lack of Cystic Fibrosis Transmembrane Conductance Regulator in CD3+Lymphocytes Leads to Aberrant Cytokine Secretion and Hyperinflammatory Adaptive Immune Responses

(2010) Christian Mueller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death

(2010) Katrin Anne Becker et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma

(2010) L. Schmitt et al.   EUROPEAN RESPIRATORY JOURNAL

Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Enhances Activation of p38 and ERK MAPKs, Increasing Interleukin-6 Synthesis in Airway Epithelial Cells Exposed toPseudomonas aeruginosa

(2010) Julie Bérubé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary Proteases in the Cystic Fibrosis Lung Induce Interleukin 8 Expression from Bronchial Epithelial Cells via a Heme/Meprin/Epidermal Growth Factor Receptor/Toll-like Receptor Pathway

(2010) Sonya Cosgrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

(2010) Sandra Moriceau et al.   Journal of Innate Immunity

CFTR-mediated halide transport in phagosomes of human neutrophils

(2010) Richard G. Painter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis

(2010) Elena Bravo et al.   Lipids in Health and Disease

Airway Microbiota and Pathogen Abundance in Age-Stratified Cystic Fibrosis Patients

(2010) Michael J. Cox et al.   PLoS One

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

(2010) R. J. Snelgrove et al.   SCIENCE

The Development of Lung Disease in Cystic Fibrosis Pigs

(2010) J. J. Wine   Science Translational Medicine

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

(2010) D. A. Stoltz et al.   Science Translational Medicine

Airway remodelling and its relationship to inflammation in cystic fibrosis

(2010) N. Regamey et al.   THORAX

The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease

(2009) David P. Nichols et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells

(2009) Toni R. Bartling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening

(2009) Peter D. Sly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Azithromycin Reduces Exaggerated Cytokine Production by M1 Alveolar Macrophages in Cystic Fibrosis

(2009) Magali Meyer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IL-17 primes airway epithelial cells lacking functional Cystic Fibrosis Transmembrane conductance Regulator (CFTR) to increase NOD1 responses

(2009) Lucie Roussel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipid metabolism in cystic fibrosis

(2009) Tilla S Worgall   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis

(2009) S. Brennan et al.   EUROPEAN RESPIRATORY JOURNAL

Long-term effects of a partially supervised conditioning programme in cystic fibrosis

(2009) H. Hebestreit et al.   EUROPEAN RESPIRATORY JOURNAL

Disease-causing Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Determine the Functional Responses of Alveolar Macrophages

(2009) Ludmila V. Deriy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation

(2009) S. Weldon et al.   JOURNAL OF IMMUNOLOGY

EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity

(2009) Rebecca Darrah et al.   PHYSIOLOGICAL GENOMICS

Azithromycin Treatment Alters Gene Expression in Inflammatory, Lipid Metabolism, and Cell Cycle Pathways in Well-Differentiated Human Airway Epithelia

(2009) Carla Maria P. Ribeiro et al.   PLoS One

The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases

(2009) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Airway Smooth Muscle Mass in Children with Asthma, Cystic Fibrosis, and Non-Cystic Fibrosis Bronchiectasis

(2008) Nicolas Regamey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

(2008) Steven M. Rowe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/−Mice

(2008) Emanuela M. Bruscia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of the Cystic Fibrosis Transmembrane Conductance Channel in Human Airway Smooth Muscle

(2008) Marie-Claire Michoud et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oxidative Stress CausesIL8Promoter Hyperacetylation in Cystic Fibrosis Airway Cell Models

(2008) Toni R. Bartling et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide

(2008) Claudine Guilbault et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lipoxin A4 and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy

(2008) Raphaël Chiron et al.   Journal of Cystic Fibrosis

The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils

(2008) R. G. Painter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Health-related fitness and trainability in children with cystic fibrosis

(2008) W. Gruber et al.   PEDIATRIC PULMONOLOGY

Dysfunction of Nrf-2 in CF Epithelia Leads to Excess Intracellular H2O2 and Inflammatory Cytokine Production

(2008) Junnan Chen et al.   PLoS One

Fenretinide Corrects Newly Found Ceramide Deficiency in Cystic Fibrosis

(2007) Claudine Guilbault et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY