Article
Critical Care Medicine
Anoopindar K. Bhalla, Margaret J. Klein, Guillaume Emeriaud, Yolanda M. Lopez-Fernandez, Natalie Napolitano, Analia Fernandez, Awni M. Al-Subu, Rainer Gedeit, Steven L. Shein, Ryan Nofziger, Deyin Doreen Hsing, George Briassoulis, Stavroula Ilia, Florent Baudin, Byron Enrique Pineres-Olave, Ledys Maria Izquierdo, John C. Lin, Ira M. Cheifetz, Martin C. J. Kneyber, Lincoln Smith, Robinder G. Khemani, Christopher J. L. Newth
Summary: The study described mechanical ventilation management in pediatric acute respiratory distress syndrome and found that nonadherence to lung-protective ventilation principles is common, potentially impacting outcomes. Modifiable factors exist that may improve adherence.
CRITICAL CARE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nanoscience & Nanotechnology
Shuai Bian, Hongfei Cai, Youbin Cui, Wanguo Liu, Chunsheng Xiao
Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Zhuoran Xiao, Song Hu, Wenting Xu, Sheng Wang, Wei Mo, Huimin Deng, Juan Wei, Hao Yang, Wenyu Zhou, Quanfu Li, Huanping Zhou, Xin Lv
Summary: This bibliometric analysis reveals a rapid growth trend of NLRP3 inflammasome in ALI/ARDS. China is the largest contributor, while the USA offers the most landmark papers. The major disciplines of research front have shifted from Medicine, Medical, Clinical to Molecular, Biology, Immunology. In recent years, studies on the role of NLRP3 in COVID-19-associated ALI/ARDS and oxidative stress have become hotspots.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Laetitia Pouzol, Anna Sassi, Nadege Baumlin, Melanie Tunis, Daniel S. Strasser, Francois Lehembre, Marianne M. Martinic
Summary: The loss of control in immune cell trafficking to inflamed lung tissue leads to ALI/ARDS. The paper investigates the pathological role of the CXCR3/CXCR4/CXCR7 axis in a murine model of ALI. The study suggests the clinical potential of the CXCR7 antagonist, ACT-1004-1239, in reducing inflammation and improving lung function in ALI/ARDS.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Chang Liu, Kun Xiao, Lixin Xie
Summary: This review discusses the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and the biological characteristics and mechanisms of mesenchymal stromal cells (MSCs) in the treatment of ALI/ARDS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Critical Care Medicine
Haruka Hashimoto, Takeshi Yoshida, Andi Muhammad Fadlillah Firstiogusran, Hiroki Taenaka, Ryota Nukiwa, Yukiko Koyama, Akinori Uchiyama, Yuji Fujino
Summary: Patient-ventilator asynchrony during mechanical ventilation may lead to lung and diaphragm injury. Breath stacking has a more detrimental effect on oxygenation, lung compliance, and lung injury compared to assist control, while reverse triggering predominantly causes diaphragm injury. Therefore, careful monitoring and management of patient-ventilator asynchrony is crucial in minimizing lung and diaphragm injury in ARDS patients.
CRITICAL CARE MEDICINE
(2023)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yu-Qiong He, Can-Can Zhou, Lu-Yao Yu, Liang Wang, Jiu-Ling Deng, Yu-Long Tao, Feng Zhang, Wan-Sheng Chen
Summary: ALI and ARDS are common life-threatening lung diseases with high mortality rates, but there is still a lack of effective pharmacological therapies. Developing new drugs for therapy of ALI/ARDS is in great demand, as natural compounds have shown potential therapeutic effects and may also be helpful for treatment of COVID-19.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Covadonga Huidobro, Paula Martin-Vicente, Cecilia Lopez-Martinez, Ines Alonso-Lopez, Laura Amado-Rodriguez, Irene Crespo, Guillermo M. Albaiceta
Summary: Acute lung injury can lead to respiratory failure and death, with current treatment relying on supportive measures and mechanical ventilation. Research has focused on molecular and cellular pathways to find new approaches to prevent and treat this condition, with cellular senescence being a potential factor.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Critical Care Medicine
Nadir Yehya, Lincoln J. Smith, Neal J. M. Thomas, Katherine M. Steffen, Jerry Zimmerman, Jan Hau J. Lee, Simon J. L. Erickson, Steven L. Shein
Summary: This article presents the revisions of the definitions for Pediatric Acute Respiratory Distress Syndrome (PARDS) made during the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2). Through the assessment of a large number of research data, 17 consensus-based definition statements were generated to update the definitions of PARDS, Possible PARDS, and At-Risk for PARDS.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alexis White, Zhengke Wang, Xing Wang, Michelle King, Cynthia Guo, Chris Mantsounga, Alfred Ayala, Alan R. Morrison, Gaurav Choudhary, Frank Sellke, Eboni Chambers, Lorraine B. Ware, Sharon Rounds, Qing Lu
Summary: Cigarette smoke exposure increases the incidence and severity of acute respiratory distress syndrome (ARDS), but the mechanisms are unclear. This study found that cigarette smoke impairs mitophagy flux and exacerbates mitochondrial damage and NLRP3 inflammasome activation, leading to increased acute lung injury. Inhibition of inflammasome or downstream component IL-1 beta attenuates the cigarette smoke-induced lung injury.
Article
Medicine, Research & Experimental
Ke Wang, Youyu Wang, Yufang Cao, Hao Wang, Yongfang Zhou, Lijuan Gao, Zijian Zeng, Mengxin Cheng, Xiaodong Jin, Jun Chen, Fuqiang Wen, Tao Wang
Summary: This study found that lumican is increased in the early phase of acute respiratory distress syndrome (ARDS), and is associated with disease severity and inflammatory fibrotic processes. Lumican promotes fibrotic responses in ARDS by triggering the transdifferentiation of lung fibroblasts into myofibroblasts and epithelial-mesenchymal transition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Critical Care Medicine
Jocelyn K. Grunwell, Mary Dahmer, Anil W. Sapru, Michael Quasney, Heidi Flori
Summary: This article reviews studies on the pathobiology, severity, and risk stratification of pediatric acute respiratory distress syndrome (PARDS) in children, aiming to guide current medical practice and identify important areas for future research. A comprehensive literature search was conducted, and relevant evidence was summarized and used to develop clinical recommendations. The findings include one clinical recommendation and six research statements related to risk stratification and characterization of PARDS severity.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Health Care Sciences & Services
Markita Suttle, Mark W. Hall, Murray M. Pollack, Robert A. Berg, Patrick S. McQuillen, Peter M. Mourani, Anil Sapru, Joseph A. Carcillo, Emily Startup, Richard Holubkov, J. Michael Dean, Daniel A. Notterman, Kathleen L. Meert
Summary: Mental health symptoms show improvement among parents during the first 13 months after their child's death, but persist for some. Black parents and families with sudden unexpected death of a child may be at higher risk for poor adjustment during bereavement.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2022)
Article
Pediatrics
Cal Robinson, Erin Hessey, Sophia Nunes, Marc Dorais, Rahul Chanchlani, Jacques Lacroix, Philippe Jouvet, Veronique Phan, Michael Zappitelli
Summary: This study found that nephrology follow-up after pediatric AKI was uncommon, but nearly all survivors received follow-up from non-nephrologist physicians within one year post discharge. This suggests that knowledge translation strategies for AKI follow-up should be targeted at non-nephrology healthcare providers.
PEDIATRIC RESEARCH
(2022)
Article
Critical Care Medicine
Michelle J. Lim, Matt S. Zinter, Lucia Chen, Kayley Man Yee Wong, Anoopindar Bhalla, Kinisha Gala, Mona Guglielmo, Mustafa Alkhouli, Leanna L. Huard, Mark R. Hanudel, Sitaram Vangala, Andreas Schwingshackl, Michael Matthay, Anil Sapru
Summary: This study investigates the relationship between plasma soluble receptor for advanced glycation end products (sRAGE) and primary pulmonary dysfunction, extrapulmonary organ dysfunction, and mortality in pediatric acute respiratory distress syndrome (ARDS) patients. The results show that sRAGE is associated with extrapulmonary organ dysfunction and markers of inflammation in ARDS patients, and is also related to mortality in children with indirect lung injury.
CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Markita Suttle, Mark W. Hall, Murray M. Pollack, Robert A. Berg, Patrick S. McQuillen, Peter M. Mourani, Anil Sapru, Joseph A. Carcillo, Emily Startup, Richard Holubkov, Daniel A. Notterman, Gillian Colville, Kathleen L. Meert
Summary: In the first 13 months after a child's death in the PICU, parents bereaved perceive a moderate level of post-traumatic growth, with wide variability. Education level and complicated grief symptoms may influence how parents perceive post-traumatic growth.
JOURNAL OF PALLIATIVE MEDICINE
(2022)
Article
Critical Care Medicine
Francois Proulx, Guillaume Emeriaud, Tine Francois, Jean-Sebastien Joyal, Nicolas Nardi, Atsushi Kawaguchi, Philippe Jouvet, Michael Sauthier
Summary: The study found that mortality after severe pediatric acute respiratory distress syndrome is associated with the severity of organ dysfunction, hypoxemia metrics, and pulmonary metrics.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Robert M. Sutton, Heather A. Wolfe, Ron W. Reeder, Tageldin Ahmed, Robert Bishop, Matthew Bochkoris, Candice Burns, J. Wesley Diddle, Myke Federman, Richard Fernandez, Deborah Franzon, Aisha H. Frazier, Stuart H. Friess, Kathryn Graham, David Hehir, Christopher M. Horvat, Leanna L. Huard, William P. Landis, Tensing Maa, Arushi Manga, Ryan W. Morgan, Vinay M. Nadkarni, Maryam Y. Naim, Chella A. Palmer, Carleen Schneiter, Matthew P. Sharron, Ashley Siems, Neeraj Srivastava, Sarah Tabbutt, Bradley Tilford, Shirley Viteri, Robert A. Berg, Michael J. Bell, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, Ericka L. Fink, Mark Hall, Patrick S. McQuillen, Kathleen L. Meert, Peter M. Mourani, Daniel Notterman, Murray M. Pollack, Anil Sapru, David Wessel, Andrew R. Yates, Athena F. Zuppa
Summary: A bundled intervention of cardiopulmonary resuscitation training and physiologically focused structured debriefing did not significantly improve patient survival with favorable neurologic outcome in pediatric patients who experienced cardiac arrest in the ICU compared to usual care.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Critical Care Medicine
Andrew R. Yates, John T. Berger, Ron W. Reeder, Russell Banks, Peter M. Mourani, Robert A. Berg, Joseph A. Carcillo, Todd Carpenter, Mark W. Hall, Kathleen L. Meert, Patrick S. McQuillen, Murray M. Pollack, Anil Sapru, Daniel A. Notterman, Richard Holubkov, J. Michael Dean, David L. Wessel
Summary: This study characterizes the use of inhaled nitric oxide (iNO) in pediatric cardiac patients and investigates the relationship between patient characteristics before iNO initiation and outcomes following cardiac surgery. The study found that pediatric patients who received iNO treatment for cardiac indications had a high mortality rate and significant morbidity. Right ventricular dysfunction was associated with mortality and the need for ventilator support, while pulmonary hypertension was not associated with these outcomes.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Guillaume Emeriaud, Yolanda Lopez-Fernandez, Narayan Prabhu Iyer, Melania M. Bembea, Asya Agulnik, Ryan P. Barbaro, Florent Baudin, Anoopindar Bhalla, Werther Brunow de Carvalho, Christopher L. Carroll, Ira M. Cheifetz, Mohammod J. Chisti, Pablo Cruces, Martha A. Q. Curley, Mary K. Dahmer, Heidi J. Dalton, Simon J. Erickson, Sandrine Essouri, Analia Fernandez, Heidi R. Flori, Jocelyn R. Grunwell, Philippe Jouvet, Elizabeth Y. Killien, Martin C. J. Kneyber, Sapna R. Kudchadkar, Steven Kwasi Korang, Jan Hau Lee, Duncan J. Macrae, Aline Maddux, Vicent M. Alapont, Brenda M. Morrow, Vinay M. Nadkarni, Natalie Napolitano, Christopher J. L. Newth, Marti Pons-Odena, Michael W. Quasney, Prakadeshwari Rajapreyar, Jerome Rambaud, Adrienne G. Randolph, Peter Rimensberger, Courtney M. Rowan, L. Nelson Sanchez-Pinto, Anil Sapru, Michael Sauthier, Steve L. Shein, Lincoln S. Smith, Katerine Steffen, Muneyuki Takeuchi, Neal J. Thomas, Sze Man Tse, Stacey Valentine, Shan Ward, R. Scott Watson, Nadir Yehya, Jerry J. Zimmerman, Robinder G. Khemani
Summary: This study is an international consensus conference aiming to update the guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and previously unaddressed topics. The study involved 11 subgroups addressing 11 topic areas, resulting in 146 recommendations and statements that will facilitate the implementation and adherence to the best clinical practice.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Editorial Material
Pediatrics
Cecilia Rotava Buratti, Philippe Jouvet
Summary: This study provides a classification method for the severity of Multisystem Inflammatory Syndrome in Children (MIS-C) through the MIS-C severity score (MSS), and identifies a combination of seven variables that can stratify the severity. It serves as a foundation for future research.
PEDIATRIC RESEARCH
(2023)
Article
Engineering, Biomedical
Lise Boudreault, Maxence Hebert-Lavoie, Karine Ung, Celia Mahmoudhi, Quynh Phuong Vu, Philippe Jouvet, Philippe Doyon-Poulin
Summary: In a pediatric intensive care unit, a large-screen dashboard was implemented to manage resources and replace handwritten whiteboard information. However, during the COVID-19 pandemic, the dashboard showed limitations in providing situational awareness for resource management and decision-making. Through goal-oriented interviews with clinicians, a situational awareness-oriented dashboard with 22 key indicators was designed. A usability evaluation compared the new dashboard to the previous one, resulting in five improvements and five limitations.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Article
Engineering, Biomedical
Thanh-Dung Le, Rita Noumeir, Jerome Rambaud, Guillaume Sans, Philippe Jouvet
Summary: Recent studies have shown that a well-tuned multilayer perceptron performs better than other generative classifiers, including deep learning models, in clinical text classification on small datasets. Feature selection can effectively enhance the performance of the neural network classifier, but most methods only consider linear dependencies between variables and ignore the sparsity of the feature space. This study proposes an autoencoder learning algorithm to compress the sparse clinical note representation feature space and demonstrates its effectiveness.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Article
Chemistry, Analytical
Vincent Boivin, Mana Shahriari, Gaspar Faure, Simon Mellul, Edem Donatien Tiassou, Philippe Jouvet, Rita Noumeir
Summary: This study aimed to develop a standardized model for automated assessment of vital distress in critically ill children in a pediatric intensive care unit (PICU). A high-quality video database was constructed by automatically acquiring videos through a secure web application. The database includes RGB, thermographic, and point cloud videos and is linked to the patient's electronic medical health record and high-resolution medical database.
Article
Medicine, General & Internal
Mohammad Yahyatabar, Philippe Jouvet, Donatien Fily, Jerome Rambaud, Michael Levy, Robinder G. Khemani, Farida Cheriet
Summary: Acute respiratory distress syndrome (ARDS), including severe pulmonary COVID infection, has a high mortality rate. Early detection is crucial to avoid complications in treatment. This paper presents a web-based platform that utilizes artificial intelligence to automatically assess pediatric ARDS using chest X-ray images. The platform achieves a recall rate of 95.25% and a precision of 88.02%, making it a valuable tool in diagnosing ARDS.
Article
Engineering, Biomedical
Thanh-Dung Le, Rita Noumeir, Jerome Rambaud, Guillaume Sans, Philippe Jouvet
Summary: The rapid progress in clinical data management systems and artificial intelligence approaches has enabled the era of personalized medicine. Intensive care units (ICUs) are ideal environments for developing such systems due to their collection of rich clinical data and high level of computerization. A retrospective clinical study was designed using clinical natural language to aid in early diagnosis of heart failure in critically ill children, showing promising results with a neural network achieving 89% accuracy. Further research is needed to apply this methodology in other languages and institutions.
IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Monisha Shcherbakova, Rita Noumeir, Michael Levy, Armelle Bridier, Victor Lestrade, Philippe Jouvet
Summary: This study explored the use of infrared thermography to analyze temperature profiles of critically ill children. It found that thermography was effective in estimating body temperature and showed a correlation with specific clinical conditions.
IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY
(2022)