☆ 4.6 Editorial Material

microRNAs: small regulators with a big impact on lipid metabolism

JOURNAL OF LIPID RESEARCH (2013)

Journal

JOURNAL OF LIPID RESEARCH

Volume 54, Issue 5, Pages 1159-1160

Publisher

ELSEVIER

DOI: 10.1194/jlr.E036954

Keywords

-

Categories

Biochemistry & Molecular Biology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Review Neurosciences

MicroRNAs - small RNAs with a big influence on brain excitability

Gareth Morris

Summary: MicroRNAs are short non-coding RNAs that regulate gene expression by targeting complementary sequences in mRNA transcripts, primarily in the 3' untranslated region. They play a role in modulating neural excitability and different processes in the nervous system. Additionally, the expression of microRNAs is regulated by neuronal activity, forming feedback loops.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

Add to Collection

Review Cell Biology

MicroRNAs: Small molecules with big impacts in liver injury

Alyaa S. Abdel Halim, Hassan Ahmed Rudayni, Anis Ahmad Chaudhary, Mohamed A. M. Ali

Summary: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression posttranscriptionally by binding to specific messenger RNA targets. They play a significant role in various physiological processes in the liver, such as differentiation, proliferation, and apoptosis, as well as liver pathology. Extracellular vesicles like exosomes, which contain secreted miRNAs, facilitate communication between tissues by altering gene expression and function of distant cells. MiRNAs in body fluids can be used as noninvasive biomarkers to detect liver abnormalities early and evaluate liver pathological states. Altered miRNA expression is associated with deregulation of liver metabolism, liver damage, fibrosis, and tumor formation, making them attractive therapeutic targets for liver diseases.

JOURNAL OF CELLULAR PHYSIOLOGY (2023)

Add to Collection

Review Health Care Sciences & Services

MicroRNAs as Regulators of Cancer Cell Energy Metabolism

Natarajaseenivasan Suriya Muthukumaran, Prema Velusamy, Charles Solomon Akino Mercy, Dianne Langford, Kalimuthusamy Natarajaseenivasan, Santhanam Shanmughapriya

Summary: Cancer cells rapidly reprogram their metabolism to adapt to the tumor environment or escape chemotherapy. Recent studies have shown that cancer cells rely on glutamine, lipid, and mitochondrial metabolism for energy. Some miRNAs play a key role in regulating these metabolic changes. Additionally, miRNAs can regulate mitochondrial calcium stores and energy metabolism, promoting cancer cell survival, growth, and metastasis.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Add to Collection

Review Cardiac & Cardiovascular Systems

Roles of MicroRNAs in Glucose and Lipid Metabolism in the Heart

Hengzhi Du, Yanru Zhao, Huaping Li, Dao Wen Wang, Chen Chen

Summary: miRNAs play a crucial role in heart development and pathological processes, regulating cardiovascular processes and nutrient metabolism. Maintaining cardiac glucose and lipid metabolism balance may benefit patients with cardiovascular diseases.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Add to Collection

Article Medicine, General & Internal

Small vulnerable newborns-big potential for impact

Per Ashorn, Ulla Ashorn, Yvonne Muthiani, Samira Aboubaker, Sufia Askari, Rajiv Bahl, Robert E. Black, Nita Dalmiya, Christopher P. Duggan, G. Justus Hofmeyr, Stephen H. Kennedy, Nigel Klein, Joy E. Lawn, Jeremy Shiffman, Jonathon Simon, Marleen Temmerman

Summary: Despite progress in child survival, neonatal mortality remains high in some countries. Most neonatal deaths are caused by preterm birth, small for gestational age, or low birthweight. These conditions have short-term and long-term consequences and impact human capital. However, progress in preventing these issues has been slow due to lack of consensus and a suitable governance structure. A new definition and framework, called the small vulnerable newborn (SVN), is proposed to improve problem definition and prevention strategies. Interventions targeting SVN prevention would benefit live-born infants, reduce stillbirths, improve maternal health, and contribute to social and economic development.

LANCET (2023)

Add to Collection

Review Oncology

MicroRNAs as regulators of tumor metabolism

Francesca Ruggieri, Katharina Jonas, Manuela Ferracin, Michael Dengler, Vanessa Jager, Martin Pichler

Summary: Cancer cells reprogram their metabolism to support growth, including alterations in lactate, glutamine, and lipid metabolism. MicroRNAs, a class of non-coding RNAs, play important roles in regulating biological pathways and their altered expression has been linked to various diseases, including cancer. Tumor suppressor microRNAs involved in tumor metabolism are frequently downregulated and can serve as biomarkers and potential therapeutic targets. This review summarizes recent findings on the role of microRNAs in regulating tumor metabolism.

ENDOCRINE-RELATED CANCER (2023)

Add to Collection

Review Food Science & Technology

Recent insights into the molecular regulators and mechanisms of taurine to modulate lipid metabolism: a review

Arya K. P. Devi, Asha Martin

Summary: Lipid metabolism disorders are serious public health issues, and taurine has been found to regulate lipid metabolism through various physiological effects. However, the mechanisms underlying the lipid-lowering action of taurine remain unclear. This review focuses on the role of taurine in lipid metabolism and discusses taurine-related interventions for combating lipid disorders.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Add to Collection

Article Plant Sciences

Dynamic RNA-Seq Study Reveals the Potential Regulators of Seed Germination in Paris polyphylla var. yunnanensis

Zhengbin Tang, Jia Zhao, Bin Yang, Shan Sun, Furong Xu, Zhoufei Wang

Summary: In this study, RNA sequencing was used to analyze the differentially expressed genes (DEGs) during seed germination of Paris polyphylla var. yunnanensis. Several genes potentially involved in seed germination were identified, providing a valuable resource for further studying the molecular basis of seed germination in this medicinal plant.

PLANTS-BASEL (2022)

Add to Collection

Review Chemistry, Medicinal

In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism

Valery M. Dembitsky

Summary: This review focuses on a rare group of steroids and triterpenoids with common properties as regulators of lipid metabolism. The compounds are divided based on chemical structure and exhibit various biological activities, such as regulating cholesterol metabolism and treating diseases. The studies indicate potential pharmacological properties of these compounds in various biological processes.

MARINE DRUGS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

microRNAs: Small molecules with a large impact on colorectal cancer

Sahand Moazzendizaji, Andrey Sevbitov, Fatemeh Ezzatifar, Hamid Reza Jalili, Morteza Aalii, Maryam Hemmatzadeh, Saeed Aslani, Jamshid Gholizadeh Navashenaq, Roghaiyeh Safari, Ramin Hosseinzadeh, Mohammad Reza Rahmany, Hamed Mohammadi

Summary: Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity worldwide. Aberrant transcription of microRNAs (miRNAs) plays a significant role in the development of CRC, affecting prognosis, diagnosis, and treatment outcomes. MiRNAs are involved in various signaling pathways, primarily p53, EGFR, Wnt, and TGF-beta pathways.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Triclosan down-regulates fatty acid synthase through microRNAs in HepG2 cells

Donglei Sun, Tianhe Zhao, Keyan Long, Mei Wu, Zunzhen Zhang

Summary: Triclosan downregulates FASN expression through upregulating miRNAs, leading to inhibition of lipid metabolism and cell growth in human hepatoma cells via apoptosis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Add to Collection

Review Oncology

Long non-coding RNAs: Key regulators involved in metabolic reprogramming in cancer

Chunxia Liu, Hao Li, Fenglan Chu, Xi Zhou, Rui Xie, Qiongqiong Wei, Shiming Yang, Tao Li, Sicheng Liang, Muhan Lu

Summary: Metabolism is the biochemical processes that produce or consume energy in living organisms, and cancer is considered a metabolic disease. Long non-coding RNAs play a role in regulating gene expression in cancer metabolism, potentially providing novel therapeutic targets for cancer.

ONCOLOGY REPORTS (2021)

Add to Collection

Article Microbiology

Mechanisms Behind the Indirect Impact of Metabolic Regulators on Virulence Factor Production in Staphylococcus aureus

Amelia C. Stephens, Lance R. Thurlow, Anthony R. Richardson

Summary: This study investigates the interaction between the Agr quorum sensing system and metabolic regulators CcpA and CodY in Staphylococcus aureus, shedding light on their impact on virulence factor expression and providing evidence of indirect regulatory mechanisms.

MICROBIOLOGY SPECTRUM (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Impact of Lipid Metabolism on Macrophage Polarization: Implications for Inflammation and Tumor Immunity

Evros Vassiliou, Renalison Farias-Pereira

Summary: Lipids play a crucial role in modulating macrophage functions through intricate signaling pathways. This review focuses on the relationship between lipid metabolism and macrophage functions, and explores potential molecular targets for macrophage-related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Review Oncology

Impact of Lipid Metabolism on Antitumor Immune Response

Nesrine Mabrouk, Baptiste Lecoeur, Ali Bettaieb, Catherine Paul, Frederique Vegran

Summary: Lipid metabolism reprogramming can affect the function and phenotype of immune cells in the tumor microenvironment, potentially leading to the failure of anticancer therapies. Recent studies have shown that metabolic reprogramming can modulate the antitumor response by immune cells. The altered energy metabolism may be responsible for the failure of antitumor immunity.

CANCERS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression

Monika Sharma, Martin P. Schlegel, Milessa S. Afonso, Emily J. Brown, Karishma Rahman, Ada Weinstock, Brian E. Sansbury, Emma M. Corr, Coen van Solingen, Graeme J. Koelwyn, Lianne C. Shanley, Lauren Beckett, Daniel Peled, Juan J. Lafaille, Matthew Spite, P'ng Loke, Edward A. Fisher, Kathryn J. Moore

CIRCULATION RESEARCH (2020)

Add to Collection

Editorial Material Cardiac & Cardiovascular Systems

Introduction to the Obesity, Metabolic Syndrome, and CVD Compendium

Kathryn J. Moore, Ravi Shah

CIRCULATION RESEARCH (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity

Ada Weinstock, Hernandez Moura Silva, Kathryn J. Moore, Ann Marie Schmidt, Edward A. Fisher

CIRCULATION RESEARCH (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

An Eclectic Cast of Cellular Actors Orchestrates Innate Immune Responses in the Mechanisms Driving Obesity and Metabolic Perturbation

Lakshmi Arivazhagan, Henry H. Ruiz, Robin A. Wilson, Michaele B. Manigrasso, Paul F. Gugger, Edward A. Fisher, Kathryn J. Moore, Ravichandran Ramasamy, Ann Marie Schmidt

CIRCULATION RESEARCH (2020)

Add to Collection

Article Multidisciplinary Sciences

Enhanced glycolysis and HIF-1α activation in adipose tissue macrophages sustains local and systemic interleukin-1β production in obesity

Monika Sharma, Ludovic Boytard, Tarik Hadi, Graeme Koelwyn, Russell Simon, Mireille Ouimet, Lena Seifert, Westley Spiro, Bo Yan, Susan Hutchison, Edward A. Fisher, Ravichandran Ramasamy, Bhama Ramkhelawon, Kathryn J. Moore

SCIENTIFIC REPORTS (2020)

Add to Collection

Review Hematology

COVID-19 and the Heart and Vasculature Novel Approaches to Reduce Virus-Induced Inflammation in Patients With Cardiovascular Disease

Bernard S. Kadosh, Michael S. Garshick, Juan Gaztanaga, Kathryn J. Moore, Jonathan D. Newman, Michael Pillinger, Ravichandran Ramasamy, Harmony R. Reynolds, Binita Shah, Judith Hochman, Glenn Fishman, Stuart D. Katz

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Myocardial infarction accelerates breast cancer via innate immune reprogramming

Emma M. Corr, Emily J. Brown, Kathleen B. Albers, Naoko Yamaguchi, Deven Narke, Martin Schlegel, Monika Sharma, Lianne C. Shanley, Tessa J. Barrett, Karishma Rahman, Valeria Mezzano, Edward A. Fisher, David S. Park, Jonathan D. Newman, Daniela F. Quail, Erik R. Nelson, Bette J. Caan, Lee W. Jones, Kathryn J. Moore

NATURE MEDICINE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Noncoding RNAs in Cardiovascular Disease: Current Knowledge, Tools and Technologies for Investigation, and Future Directions: A Scientific Statement From the American Heart Association

Saumya Das, Ravi Shah, Stefanie Dimmeler, Jane E. Freedman, Christopher Holley, Jin-Moo Lee, Kathryn Moore, Kiran Musunuru, Da-Zhi Wang, Junjie Xiao, Ke-Jie Yin

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

LDL Receptor Pathway Regulation by miR-224 and miR-520d

Alessandro G. Salerno, Coen van Solingen, Elena Scotti, Amarylis C. B. A. Wanschel, Milessa S. Afonso, Scott R. Oldebeken, Westley Spiro, Peter Tontonoz, Katey J. Rayner, Kathryn J. Moore

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

Add to Collection

Editorial Material Cardiac & Cardiovascular Systems

Crosstalk Between the Heart and Cancer Beyond Drug Toxicity

Javid Moslehi, Qing Zhang, Kathryn J. Moore

CIRCULATION (2020)

Add to Collection

Article Hematology

MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging

Milessa Silva Afonso, Narendra Verma, Coen van Solingen, Yannick Cyr, Monika Sharma, Luce Perie, Emma M. Corr, Martin Schlegel, Lianne C. Shanley, Daniel Peled, Jenny Y. Yoo, Ann Marie Schmidt, Elisabetta Mueller, Kathryn J. Moore

Summary: Recent studies have shown that miR-33 plays a crucial role in regulating metabolic pathways in brown adipocytes, with reduced levels observed in response to thermogenic activators. In mice exposed to cold, miR-33 levels in BAT are rapidly downregulated, suggesting a role in repression of adaptive thermogenesis. Inhibition of miR-33 in mice leads to increased expression of key genes involved in BAT activation and white adipose beiging, rendering mice resistant to cold challenge.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

Milessa Silva Afonso, Monika Sharma, Martin Schlegel, Coen van Solingen, Graeme J. Koelwyn, Lianne C. Shanley, Lauren Beckett, Daniel Peled, Karishma Rahman, Chiara Giannarelli, Huilin Li, Emily J. Brown, Alireza Khodadadi-Jamayran, Edward A. Fisher, Kathryn J. Moore

Summary: Inhibition of miR-33 shifts the balance of proatherosclerotic and antiatherosclerotic immune cell subsets in atherosclerotic plaques, reducing plaque burden and inflammation. This treatment also affects the expression of specific target genes in different macrophage subsets, ultimately leading to a decrease in aortic CD8+ T cells and CD4+ T-helper 1 cells, and an increase in regulatory T cells within plaques. These findings shed light on the immune mechanisms underlying the atheroprotective effects of anti-miR-33.

CIRCULATION RESEARCH (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression

Martin Schlegel, Monika Sharma, Emily J. Brown, Alexandra A. C. Newman, Yannick Cyr, Milessa Silva Afonso, Emma M. Corr, Graeme J. Koelwyn, Coen van Solingen, Jonathan Guzman, Rubab Farhat, Cyrus A. Nikain, Lianne C. Shanley, Daniel Peled, Ann Marie Schmidt, Edward A. Fisher, Kathryn J. Moore

Summary: Targeting Ntn1 in advanced atherosclerosis can ameliorate atherosclerotic inflammation and promote plaque regression by restructuring monocyte-macrophage dynamics and enhancing pathways involved in inflammation resolution.

CIRCULATION RESEARCH (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

High-Throughput Screening Identifies MicroRNAs Regulating Human PCSK9 and Hepatic Low-Density Lipoprotein Receptor Expression

Coen van Solingen, Scott R. Oldebeken, Alessandro G. Salerno, Amarylis C. B. A. Wanschel, Kathryn J. Moore

Summary: The discovery of PCSK9 and its role in LDL regulation has led to the rapid development of therapeutic PCSK9 inhibitors. Research has identified certain microRNAs that can reduce PCSK9 expression, leading to increased LDLR expression in hepatic cells, which may have therapeutic implications for manipulating LDLR expression and cholesterol levels in the liver.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Add to Collection

Meeting Abstract Hematology

Inhibition of MicroRNA-33 Reprograms the Transcriptional Landscape and Kinetic Processes of Immune Cells to Promote Atherosclerotic Plaque Regression

Milessa S. Afonso, Monika Sharma, Paul Martin Schlegel, Alireza Khodadadi-Jamayran, Coen van Solingen, Lianne Shanley, Graeme J. Koelwyn, Lauren Beckett, Daniel Peled, Karishma Rahman, Mireille Ouimet, Edward A. Fisher, Kathryn J. Moore

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.