Review
Immunology
Silvere D. Zaongo, Yanqiu Liu, Vijay Harypursat, Fangzhou Song, Huan Xia, Ping Ma, Yaokai Chen
Summary: Antiretroviral therapy (ART) is the only currently effective method to treat HIV-1 infection, but may be toxic to vital organs. Therefore, considering HIV-1 restriction factors from the innate immune system to explore novel therapeutic approaches is seen as a promising strategy by researchers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qi Xu, Ming Shi, Lu Ding, Yu Xia, Liang Luo, Xiaofang Lu, Xiaoying Zhang, David Y. B. Deng
Summary: This study found that P-selectin induces the formation of NETs through the PSGL-1 and downstream Syk/Ca2+/PAD4 signaling pathway, playing an important role in acute pancreatitis. Inhibiting the P-selectin pathway may be a promising strategy for the treatment of AP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Tianyang Li, Yang Yang, Yongqi Li, Zhengmin Wang, Faxiang Ma, Runqi Luo, Xiaoming Xu, Guo Zhou, Jianhua Wang, Junqi Niu, Guoyue Lv, Ian N. Crispe, Zhengkun Tu
Summary: Infection with SARS-CoV-2 can lead to COVID-19, which ranges from mild to moderate disease but carries the risk of morbidity and mortality. Severe cases of COVID-19 are associated with hemostasis disorders, monocyte activation, and a cytokine storm, but the connection between these manifestations is not fully understood. This study reveals that the spike protein of SARS-CoV-2 interacts with P-selectin/PGSL-1 and CD40L/CD40, leading to proinflammatory cytokine production by monocytes. These findings provide an explanation for the correlation between hypercoagulation, monocyte activation, and a cytokine storm in severely affected COVID-19 patients, and suggest a potential target for therapeutic intervention.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Camila P. Camargo, Abir K. Muhuri, Yunus Alapan, Lauren F. Sestito, Megha Khosla, Margaret P. Manspeaker, Aubrey S. Smith, Chrystal M. Paulos, Susan N. Thomas
Summary: By utilizing an engineered microfluidic device to replicate the hemodynamic microenvironment of tumor vasculature, it has been found that CD8(+) T cells can interact with adhesive ligands and improve their ability to infiltrate tumors, leading to enhanced tumor control in adoptive cell therapy combined with immune checkpoint blockade.
Article
Oncology
Joao L. Pereira, Patricia Cavaco, Ricardo C. da Silva, Ivette Pacheco-Leyva, Stefan Mereiter, Ricardo Pinto, Celso A. Reis, Nuno R. dos Santos
Summary: PSGL-1, a membrane-bound glycoprotein expressed in lymphoid and myeloid cells, plays a role in T cell trafficking and homing, and has been linked to lymphoid malignancies. The expression of PSGL-1 promotes T cell lymphoma development and dissemination to various organs.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biophysics
Yuncheng Man, Erdem Kucukal, Shichen Liu, Ran An, Utku Goreke, William J. Wulftange, Zoe Sekyonda, Allison Bode, Jane A. Little, Deepa Manwani, Evi X. Stavrou, Umut A. Gurkan
Summary: Neutrophil recruitment to the inflamed endothelium is crucial in the development of vaso-occlusive crisis in sickle cell disease (SCD). However, there is no standardized approach for assessing neutrophil recruitment to the inflamed endothelium for personalized risk stratification and therapeutic response prediction in SCD. This study presents a microfluidic device functionalized with E-selectin as a strategy to assess neutrophil binding under physiologic flow in normoxia and hypoxia in SCD. The findings provide mechanistic insight into neutrophil-endothelial interactions under hypoxia and offer a clinically feasible means for assessing neutrophil binding to E-selectin using clinical whole blood samples, which can guide therapeutic decisions for SCD patients.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Oncology
Hans-Ake Fabricius, Sarah Starzonek, Tobias Lange
Summary: Platelets, as the smallest cells in the blood stream, play crucial roles in hemostasis, inflammation, immunity, and tissue repair. In malignancies, platelets are also involved in promoting metastasis and resistance to anti-tumor treatment. The complex interaction between platelets and cancer cells is still not fully understood, although various surface molecules and transduction mechanisms have been identified.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Dennis Jones, Zixiong Wang, Ivy X. Chen, Sue Zhang, Rohin Banerji, Pin-Ji Lei, Hengbo Zhou, Victoria Xiao, Cecilia Kwong, Jan Willem M. van Wijnbergen, Ethel R. Pereira, Benjamin J. Vakoc, Peigen Huang, Hadi T. Nia, Timothy P. Padera
Summary: Metastatic lesions in lymph nodes generate solid stress that hinders lymphocyte infiltration, but relieving solid stress can significantly increase the presence of lymphocytes in lymph node lesions.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
David F. Caianiello, Mengwen Zhang, Jason D. Ray, Rebecca A. Howell, Jake C. Swartzel, Emily M. J. Branham, Egor Chirkin, Venkata R. Sabbasani, Angela Z. Gong, David M. McDonald, Viswanathan Muthusamy, David A. Spiegel
Summary: Targeted protein degradation (TPD) is a promising therapeutic strategy, with MoDE-A technology enabling degradation of extracellular proteins. Experimental evidence shows the modularity of MoDE-A molecules in inducing specific protein depletion, opening up new possibilities for disease treatment.
NATURE CHEMICAL BIOLOGY
(2021)
Review
Virology
Silvere D. Zaongo, Yaokai Chen
Summary: P-selectin glycoprotein ligand-1 (PSGL-1) plays a crucial role in HIV infection. It inhibits HIV reverse transcription and reduces the infectivity of HIV virions produced by infected cells. However, PSGL-1 expression negatively affects immune cell functions, potentially predicting HIV disease progression.
Review
Biochemistry & Molecular Biology
Liadys Mora Lagares, Marjana Novic
Summary: ABC transporters, especially P-glycoprotein (P-gp), play a critical role in drug bioavailability and toxicity. Efforts to reverse multidrug resistance (MDR) associated with overexpression of P-gp have been extensive but have yet to yield effective inhibitors due to their toxic effects. Computational studies and in silico models have shown promise in accelerating the development of P-gp inhibitors and understanding drug-transporter interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
Herve Falet, Leonardo Rivadeneyra, Karin M. Hoffmeister
Summary: This review focuses on the role of glycans in human and mouse platelet and megakaryocyte physiology, and specifically examines the effects of glycan biosynthesis and degradation on platelet numbers and megakaryocyte function.
Article
Virology
Jonathan Burnie, Arvin Tejnarine Persaud, Laxshaginee Thaya, Qingbo Liu, Huiyi Miao, Stephen Grabinsky, Vanessa Norouzi, Paolo Lusso, Vera A. Tang, Christina Guzzo
Summary: PSGL-1 plays diverse roles in HIV-1 infection due to its functional activity on virion surfaces and broad incorporation among a wide range of viral isolates.
Article
Cell Biology
Lalitha Nayak, David R. Sweet, Asha Thomas, Stephanie D. Lapping, Kenneth Kalikasingh, Annmarie Madera, Vinesh Vinayachandran, Roshan Padmanabhan, Neelakantan T. Vasudevan, Jay T. Myers, Alex Y. Huang, Alvin Schmaier, Nigel Mackman, Xudong Liao, Andrei Maiseyeu, Mukesh K. Jain
Summary: Arterial and venous thrombosis are major global diseases with common mechanisms involving neutrophils. This study identified neutrophils as key effectors in thrombosis and demonstrated the feasibility of targeting them using immunoregulatory nanoparticles. Moreover, key molecular events and regulators of neutrophil activation were identified, providing potential targets for therapeutics against immunothrombosis.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Julia M. DeRogatis, Karla M. Viramontes, Emily N. Neubert, Monique L. Henriquez, Christian F. Guerrero-Juarez, Roberto Tinoco
Summary: Therapeutically targeting PSGL-1 can reinvigorate antitumor immunity by enhancing effector T-cell responses and reducing regulatory T cells, thus delaying tumor growth in a melanoma mouse model.
CANCER IMMUNOLOGY RESEARCH
(2022)
