Article
Otorhinolaryngology
Tyler Van Heest, Nathan Rubin, Samir S. Khariwala
Summary: This prospective cohort study investigated the frequency and patterns of posttreatment smoking cessation in patients with head and neck squamous cell carcinoma (HNSCC). The results showed that a significant proportion of patients who were smokers at the time of diagnosis continued to smoke after treatment. Patients who successfully quit smoking were most likely to do so in the first 6 months after treatment.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Remi Valter, Ophelie Guyonvarch, Ingrid Allagbe, Anne-Laurence Le Faou
Summary: The study aimed to explore factors associated with one-month abstinence in dual users compared to exclusive smokers in French smoking cessation services (SCS). The results showed that dual users had similar cessation rates as exclusive smokers, but presented more comorbidities and higher nicotine dependence levels. Predictors of abstinence in dual users included employment or retirement, multiple previous quit attempts, low nicotine dependence, high motivation to quit, and regular follow-up consultations. The findings suggest that dual users seeking help in SCS can benefit from support to achieve abstinence, despite their higher nicotine dependence and comorbidities. Further qualitative research is needed to provide tailored interventions for this specific group of smokers.
PREVENTIVE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jamie E. Spahn, Salomon A. Stavchansky, Zhengrong Cui
Summary: Electronic cigarettes, marketed as smoking cessation devices, have raised concerns over safety due to their rapid adoption and lack of regulation. More research is needed on these devices and nicotine solutions, given the current lack of regulation in the market.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Editorial Material
Otorhinolaryngology
Thorsen Haugen, Joshua Senter, Priscilla Pichardo
Summary: Along with other goals of medicine, disease prevention, specifically in head and neck cancer, is an important aspect for head and neck surgeons to consider in order to provide maximum benefit to patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Multidisciplinary Sciences
Mark Ooms, Behrus Puladi, Khosrow Siamak Houschyar, Marius Heitzer, Ashkan Rashad, Johannes Bickenbach, Frank Hoelzle, Ali Modabber
Summary: Smoking has some effect on the perfusion of microvascular free flaps, but it does not decrease the flap survival rate.
SCIENTIFIC REPORTS
(2022)
Article
Substance Abuse
Noreen L. Watson, Kristin E. Mull, Jonathan B. Bricker
Summary: Research suggests that daily e-cigarette use is associated with lower odds of quitting smoking among treatment-seeking smokers, especially among those with lower nicotine dependence and who initiate daily use after starting an intervention.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Public, Environmental & Occupational Health
Aline F. Fares, Yao Li, Mei Jiang, M. Catherine Brown, Andrew C. L. Lam, Reenika Aggarwal, Sabine Schmid, Natasha B. Leighl, Frances A. Shepherd, Zhichao Wang, Nancy Diao, Angela S. Wenzlaff, Juntao Xie, Takashi Kohno, Neil E. Caporaso, Curtis Harris, Hongxia Ma, Matthew J. Barnett, Leticia Ferro Leal, G. Fernandez-Tardon, Manica Perez-Rios, Michael P. A. Davies, Fiona Taylor, Ben Schoettker, Paul Brennan, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Swiatkowska, Dana Mates, Milan Savic, Hermann Brenner, Angeline Andrew, Angela Cox, John K. Field, Alberto Ruano-Ravina, Sanjay S. Shete, Adonina Tardon, Ying Wang, Loic Le Marchand, Rui Manuel Reis, Matthew B. Schabath, Chu Chen, Hongbing Shen, Brid M. Ryan, Maria Teresa Landi, Kouya Shiraishi, Jie Zhang, Ann G. Schwartz, Ming S. Tsao, David C. Christiani, Ping Yang, Rayjean J. Hung, Wei Xu, Geoffrey Liu
Summary: This large-scale study conducted in multiple countries and regions worldwide found that the duration of smoking abstinence is associated with overall survival in patients with NSCLC, even when diagnosed at a later lung-cancer screening visit.
LANCET PUBLIC HEALTH
(2023)
Article
Oncology
John J. W. Lee, Vijay Kunaratnam, Christina J. H. Kim, Martha Pienkowski, Katrina Hueniken, Axel Sahovaler, Andrew C. L. Lam, Joel C. Davies, Catherine M. Brown, John R. De Almeida, Shao Hui Huang, John N. Waldron, Anna Spreafico, Rayjean J. Hung, Wei Xu, David P. Goldstein, Geoffrey Liu
Summary: Smoking cessation and long-term abstinence are associated with improved overall survival and HNSCC-specific survival in patients with HNSCC. Former smokers have a reduced risk of overall mortality compared with current smokers, especially those who quit smoking more than 10 years before diagnosis. Long-term abstinence is significantly associated with a decreased risk of HNSCC-specific death.
Review
Public, Environmental & Occupational Health
Ailsa R. Butler, Nicola Lindson, Thomas R. Fanshawe, Annika Theodoulou, Rachna Begh, Peter Hajek, Hayden McRobbie, Chris Bullen, Caitlin Notley, Nancy A. Rigotti, Jamie Hartmann-Boyce
Summary: Moderate certainty evidence suggests that nicotine electronic cigarettes can be used to quit smoking combustible cigarettes. However, the duration of e-cigarette use after smoking cessation attempts remains uncertain. This study analyzed data from 19 studies and found that 54% of individuals assigned to e-cigarette conditions continued using e-cigarettes at 6 months or longer. Among those who successfully quit smoking, 70% were still using e-cigarettes at six months or longer.
PREVENTIVE MEDICINE
(2022)
Letter
Clinical Neurology
Neal S. Parikh, Babak B. Navi, Alexander E. Merkler, Hooman Kamel
Summary: This cross-sectional study examines the prevalence of electronic cigarette use among actively smoking stroke survivors in the US and its association with at least one smoking cessation attempt in the past year.
Article
Substance Abuse
Sara Kalkhoran, Joanna M. Streck, Gina R. Kruse, Nancy A. Rigotti, Giselle K. Perez, Susan Regan, Colin J. Ponzani, Alona Muzikansky, Elyse R. Park, Jamie S. Ostroff
Summary: Using a mixed-methods approach, this study aimed to describe longitudinal e-cigarette use over 6 months after a cancer diagnosis and assess the association between e-cigarette use and smoking cessation among cancer patients in a smoking cessation trial. Results showed that e-cigarette use declined over time and was not significantly associated with smoking abstinence at 6 months. Individuals with easier access to evidence-based smoking cessation treatment were less likely to use e-cigarettes.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Substance Abuse
Elias M. Klemperer, Janice Y. Bunn, Amanda M. Palmer, Tracy T. Smith, Benjamin A. Toll, K. Michael Cummings, Matthew J. Carpenter
Summary: This study found that quitting electronic nicotine delivery systems (ENDS) is not associated with quitting combustible tobacco products (CTPs) among current smokers, but there is a possible risk of relapse to smoking associated with quitting ENDS among former smokers.
Editorial Material
Otorhinolaryngology
Elliot Y. Koo, Kyle J. Kozak, Virginie Achim, Barry L. Wenig
Summary: The study found that head and neck cancer specialists generally have unfavorable attitudes towards electronic cigarettes for smoking cessation, but those familiar with tobacco harm reduction are more likely to inquire about e-cigarette use and have a more positive view on their benefits for quitting smoking.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Richard S. Matulewicz, Jeffrey C. Bassett, Lorna Kwan, Scott E. Sherman, William J. McCarthy, Christopher S. Seigal, John L. Gore
Summary: A strategy that includes provider education and a customized clinical decision support tool can facilitate provider use of evidence-based practices for tobacco cessation in a urology clinic.
Editorial Material
Biochemistry & Molecular Biology
Yael Bar-Zeev
Summary: Although electronic cigarettes may be a better option for pregnant women to quit smoking compared to nicotine replacement therapy, concerns about low cessation rates and unknown long-term harm hinder enthusiasm.
Letter
Medicine, Research & Experimental
Neelaysh Vukkadala, Eben Rosenthal
Article
Otorhinolaryngology
Larissa Sweeny, Erica Mayland, Brian P. Swendseid, Joseph M. Curry, Alexandra E. Kejner, Carissa M. Thomas, Joshua J. Kain, Steve B. Cannady, Kendall Tasche, Eben L. Rosenthal, Michael DiLeo, Adam J. Luginbuhl, Hailey Theeuwen, Juliana R. Sarwary, Daniel Petrisor, Mark K. Wax
Summary: This retrospective multi-institutional review found that most patients undergoing free flap reconstruction for osteonecrosis experienced improvement in diet function, with low rates of osteonecrosis and cancer recurrence. Quality-of-life outcomes were above average, indicating good return of function and quality of life.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Multidisciplinary Sciences
Quan Zhou, Johana C. M. Vega Leonel, Michelle Rai Santoso, Christy Wilson, Nynke S. van den Berg, Carmel T. Chan, Muna Aryal, Hannes Vogel, Romain Cayrol, Michael J. Mandella, Frank Schonig, Guolan Lu, Sanjiv S. Gambhir, Michael E. Moseley, Eben L. Rosenthal, Gerald A. Grant
Summary: The study assessed the feasibility of detecting HGG using near-infrared fluorescent antibody targeting EGFR, and found that tumor specific uptake of panitumumab-IRDye800 provided remarkable contrast and a flexible imaging window for fluorescence-guided identification of HGGs despite modest EGFR expression. Age, combined with IDH-wildtype cerebral tumor, was predictive of greater EGFR protein expression in human tumors.
SCIENTIFIC REPORTS
(2021)
Review
Biochemical Research Methods
Feredun Azari, Gregory Kennedy, Elizabeth Bernstein, Constantinos Hadjipanayis, Alexander L. Vahrmeijer, Barbara L. Smith, Eben Rosenthal, Baran Sumer, Jie Tian, Eric R. Henderson, Amy Lee, Quyen Nguyen, Summer L. Gibbs, Brian W. Pogue, Daniel A. Orringer, Cleopatra Charalampaki, Linda W. Martin, Janos L. Tanyi, Major Kenneth Lee, John Y. K. Lee, Sunil Singhal
Summary: Surgery plays a crucial role in the treatment of solid organ malignancies, with intraoperative molecular imaging (IMI) emerging as a potential tool to address various challenges faced by cancer surgeons. Recent advances in tracer development, near-infrared camera approvals, and clinical trials have shown promising progress in the field of IMI. The use of IMI is increasingly recognized as an improvement to standard oncologic surgical resections and is expected to advance the field of cancer surgery in the coming years.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Review
Oncology
Lorraine J. Lauwerends, Pieter B. A. A. van Driel, Robert J. Baatenburg de Jong, Jose A. U. Hardillo, Senada Koljenovic, Gerwin Puppels, Laura Mezzanotte, Clemens W. G. M. Lowik, Eben L. Rosenthal, Alexander L. Vahrmeijer, Stijn Keereweer
Summary: Fluorescence-guided surgery is primarily focused on providing real-time guidance for surgeons to delineate tumors, and the assessment of its clinical value should concentrate on potential changes in intraoperative decision making. The analysis of existing trials and recommendations on reporting methods for changes in intraoperative decision making are crucial for the widespread clinical implementation of fluorescence-guided surgery.
Article
Otorhinolaryngology
Marisa E. Hom, Eben L. Rosenthal
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Article
Multidisciplinary Sciences
Uriel Y. Moreno-Nieves, Joshua K. Tay, Saumyaa Saumyaa, Nina B. Horowitz, June Ho Shin, Imran A. Mohammad, Bogdan Luca, David C. Mundy, Gunsagar S. Gulati, Nikita Bedi, Serena Chang, Chen Chen, Michael J. Kaplan, Eben L. Rosenthal, F. Christopher Holsinger, Vasu Divi, Fred M. Baik, Davud B. Sirjani, Andrew J. Gentles, Aaron M. Newman, Aharon G. Freud, John B. Sunwoo
Summary: Despite the reported antitumor functions of NK cells, their contribution to tumor control in humans remains controversial due to incomplete understanding of the NK cell states within the tumor microenvironment (TME). This study demonstrates that peripheral circulating NK cells differentiate into two divergent pathways within the TME, resulting in different end states, with one having potent in vivo antitumor activity. This finding provides insight into the origin of certain NK cell states within the TME and identifies specific NK cell phenotypes with the greatest antitumor activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Otorhinolaryngology
Melanie D. Hicks, Alyssa K. Ovaitt, Jason C. Fleming, Anna G. Sorace, Patrick N. Song, Ameer Mansur, Yolanda E. Hartman Bs, Eben L. Rosenthal, Jason M. Warram, Carissa M. Thomas
Summary: The study demonstrates that IntegriSense750 shows better predictive performance in flap compromise compared to ICG, with higher signal-to-background ratio. This fluorescence agent may enhance the identification of flap necrosis and potentially improve patient outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Medicine, Research & Experimental
Kayva L. Crawford, Fernanda V. Pacheco, Yu-Jin Lee, Marisa Hom, Eben L. Rosenthal, Quyen T. Nguyen, Ryan K. Orosco
Summary: Fluorescence-guided surgery (FGS) is a rapidly developing intraoperative technology with many contrast agents under investigation. This review focused on the current state of FGS clinical trials in Otolaryngology, particularly its oncologic applications. A total of 19 studies were included, with 17 focused on FGS for oncologic resection and lymph node detection.
Article
Oncology
Rahul Pal, Marisa E. Hom, Nynke S. van den Berg, Thinzar M. Lwin, Yu-Jin Lee, Andrey Prilutskiy, William Faquin, Eric Yang, Srinivas V. Saladi, Mark A. Varvares, Eben L. Rosenthal, Anand T. N. Kumar
Summary: This study provides the first clinical evidence that fluorescence lifetime (FLT) imaging can provide tumor specificity at the cellular level in patients injected with an EGFR-targeted near infrared fluorescent probe. FLT within EGFR-overexpressing cancer cells is significantly longer than in normal tissue, allowing for high sensitivity and specificity for tumor classification. The mean tissue FLT is spatially correlated with tumor-specific EGFR expression and can be detected through thick biological tissue, suggesting the potential for clinical applications in image guided surgery and cancer diagnostics.
CLINICAL CANCER RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Giri Krishnan, Aidan Cousins, Nguyen Pham, Valentina Milanova, Melanie Nelson, Shridhar Krishnan, Anil Shetty, Nynke van den Berg, Eben Rosenthal, Suren Krishnan, Peter-John Wormald, Andrew Foreman, Benjamin Thierry
Summary: This study demonstrates the potential of a novel mannose-labeled magnetic iron oxide tracer to overcome the limitations of false negative results in sentinel lymph node biopsy for head and neck cancers. The tracer showed high affinity to the sentinel node and provided a means for intraoperative signal-based node status indication.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
Kavita Prasad, Rahul Sharma, Daniel Habib, Robert Sinard, Kyle Mannion, Sarah Rohde, Alexander Langerman, James Netterville, Eben Rosenthal, James Lewis, Michael C. Topf
Summary: The study aimed to evaluate the presence of carcinoma in re-resection specimens following initial positive margins during head and neck cancer surgery and its impact on oncologic outcomes. A retrospective chart review was conducted on patients who underwent curative-intent surgery for oral cavity cancer. The results showed that fewer than a third of re-resections contained further malignancy, suggesting difficulty in locating the initial positive margin. Conclusion: The presence of cancer in re-resection specimens and final positive margin status was associated with worse overall survival, but age, T4 disease, and surgery for recurrent oral cavity cancer were independently associated with overall survival.
Proceedings Paper
Engineering, Biomedical
Eric R. Henderson, Paul M. Werth, Xiaochun Xu, Lesley Jarvis, Keith D. Paulsen, P. Jack Hoopes, Eben L. Rosenthal, Brian W. Pogue, Kimberley S. Samkoe
Summary: The study successfully tested a fluorescent dye for sarcomas and found that it maintained its targeting effect even after chemotherapy and radiation, suggesting its potential application in fluorescence-guided surgery.
MOLECULAR-GUIDED SURGERY: MOLECULES, DEVICES, AND APPLICATIONS VIII
(2022)
Article
Medicine, Research & Experimental
Quan Zhou, S. Nynke van den Berg, L. Eben Rosenthal, Michael Iv, Michael Zhang, C. M. Johana Vega Leonel, Shannon Walters, Naoki Nishio, Monica Granucci, Roan Raymundo, Grace Yi, Hannes Vogel, Romain Cayrol, Yu-Jin Lee, Guolan Lu, Marisa Hom, Wenying Kang, Melanie Hayden Gephart, Larry Recht, Seema Nagpal, Reena Thomas, Chirag Patel, A. Gerald Grant, Gordon Li
Summary: The study evaluated the safety and efficacy of using panitumumab-IRDye800 as an imaging agent for high-grade gliomas, showing that it provided good tumor contrast at both doses. The 100 mg dose was able to detect smaller tumor fragments, making it more suitable for intraoperative imaging.
Article
Medicine, Research & Experimental
Giri Krishnan, Nynke S. van den Berg, Naoki Nishio, Georgina Juniper, Jaqueline Pei, Quan Zhou, Guolan Lu, Yu-Jin Lee, Kimberly Ramos, Andrei H. Iagaru, Fred M. Baik, Alexander D. Colevas, Brock A. Martin, Eben L. Rosenthal
Summary: The study showed that intravenous infusion of a tumor-targeted tracer could accurately identify sentinel and metastatic lymph nodes, potentially improving the practice of SLNB surgery.