Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus

IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction

(2013) Stéphanie Bibert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant patients

(2013) Dayana Bravo et al.   JOURNAL OF MEDICAL VIROLOGY

Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

(2013) David Booth et al.   NATURE GENETICS

A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription

(2013) Sreedhar Chinnaswamy et al.   PLoS One

State-of-the-Art Monitoring of Cytomegalovirus-Specific Cell-Mediated Immunity After Organ Transplant: A Primer for the Clinician

(2012) A. Egli et al.   CLINICAL INFECTIOUS DISEASES

HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons

(2012) Emmanuel Thomas et al.   GASTROENTEROLOGY

Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection

(2012) Daryl T.–Y. Lau et al.   GASTROENTEROLOGY

Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection

(2012) Janett Fischer et al.   HEPATOLOGY

Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection

(2012) Shinya Maekawa et al.   HEPATOLOGY

Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells

(2012) Z. Yin et al.   JOURNAL OF IMMUNOLOGY

IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population

(2012) Xiaodong Shi et al.   PLoS One

Increased Risk of Severe Hepatitis C Virus Recurrence After Liver Transplantation in Patients With a T Allele of IL28B rs12979860

(2012) Elisa Cisneros et al.   TRANSPLANTATION

IFN-  enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing

(2011) F. Spadaro et al.   BLOOD

Interferon lambdas: the next cytokine storm

(2011) C. Kelly et al.   GUT

Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state

(2011) Hiromi Abe et al.   JOURNAL OF MEDICAL VIROLOGY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Genetic Variation of the IL-28B Promoter Affecting Gene Expression

(2011) Masaya Sugiyama et al.   PLoS One

Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

(2011) Katherine R Smith et al.   Genome Medicine

Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C

(2010) Masao Honda et al.   GASTROENTEROLOGY

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C

(2010) Michael T. Dill et al.   GASTROENTEROLOGY

Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything

(2010) A. Loewendorf et al.   JOURNAL OF INTERNAL MEDICINE

Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1

(2010) Zachary J. Miknis et al.   JOURNAL OF MOLECULAR BIOLOGY

The Clinical Utility of Whole Blood Versus Plasma Cytomegalovirus Viral Load Assays for Monitoring Therapeutic Response

(2010) Luiz F. Lisboa et al.   TRANSPLANTATION

Interferon-λ Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

(2009) Hans Henrik Gad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy

(2009) Magdalena Sarasin-Filipowicz et al.   NATURE MEDICINE

Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients

(2008) Adrian Egli et al.   Journal of Translational Medicine