A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis

(2013) Yannick Simonin et al.   PLoS Pathogens

Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells

(2013) Amy E. L. Stone et al.   PLoS Pathogens

Predicting sustained viral response to hepatitis C using a rapid and simple IL28B rs8099917 genotyping assay

(2012) Wei Li et al.   ANTIVIRAL RESEARCH

Hepatitis C virus NS3/4A protease blocks IL-28 production

(2012) Qiang Ding et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons

(2012) Emmanuel Thomas et al.   GASTROENTEROLOGY

IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication

(2012) H. Shindo et al.   JOURNAL OF VIRAL HEPATITIS

Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells

(2012) A. Kohli et al.   JOURNAL OF VIRAL HEPATITIS

Hepatic Expression of HCV RNA-Dependent RNA Polymerase Triggers Innate Immune Signaling and Cytokine Production

(2012) Guann-Yi Yu et al.   MOLECULAR CELL

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Genetics of IL28B and HCV—response to infection and treatment

(2012) C. Nelson Hayes et al.   Nature Reviews Gastroenterology & Hepatology

Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-α and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients

(2012) Montserrat de Castellarnau et al.   PLoS One

Sequence Analysis of the IL28A/IL28B Inverted Gene Duplication That Contains Polymorphisms Associated with Treatment Response in Hepatitis C Patients

(2012) Jennifer M. Reynolds et al.   PLoS One

IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population

(2012) Xiaodong Shi et al.   PLoS One

Host interleukin-28B genetic variants versus viral kinetics in determining responses to standard-of-care for Asians with hepatitis C genotype 1

(2011) Chung-Feng Huang et al.   ANTIVIRAL RESEARCH

IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

(2011) J-Y Chen et al.   GENES AND IMMUNITY

Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response

(2011) Yasuhiro Asahina et al.   HEPATOLOGY

Polymorphism near the IL28B gene in Korean hepatitis C virus-infected patients treated with peg-interferon plus ribavirin

(2011) KwangSoo Lyoo et al.   JOURNAL OF CLINICAL VIROLOGY

Host genomics and HCV treatment response

(2011) Paul J Clark et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

VPg-Primed RNA Synthesis of Norovirus RNA-Dependent RNA Polymerases by Using a Novel Cell-Based Assay

(2011) C. V. Subba-Reddy et al.   JOURNAL OF VIROLOGY

Hierarchies of NF-κB target-gene regulation

(2011) Stephen T Smale   NATURE IMMUNOLOGY

A Cell-Based Assay for RNA Synthesis by the HCV Polymerase Reveals New Insights on Mechanism of Polymerase Inhibitors and Modulation by NS5A

(2011) C. T. Ranjith-Kumar et al.   PLoS One

Genetic Variation of the IL-28B Promoter Affecting Gene Expression

(2011) Masaya Sugiyama et al.   PLoS One

IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients

(2011) Mauricio Venegas   WORLD JOURNAL OF GASTROENTEROLOGY

Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort

(2011) Katherine R Smith et al.   Genome Medicine

Defining Emerging Roles for NF-κB in Antivirus Responses: Revisiting the Interferon-β Enhanceosome Paradigm

(2011) Siddharth Balachandran et al.   PLoS Pathogens

Evolving epidemiology of hepatitis C virus

(2010) D. Lavanchy   CLINICAL MICROBIOLOGY AND INFECTION

Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics

(2010) B. E. Stranger et al.   GENETICS

IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy

(2010) Hiromi Abe et al.   JOURNAL OF HEPATOLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE