Article
Medicine, General & Internal
Sang-Yu Ying, Yao-Ren Hu, Guo-Sheng Gao, Ke-Hong Lou, Zhen Huang
Summary: The meta-analysis revealed a potential association between IL-28B genetic polymorphisms and response to PEG-IFN-alpha in patients with chronic hepatitis B. Especially, the rs12979860 CC genotype and rs8099917 TT genotype were associated with more significant treatment response among certain subgroups of patients.
FRONTIERS IN MEDICINE
(2021)
Review
Virology
Yi-Wen Huang, Albert Qin, Chan-Yen Tsai, Pei-Jer Chen
Summary: Ropeginterferon alfa-2b is a promising treatment option for MPN and chronic viral hepatitis due to its favorable pharmacokinetic profile and demonstrated efficacy in clinical studies. Administered once every two weeks, it has shown to be well-tolerated and effective in treating chronic hepatitis B, C, and D.
Article
Immunology
Andrea Marques Vieira da Silva, Lucia Elena Alvarado-Arnez, Tamiris Azamor, Leonardo Ribeiro Batista-Silva, Thyago Leal-Calvo, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro-Alves, Fernanda de Souza Gomes Kehdy, Patricia Cristina da Costa Neves, Camilla Bayma, Jane da Silva, Alessandro Fonseca de Souza, Marcelo Muller, Elisabete Ferreira de Andrade, Ana Carolina Magalhaes Andrade, Eliane Matos dos Santos, Janaina Reis Xavier, Maria De Lourdes De Sousa Maia, Rolando Paez Meireles, Hugo Nodarse Cuni, Guilherme Becker Sander, Paulo Dornelles Picon, Denise C. S. Matos, Milton Ozorio Moraes
Summary: The study found that specific genotypes in the IFNL3/4 gene region can serve as markers for predicting treatment outcomes for patients with chronic hepatitis C (CHC), and observed that certain genotypes may influence immune response and levels of inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jose Maria Cardoso, Ana Clara Ribeiro, Constanca Palos, Luis Proenca, Susana Noronha, Ricardo Castro Alves
Summary: This study aimed to investigate whether individuals carrying single nucleotide polymorphisms (SNPs) in the IL-1 gene cluster were more susceptible to develop peri-implantitis. By analyzing genetic variations in 20 subjects, it was found that the mutated alleles of IL-1A and IL-1B genes were more prevalent in the peri-implantitis group, indicating a potential link between IL-1 genotype and peri-implantitis.
Review
Immunology
David E. Ochayon, Stephen N. Waggoner
Summary: This article discusses the important role of cytokines in regulating immune responses, particularly the impact of mixed types of cytokines on immune responses, and their significance in disease pathogenesis and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dolores Canales Siguero, Carmen Garcia-Munoz, Francisco Martinez de la Torre, Jose Miguel Ferrari Piquero, Miguel Angel Granados Ruiz
Summary: This study described the efficacy and safety of interferon beta-1B treatment in two infants under one year of age with viral myocarditis, showing recovery of cardiac function in both cases after six months. This is the first published series of cases in infants of this age group treated with interferon beta-1B.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Virology
Chia-Min Wu, Fu-Hsiung Su, Chih-Hsin Muo, Jou-Chen Huang, Meei-Maan Wu, Chih-Ching Yeh
Summary: This study found that patients with HCV infection treated with PegIFN/RBV therapy had a significantly increased risk of retinopathy, particularly retinal hemorrhage.
Article
Multidisciplinary Sciences
Chih-Chi Wang, Kuang-Tzu Huang, Kuang-Den Chen, Li-Wen Hsu, Chih-Che Lin, King-Wah Chiu
Summary: The genetic polymorphisms of miR-122 and IL-28B are associated with HCC recurrence after LDLT, with hepatic miR-122 expression levels varying based on different genotypes and fatty liver conditions.
Article
Infectious Diseases
Seham Mahrous Zaki, Hanan Samir Ahmed, Monkez Motieh Yousif, Eman Mohamed Awad
Summary: This study evaluated IL28B gene polymorphism and its association with sustained virological response to SOF-based therapy in Egyptian patients with chronic hepatitis C.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Review
Immunology
Minghui Zheng, Jing Li, Weizhen Fang, Ling Luo, Rui Ding, Hua Zeng, Hong Luo, Xianghua Lin, Chaohui Duan
Summary: A meta-analysis explored the association between specific polymorphisms in the IFN-γ and TNF-α genes and the incidence of LC. The results showed that rs361525 is associated with LC in alcoholic liver cirrhosis and HBV-related cirrhosis, while rs2430561 is associated with LC in the Asian population and in the context of HBV-related cirrhosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lorna Leal, Elvira Couto, Sonsoles Sanchez-Palomino, Nuria Climent, Irene Fernandez, Laia Miralles, Yolanda Romero, Tania Gonzalez, Maria Jose Maleno, Blanca Pano, Judit Pich, Carlos Nicolau, Jose Maria Gatell, Montserrat Plana, Felipe Garcia
Summary: The combination of therapeutic vaccine with IFN α-2a was safe and well-tolerated in chronic HIV-1 infected individuals, but had a minimal impact on viral dynamics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Ruihua Mi, Lin Chen, Haiping Yang, Yan Zhang, Jia Liu, Qingsong Yin, Xudong Wei
Summary: The ITI regimen effectively reduces AML1-ETO fusion gene levels in patients with AML who are in hematologic remission but are fusion gene-positive. Patients showed improved response to higher dose administration and good tolerance to the treatment.
ANNALS OF HEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Bernt Hjertner, Claudia Lutzelschwab, Elise Schieck, Benjamin Nzau, Sonal Henson, Marie Sjolund, Caroline Fossum, Ulf Magnusson
Summary: This study evaluated the potential of genes considered biomarkers in humans to differentially diagnose bacterial from viral infections in pigs. Utilizing these genes, infected pigs could be effectively distinguished from healthy pigs.
Article
Medicine, General & Internal
Wang-Da Liu, Sui-Yuan Chang, Ting-Yuan Lan, Yen-Chun Lin, Jui-Hung Kao, Chun-Hua Liao, Ming-Jui Tsai, Po-Hsien Kuo, Yu-Shan Huang, Jann-Tay Wang, Wang-Huei Sheng, Song-Chou Hsieh, Bor-Luen Chiang, Yee-Chun Chen, Shan-Chwen Chang
Summary: In this case report, six patients with mild to moderate COVID-19 were treated with hydroxychloroquine for 14 days, showing no complications. However, prolonged virus shedding was still observed despite treatment with HCQ, and the impact on cytokine kinetics remained unclear.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Hosna Sarani, Behrouz Mollashahi, Mohsen Taheri, Gholamreza Bahari, Seyed Mahdi Hashemi, Mohammad Hashemi, Saeid Ghavami
Summary: The study investigated the impact of IL-1A, IL-1B, and IL-1R1 polymorphisms on lymphoma, and found that certain genotypes were associated with increased or decreased risks for different types of lymphoma.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2021)