Relevance of xenobiotic enzymes in human skinin vitromodels to activate pro-sensitizers

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

(2011) S. J. Enoch et al.   CRITICAL REVIEWS IN TOXICOLOGY

Chemical toxicity testing in vitro using cytochrome P450–expressing cell lines, such as human CYP1B1

(2011) Robert Landsiedel et al.   Nature Protocols

Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models

(2011) Christine Jäckh et al.   TOXICOLOGY IN VITRO

Integration of Langerhans-like cells into a human skin equivalent

(2010) Vesselina Laubach et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Spatial quantification and classification of skin response following perturbation using organotypic skin cultures

(2010) T. Pommerencke et al.   BIOINFORMATICS

Diphenylthiourea, a Common Rubber Chemical, Is Bioactivated to Potent Skin Sensitizers

(2010) Kristin Samuelsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Can mutagenicity information be useful in an Integrated Testing Strategy (ITS) for skin sensitization?

(2010) G. Patlewicz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Expression and Induction of Cytochrome P450 Isoenzymes in Human Skin Equivalents

(2010) M.M. Neis et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Xenobiotic metabolism gene expression in the EpiDerm™ in vitro 3D human epidermis model compared to human skin

(2010) T. Hu et al.   TOXICOLOGY IN VITRO

A potential in vitro epidermal equivalent assay to determine sensitizer potency

(2010) Guilherme G. dos Santos et al.   TOXICOLOGY IN VITRO

The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories

(2010) Natsch Andreas et al.   TOXICOLOGY IN VITRO

Para-phenylenediamine and allergic sensitization: risk modification byN-acetyltransferase 1 and 2 genotypes

(2009) B. Blömeke et al.   BRITISH JOURNAL OF DERMATOLOGY

Cutaneous Metabolic Activation of Carvoxime, a Self-Activating, Skin-Sensitizing Prohapten

(2009) Hagen Ott et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin™ and full thickness model from Episkin™

(2009) Van Luu-The et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Assessment of human epidermal model LabCyte EPI-MODEL for in vitro skin irritation testing according to European Centre for the Validation of Alternative Methods (ECVAM)-validated protocol

(2009) Masakazu Katoh et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

(2009) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

Evaluation of cytochrome P450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: Implications for the development of in vitro techniques for predictive testing of contact sensitizers

(2009) Jutta Bonifas et al.   TOXICOLOGY IN VITRO

Elicitation response characteristics to mono- and to N,N'-diacetyl-para-phenylenediamine

(2008) Brunhilde Blömeke et al.   CONTACT DERMATITIS

Skin Sensitization to p-Phenylenediamine: The Diverging Roles of Oxidation and N-Acetylation for Dendritic Cell Activation and the Immune Response

(2008) Pierre Aeby et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression ofN-Acetyltransferase in Monocyte-Derived Dendritic Cells∗

(2008) Jutta Lichter et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes

(2008) Kaeko Nakayama et al.   LIFE SCIENCES

HMOX1 and NQO1 Genes are Upregulated in Response to Contact Sensitizers in Dendritic Cells and THP-1 Cell Line: Role of the Keap1/Nrf2 Pathway

(2008) Nadège Ade et al.   TOXICOLOGICAL SCIENCES

A new dendritic cell type suitable as sentinel of contact allergens

(2008) Maximilian Schreiner et al.   TOXICOLOGY

Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens

(2008) Lina Hagvall et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Skin metabolism of aminophenols: Human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo

(2008) C. Goebel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY