Mechanistic Insights into CpG DNA and IL-15 Synergy in Promoting B Cell Chronic Lymphocytic Leukemia Clonal Expansion

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood

(2017) T M Herndon et al.   LEUKEMIA

Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis

(2017) Alain P. Vicari et al.   mAbs

Tumor microenvironment (TME)-driven immune suppression in B cell malignancy

(2016) Nicole S. Nicholas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

(2016) Lenka V. Hurton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cell regulation of the anti-tumor response and role in carcinogenesis

(2016) Marc Schwartz et al.   Journal for ImmunoTherapy of Cancer

Simultaneous assessment of NF-κB/p65 phosphorylation and nuclear localization using imaging flow cytometry

(2015) Orla Maguire et al.   JOURNAL OF IMMUNOLOGICAL METHODS

TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells

(2015) Patricia K. A. Mongini et al.   JOURNAL OF IMMUNOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy

(2015) T. A. Waldmann   Cancer Immunology Research

Thyroid nodule: first manifestation of chronic lymphocytic leukaemia

(2015) Ana Gonçalves et al.   Archives of Endocrinology Metabolism

Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era

(2015) Chadi Nabhan et al.   JAMA Oncology

Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer

(2014) A. Mishra et al.   CLINICAL CANCER RESEARCH

IL-15: a central regulator of celiac disease immunopathology

(2014) Valérie Abadie et al.   IMMUNOLOGICAL REVIEWS

The IL-15 cytokine system provides growth and survival signals in Hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells

(2014) K Ullrich et al.   LEUKEMIA

Unknown

(2014) Amit Mittal et al.   MOLECULAR MEDICINE

Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo

(2014) Guangwei Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-15.IL-15R  complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells

(2014) F. Tamzalit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of Chronic Lymphocytic Leukemia in Different Microenvironments

(2013) Yair Herishanu et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration

(2013) A. Arneja et al.   JOURNAL OF IMMUNOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

B cell receptor signaling in chronic lymphocytic leukemia

(2013) Jan A. Burger et al.   TRENDS IN IMMUNOLOGY

Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma

(2012) Egil S Blix et al.   BMC CANCER

Immunotherapeutic applications of IL-15

(2012) Michela Croce et al.   Immunotherapy

A p53 Axis Regulates B Cell Receptor-Triggered, Innate Immune System-Driven B Cell Clonal Expansion

(2012) H. Lee et al.   JOURNAL OF IMMUNOLOGY

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

(2012) F Piazza et al.   LEUKEMIA

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

(2012) Marcus Dühren-von Minden et al.   NATURE

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling

(2012) Michael P Seiler et al.   NATURE IMMUNOLOGY

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

IL-2 and IL-15 signaling complexes: different but the same

(2012) Shinji Ikemizu et al.   NATURE IMMUNOLOGY

TOLL-LIKE RECEPTORS IN CHRONIC LYMPHOCYTIC LEUKEMIA

(2012) Marta Muzio et al.   Mediterranean Journal of Hematology and Infectious Diseases

Increased serum soluble IL-15R  levels in T-cell large granular lymphocyte leukemia

(2011) J. Chen et al.   BLOOD

CD38 and chronic lymphocytic leukemia: a decade later

(2011) F. Malavasi et al.   BLOOD

Monocytes and T cells cooperate to favor normal and follicular lymphoma B-cell growth: role of IL-15 and CD40L signaling

(2011) G Epron et al.   LEUKEMIA

Unknown

(2011) Carlo Calissano et al.   MOLECULAR MEDICINE

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells

(2010) X. Liang et al.   BLOOD

CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice

(2010) M. Noda et al.   BLOOD

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype

(2010) P Neeson et al.   GENE THERAPY

IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease–associated inflammation and lymphomagenesis

(2010) Georgia Malamut et al.   JOURNAL OF CLINICAL INVESTIGATION

Proliferation centers in chronic lymphocytic leukemia: the niche where NF-κB activation takes place

(2010) B Herreros et al.   LEUKEMIA

A Rare Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Presenting in the Thyroid Gland

(2010) Joyce Shin et al.   THYROID

Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells

(2009) T. Seiler et al.   BLOOD

Interleukin-15 expression affects homeostasis and function of B cells through NK cell-derived interferon-γ

(2009) Navkiran Gill et al.   CELLULAR IMMUNOLOGY

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes

(2009) S. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and function of toll like receptors in chronic lymphocytic leukaemia cells

(2008) Marta Muzio et al.   BRITISH JOURNAL OF HAEMATOLOGY

Following the cytokine signaling pathway to leukemogenesis: a chronology

(2008) Kendall A. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

(2008) Erwan Mortier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways

(2007) D. de Totero et al.   BLOOD