Immunotherapeutic applications of IL-15

Increased IL-15 Production Is Associated with Higher Susceptibility of Memory CD4 T Cells to Simian Immunodeficiency Virus during Acute Infection

(2014) M. D. Eberly et al.   JOURNAL OF IMMUNOLOGY

The differential production of cytokines by human Langerhans cells and dermal CD14+ DCs controls CTL priming

(2012) J. Banchereau et al.   BLOOD

Inborn Errors of Human JAKs and STATs

(2012) Jean-Laurent Casanova et al.   IMMUNITY

IL-15 Can Signal via IL-15R , JNK, and NF- B To Drive RANTES Production by Myeloid Cells

(2012) M. J. Chenoweth et al.   JOURNAL OF IMMUNOLOGY

An Antibody Fusion Protein for Cancer Immunotherapy Mimicking IL-15 trans -Presentation at the Tumor Site

(2012) Vanessa Kermer et al.   MOLECULAR CANCER THERAPEUTICS

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults

(2012) Spyros A. Kalams et al.   PLoS One

Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model

(2012) P. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Despite an impaired response to IL-7, T cells from HIV-positive patients proliferate normally in response to IL-15 and its superagonist, RLI

(2011) Yovana Pacheco et al.   AIDS

The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women

(2011) Sheila M. Keating et al.   AIDS

IL-15 Interferes With Suppressive Activity of Intestinal Regulatory T Cells Expanded in Celiac Disease

(2011) Delia Zanzi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

(2011) T. A. Waldmann et al.   BLOOD

IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques

(2011) E. Lugli et al.   BLOOD

Expressing human interleukin-15 from oncolytic vesicular stomatitis virus improves survival in a murine metastatic colon adenocarcinoma model through the enhancement of anti-tumor immunity

(2011) K B Stephenson et al.   CANCER GENE THERAPY

The role of IL-15 in challenging Acquired Immunodeficiency Syndrome

(2011) Gabriella d’Ettorre et al.   CYTOKINE

Interleukin 15 as a promising candidate for tumor immunotherapy

(2011) Marek Jakobisiak et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Role of Common-Gamma Chain Cytokines in NK Cell Development and Function: Perspectives for Immunotherapy

(2011) Raffaella Meazza et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells

(2011) Jeffrey L. Wong et al.   JOURNAL OF IMMUNOTHERAPY

Differentiation Therapy: Targeting Human Renal Cancer Stem Cells with Interleukin 15

(2011) Sandy Azzi et al.   JNCI-Journal of the National Cancer Institute

Monocytes and T cells cooperate to favor normal and follicular lymphoma B-cell growth: role of IL-15 and CD40L signaling

(2011) G Epron et al.   LEUKEMIA

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

(2011) Pin-Yu Perera et al.   MICROBES AND INFECTION

Natural killer cell engineering for cellular therapy of cancer

(2011) D. R. Shook et al.   TISSUE ANTIGENS

Mutiny or scrutiny: NK cell modulation of DC function in HIV-1 infection

(2011) Galit Alter et al.   TRENDS IN IMMUNOLOGY

Interleukin-15 biology and its therapeutic implications in cancer

(2011) Jason C. Steel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4+ memory T cell loss in SIVmac251-challenged rhesus macaques

(2011) Yongjun Sui et al.   VACCINE

Natural killer-cell differentiation by myeloid progenitors

(2010) B. Grzywacz et al.   BLOOD

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

(2010) W. Ju et al.   BLOOD

Novel Gamma-Chain Cytokines as Candidate Immune Modulators in Immune Therapies for Cancer

(2010) Natasha M. Fewkes et al.   CANCER JOURNAL

Interleukin-15 and Its Receptor Augment Dendritic Cell Vaccination against the neu Oncogene through the Induction of Antibodies Partially Independent of CD4 Help

(2010) J. C. Steel et al.   CANCER RESEARCH

IL-15 increases the frequency of effector memory CD8+ T cells in rhesus monkeys immunized with HIV vaccine

(2010) Shirui Li et al.   Cellular & Molecular Immunology

Simultaneous Blockade of Multiple Immune System Inhibitory Checkpoints Enhances Antitumor Activity Mediated by Interleukin-15 in a Murine Metastatic Colon Carcinoma Model

(2010) P. Yu et al.   CLINICAL CANCER RESEARCH

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit

(2010) Antonio Valentin et al.   VACCINE

Safety and immunologic effects of IL-15 administration in nonhuman primates

(2009) C. Berger et al.   BLOOD

Human Renal Cancer Cells Express a Novel Membrane-Bound Interleukin-15 that Induces, in Response to the Soluble Interleukin-15 Receptor α Chain, Epithelial-to-Mesenchymal Transition

(2009) Krystel Khawam et al.   CANCER RESEARCH

Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy

(2009) H. Fujisaki et al.   CANCER RESEARCH

Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: How NK cells make the difference

(2009) Franco Locatelli et al.   CLINICAL IMMUNOLOGY

Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance

(2009) Rosaria Gangemi et al.   CURRENT MEDICINAL CHEMISTRY

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Trans-presentation: A novel mechanism regulating IL-15 delivery and responses

(2009) Spencer W. Stonier et al.   IMMUNOLOGY LETTERS

NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs

(2009) B. Morandi et al.   INTERNATIONAL IMMUNOLOGY

IL-15 Renders Conventional Lymphocytes Resistant to Suppressive Functions of Regulatory T Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway

(2009) M. B. Ahmed et al.   JOURNAL OF IMMUNOLOGY

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer

(2009) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251

(2009) Robert A. Dubie et al.   VIROLOGY

NK Cell Function in HIV-1 Infection

(2008) Andrea De Maria et al.   CURRENT HIV RESEARCH

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

(2008) Erwan Mortier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways

(2007) D. de Totero et al.   BLOOD