Cigarette Smoke–Induced Emphysema Exhausts Early Cytotoxic CD8+T Cell Responses against Nascent Lung Cancer Cells

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice

(2018) Jeffrey E. Gotts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non–Small Cell Lung Cancer

(2018) Nicholas M. Mark et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Impaired Tumor-infiltrating T Cells in Patients with COPD Impacts Lung Cancer Response to PD-1 Blockade

(2018) Jérôme Biton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Myeloid cell heterogeneity in cancer: not a single cell alike

(2018) Mate Kiss et al.   CELLULAR IMMUNOLOGY

Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial

(2017) Achim Rittmeyer et al.   LANCET

Macrophages as Key Drivers of Cancer Progression and Metastasis

(2017) Sebastian R. Nielsen et al.   MEDIATORS OF INFLAMMATION

Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells

(2017) Rachel M. Gibbons Johnson et al.   Frontiers in Immunology

IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer

(2016) M. S. Caetano et al.   CANCER RESEARCH

Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

(2016) Elena Tassi et al.   CANCER RESEARCH

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

(2016) Andrea Schietinger et al.   IMMUNITY

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Neutrophils in cancer

(2016) Louise W. Treffers et al.   IMMUNOLOGICAL REVIEWS

Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice

(2016) Pamela Shen et al.   INFECTION AND IMMUNITY

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

(2016) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

(2016) Giuseppe Lo Sasso et al.   Journal of Translational Medicine

Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis

(2016) Erin A. Marshall et al.   Molecular Cancer

Myeloid-derived suppressor cells and tumor escape from immune surveillance

(2016) Viktor Umansky et al.   Seminars in Immunopathology

Untangling the protease web in COPD: metalloproteinases in the silent zone

(2016) Simon R Johnson   THORAX

Per cent emphysema is associated with respiratory and lung cancer mortality in the general population: a cohort study

(2016) Elizabeth C Oelsner et al.   THORAX

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature

(2015) Els Wauters et al.   THORAX

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs

(2015) Rinat Zaynagetdinov et al.   Oncotarget

Preclinical Murine Models for Lung Cancer: Clinical Trial Applications

(2015) Amelia Kellar et al.   Biomed Research International

T-Regulatory Cells and Programmed Death 1+T Cells Contribute to Effector T-Cell Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

(2014) Suresh Gopi Kalathil et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modeling Lung Cancer Evolution and Preclinical Response by Orthotopic Mouse Allografts

(2014) C. Ambrogio et al.   CANCER RESEARCH

Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand

(2014) Maria Tsoumakidou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cigarette Smoke Exposure Impairs Dendritic Cell Maturation and T Cell Proliferation in Thoracic Lymph Nodes of Mice

(2014) C. S. Robbins et al.   JOURNAL OF IMMUNOLOGY

Cigarette Smoke Exposure Exacerbates Lung Inflammation and Compromises Immunity to Bacterial Infection

(2014) A. A. Lugade et al.   JOURNAL OF IMMUNOLOGY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

Oxidative stress and free radicals in COPD – implications and relevance for treatment

(2014) Wolfgang Domej et al.   International Journal of Chronic Obstructive Pulmonary Disease

T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice

(2013) Patricia L. Podolin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

(2013) Moshe Sade-Feldman et al.   IMMUNITY

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

(2013) Yihui Fan et al.   Protein & Cell

Short cigarette smoke exposure facilitates sensitisation and asthma development in mice

(2012) Ellen A. Lanckacker et al.   EUROPEAN RESPIRATORY JOURNAL

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection

(2012) M. A. Paley et al.   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Emphysema Scores Predict Death From COPD and Lung Cancer

(2011) Javier J. Zulueta et al.   CHEST

Affinity Thresholds for Naive CD8+ CTL Activation by Peptides and Engineered Influenza A Viruses

(2011) A. E. Denton et al.   JOURNAL OF IMMUNOLOGY

Chronic Cigarette Smoke Exposure Generates Pathogenic T Cells Capable of Driving COPD-like Disease in Rag2−/−Mice

(2010) Gregory T. Motz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD

(2010) T. Demoor et al.   EUROPEAN RESPIRATORY JOURNAL

A further review of inhalation studies with cigarette smoke and lung cancer in experimental animals, including transgenic mice

(2010) C.R.E. Coggins   INHALATION TOXICOLOGY

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance

(2010) Christopher S. Stevenson et al.   PHARMACOLOGY & THERAPEUTICS

Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Decreased Small Airway and Alveolar CD83+ Dendritic Cells in COPD

(2009) Maria Tsoumakidou et al.   CHEST

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

(2009) R. P. Young et al.   EUROPEAN RESPIRATORY JOURNAL

Lung Cancer and Chronic Obstructive Pulmonary Disease: Needs and Opportunities for Integrated Research

(2009) A. Punturieri et al.   JNCI-Journal of the National Cancer Institute

Dendritic Cells in Chronic Obstructive Pulmonary Disease

(2008) Maria Tsoumakidou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Association of Radiographic Emphysema and Airflow Obstruction with Lung Cancer

(2008) David O. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE