Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non–Small Cell Lung Cancer

Neutrophils dominate the immune cell composition in non-small cell lung cancer

(2017) Julia Kargl et al.   Nature Communications

Dysregulation of Antiviral Function of CD8+T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis

(2016) Richard T. McKendry et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung Cancer Subtypes Generate Unique Immune Responses

(2016) Stephanie E. Busch et al.   JOURNAL OF IMMUNOLOGY

The Role of Tumor-Infiltrating Lymphocytes in Development, Progression, and Prognosis of Non–Small Cell Lung Cancer

(2016) Roy M. Bremnes et al.   Journal of Thoracic Oncology

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

(2016) Martin Reck et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke–induced Lymphoid Neogenesis

(2015) Abraham B. Roos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

(2015) Julie Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

T-Regulatory Cells and Programmed Death 1+T Cells Contribute to Effector T-Cell Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

(2014) Suresh Gopi Kalathil et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Persistence of Lung CD8 T Cell Oligoclonal Expansions upon Smoking Cessation in a Mouse Model of Cigarette Smoke-Induced Emphysema

(2014) G. T. Motz et al.   JOURNAL OF IMMUNOLOGY

T helper 17 cells play a critical pathogenic role in lung cancer

(2014) S. H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis

(2013) Ying Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice

(2013) Etsuko Kurimoto et al.   RESPIRATORY RESEARCH

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased expression of CD4+IL-17+ cells in the lung tissue of patients with stable chronic obstructive pulmonary disease (COPD) and smokers

(2012) Jianquan Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cigarette Smoke Induction of Osteopontin (SPP1) Mediates TH17 Inflammation in Human and Experimental Emphysema

(2012) M. Shan et al.   Science Translational Medicine

The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

(2011) M J M Gooden et al.   BRITISH JOURNAL OF CANCER

Emphysema Scores Predict Death From COPD and Lung Cancer

(2011) Javier J. Zulueta et al.   CHEST

Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice

(2011) Ning Shen et al.   INHALATION TOXICOLOGY

IL-17RA Is Required for CCL2 Expression, Macrophage Recruitment, and Emphysema in Response to Cigarette Smoke

(2011) Kong Chen et al.   PLoS One

Effect of Emphysema on Lung Cancer Risk in Smokers: A Computed Tomography-Based Assessment

(2010) Y. Li et al.   Cancer Prevention Research

Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD

(2010) Camille Doe et al.   CHEST

Are Airflow Obstruction and Radiographic Evidence of Emphysema Risk Factors for Lung Cancer?

(2010) Fabien Maldonado et al.   CHEST

Identification of Cells Expressing IL-17A and IL-17F in the Lungs of Patients With COPD

(2010) Amanda Eustace et al.   CHEST

Cytotoxic Potential of Lung CD8+ T Cells Increases with Chronic Obstructive Pulmonary Disease Severity and with In Vitro Stimulation by IL-18 or IL-15

(2010) C. M. Freeman et al.   JOURNAL OF IMMUNOLOGY

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients

(2009) A. Di Stefano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lung Cancer and Chronic Obstructive Pulmonary Disease: Needs and Opportunities for Integrated Research

(2009) A. Punturieri et al.   JNCI-Journal of the National Cancer Institute

Association of Radiographic Emphysema and Airflow Obstruction with Lung Cancer

(2008) David O. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Common origins of lung cancer and COPD

(2008) A McGarry Houghton et al.   NATURE MEDICINE