Article
Cell Biology
Liang Gao, Chao He, Aizhen Yang, Haibing Zhou, Qingxian Lu, Raymond B. Birge, Yi Wu
Summary: This study investigates the role of Tyro3, Axl, and Mertk in the pathogenesis of rheumatoid arthritis. The results demonstrate that Axl and Mertk-deficient mice develop more severe antibody-induced arthritis, accompanied by increased levels of cytokines in the joints. In contrast, Tyro3-deficient mice show diminished joint inflammation. Furthermore, TAMs show distinct expression patterns, with monocytes expressing Axl and Mertk while neutrophils express Axl and Tyro3.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Nicki Panoskaltsis, Neil E. McCarthy, Andrew J. Stagg, Catherine J. Mummery, Mariwan Husni, Naila Arebi, David Greenstein, Claire L. Price, Hafid O. Al-Hassi, Michalis Koutinas, Athanasios Mantalaris, Stella C. Knight
Summary: This study highlights the immune-related adverse events and consequences following immunotherapy, providing insights into potential immunopathology, treatment targets, and long-term monitoring strategies for patients experiencing cytokine storms. The findings emphasize the importance of comprehensive immune monitoring and management for patients undergoing cancer immunotherapy or facing severe infections.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Mengling Huang, Ying Zhang, Ying Wang, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu, Bo Li
Summary: Active DNA demethylation plays a critical role in MAMP-triggered immune response in plants, with flg22-induced DNA demethylation tightly associated with the expression of salicylic acid signaling-related and phytoalexin biosynthesis-related genes. Lack of active DNA demethylation compromises immune response.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Immunology
Brina Stancic, Bodil Qvarfordt, Magnus M. Berglund, Nina Brenden, Mona Sydow Backman, Moa Fransson, Sofia Nordling, Peetra U. Magnusson
Summary: The study focused on using the blood endothelial cell chamber model to investigate therapeutic monoclonal antibodies in terms of cytokine release and vascular immune cell recruitment. The findings showed that different monoclonal antibodies had diverse responses in cytokine release and cell recruitment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yinan Li, Heng Zhang, Caihong Chen, Kailiang Qiao, Zhiyang Li, Jingxia Han, Xu Han, Kun Li, Keguan Lai, Ning Liu, Ang Li, Nannan Xiao, Yan Zhang, Xiangshuai Zhao, Wenqing Gao, Yang Zhang, Huijuan Liu, Tao Sun
Summary: This study suggests that tumor cells may play a role in alleviating sepsis through the secretion of specific exosomes and miRNA. Biomimetic simulation of tumor-suppressive exosomes shows promising potential as a therapeutic method for sepsis and related conditions.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jianrong Guo, Shoucheng Feng, Hong Liu, Zhuopeng Chen, Chao Ding, Yukai Jin, Xiaojiang Chen, Yudong Ling, Yi Zeng, Hao Long, Haibo Qiu
Summary: This study reveals the association of TRIM6 expression with prognosis in gliomas. TRIM6 promotes the viability, clonogenic potential, migration, and invasion of glioma cells. It is also linked to cytokine-cytokine receptor interaction and the abundance of immune cells.
Article
Zoology
Michal Sulek, Jakub Kordaczuk, Iwona Wojda
Summary: Insect immunity is a complex and interesting field, with recent discoveries shedding light on the adaptive abilities of insects and their immune system plasticity. Immune priming, a phenomenon where insects increase their resistance after encountering pathogens, can occur within individuals or across generations, highlighting the role of parental infection in offspring resistance. Further research is needed to understand the molecular mechanisms and regulatory factors underlying immune priming in insects.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Article
Oncology
Neil E. McCarthy, Andrew J. Stagg, Claire L. Price, Elizabeth R. Mann, Nichola L. Gellatly, Hafid O. Al-Hassi, Stella C. Knight, Nicki Panoskaltsis
Summary: Following infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, patients who developed gastrointestinal symptoms showed dysregulation of the 'gut-homing' pool of blood alpha beta and gamma delta T cells, which could be induced directly by the antibody or the subsequent cytokine storm.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Physiology
Octavio A. C. Talyuli, Vanessa Bottino-Rojas, Carla R. Polycarpo, Pedro L. Oliveira, Gabriela O. Paiva-Silva
Summary: Blood-feeding arthropods are considered a major public health threat due to their role as vectors for a variety of potentially fatal diseases. They acquire pathogens through blood feeding and trigger a series of physiological events critical for their ability to transmit diseases. The physiological changes in insects after a blood meal are crucial for successful infection.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Tetsuya Urasaki, Makiko Ono, Toshiaki Mochizuki, Koichi Takeda, Aya Nishizawa, Eri Fukagawa, Motohiro Fujiwara, Yoshinobu Komai, Shigehisa Kitano, Takeshi Yuasa, Junji Yonese, Shunji Takahashi
Summary: This article reported a rare case of hypotensive shock accompanied by CRS and DiHS induced by ICIs and TMP/SMX treatment. The patient was successfully recovered through various treatments.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Cinzia Signorini, Patrizia Pignatti, Teresa Coccini
Summary: Inflammatory and immune responses play crucial roles in the pathophysiology of COVID-19, leading to a hyper-inflammatory syndrome, while air pollution may partly explain the behavior and progression of the disease. Understanding these mechanisms is important in order to prevent poor prognosis in the late stages of the disease.
Article
Multidisciplinary Sciences
Alyssa W. Kaganer, Robert J. Ossiboff, Nicole I. Keith, Krysten L. Schuler, Pierre Comizzoli, Matthew P. Hare, Robert C. Fleischer, Brian Gratwicke, Elizabeth M. Bunting
Summary: Dynamic interactions between host, pathogen, and host-associated microbiome were investigated in Eastern hellbender salamanders challenged with Batrachochytrium dendrobatidis (Bd). Vaccination did not affect pathogen load, but stimulated different host gene expression depending on the vaccination type. The microbiome was altered by Bd, but anti-Bd microbe abundance or richness did not correlate with pathogen burden. Our findings suggest that the immune response of hellbenders to Bd is initially vigorous but ineffective in controlling disease, and interactions with antifungal skin microbiota do not influence disease progression.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Cell Biology
Tomoe Yashiro, Hanako Ogata, Syed Faisal Zaidi, Jaemin Lee, Shusaku Hayashi, Takeshi Yamamoto, Makoto Kadowaki
Summary: The involvement of enteric neurons in food allergies has been shown to exacerbate the pathology by interacting with mucosal mast cells, suggesting a potential pathological role of IgE-antigen-activated myenteric neurons in food allergies.
Article
Biology
Nicola-Anne J. Rutkowski, Kathryn B. McNamara, Theresa M. Jones, Yong Zhi Foo
Summary: This study conducted a meta-analysis to confirm the occurrence of trans-generational immune priming (TGIP) in invertebrates and found a positive effect size. The strength of the effect was influenced by the immune challenge experienced by the offspring, but not by the ecology or sex of the species. Publication bias testing suggested some level of positive-result bias in the literature.
BIOLOGICAL REVIEWS
(2023)
Article
Immunology
Salah I. Farag, Monika K. Francis, Jyoti M. Gurung, Sun Nyunt Wai, Hans Stenlund, Matthew S. Francis, Aftab Nadeem
Summary: Translocon pores formed by a type III secretion system enable the translocation of effector proteins into host cells. YopD mutants of different classes have varying abilities to alter host cell response and modulation of anti-phagocytosis and programmed cell death pathways.
Article
Immunology
Floriana Mulas, Xu Wang, Shanshan Song, Gopala Nishanth, Wenjing Yi, Anna Brunn, Pia-Katharina Larsen, Berend Isermann, Ulrich Kalinke, Antonio Barragan, Michael Naumann, Martina Deckert, Dirk Schlueter
Summary: OTUB1 is identified as a potent novel regulator of DCs during infectious and inflammatory diseases. It promotes NF-kappa B activity, regulates cytokine production, and impacts the response to pathogens.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Veronica Krenn, Camilla Bosone, Thomas R. Burkard, Julia Spanier, Ulrich Kalinke, Arianna Calistri, Cristiano Salata, Raissa Rilo Christoff, Patricia Pestana Garcez, Ali Mirazimi, Juergen A. Knoblich
Summary: Viral infection in early pregnancy can lead to microcephaly, with distinct mechanisms observed in Zika virus and herpes simplex virus-induced brain organoid models. This study highlights the importance of organoid models in understanding virus-specific mechanisms and immune responses associated with virus-induced microcephaly.
Article
Rheumatology
Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzman, Gerd Sutter, Reinhold E. Schmidt, Torsten Witte, Ulrich Kalinke
Summary: Rituximab-treated patients and B cell-deficient mice showed reduced expansion of virus-specific CD8(+) T cells after vaccination/infection with different vaccines/pathogens, indicating that B cells can modulate CD8(+) T cell responses. The choice of vaccines for B cell-depleted patients needs to be re-evaluated to effectively induce protective CD8(+) T cell responses.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Veronica Duran, Elena Grabski, Constantin Hozsa, Jennifer Becker, Hanzey Yasar, Joao T. Monteiro, Bibiana Costa, Nicole Koller, Yvonne Lueder, Bettina Wiegmann, Gudrun Brandes, Volkhard Kaever, Claus-Michael Lehr, Bernd Lepenies, Robert Tampe, Reinhold Foerster, Berislav Bosnjak, Marcus Furch, Theresa Graalmann, Ulrich Kalinke
Summary: The antibiotic treatment of tuberculosis is complex and lengthy, and can lead to poor patient compliance and the selection of multi-drug resistant bacteria. Encapsulating levofloxacin in lipid nanocarriers functionalized with fucosyl residues has shown to target MMR-positive cells more efficiently, improving the delivery and efficacy of the antibiotic in clearing the pathogen. Carbohydrate-functionalized nanocarriers present a promising tool for enhancing TB treatment by targeted antibiotic delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Neurosciences
Luca Ghita, Veronika Breitkopf, Felix Mulenge, Andreas Pavlou, Olivia Luise Gern, Veronica Duran, Chittappen Kandiyil Prajeeth, Moritz Kohls, Klaus Jung, Martin Stangel, Imke Steffen, Ulrich Kalinke
Summary: In TBEV-infected mice, astrocytes are important producers of IFN-beta, showing biphasic induction that depends on MAVS initially and later on MyD88/TRIF signaling. Astrocytes play a crucial role in early anti-viral responses, while MAVS deficiency negatively affects this response, resulting in increased TBEV replication. Treatment with inhibiting peptides can reduce late IFN-beta responses in WT astrocytes and block entirely IFN-beta responses in MAVS-deficient astrocytes after TBEV exposure.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Immunology
Luca Ghita, Julia Spanier, Chintan Chhatbar, Felix Mulenge, Andreas Pavlou, Pia-Katharina Larsen, Inken Waltl, Yvonne Lueder, Moritz Kohls, Klaus Jung, Sonja M. Best, Reinhold Foerster, Martin Stangel, Dietmar Schreiner, Ulrich Kalinke
Summary: Viral encephalitis triggers a series of immunological events in the brain that can result in brain damage and death. The recruitment of leukocytes into the CNS after neurotropic infection is dependent on MyD88, with infiltrating CD8(+) T cells playing a protective role against lethal CNS VSV infection. Neurons are identified as a critical source of chemokines that regulate leukocyte infiltration in the infected brain and impact survival.
SCIENCE IMMUNOLOGY
(2021)
Article
Virology
Thomas Demoulins, Marie-Laurence Baron, Dominique Gauchat, Nadia Kettaf, Steven James Reed, Tania Charpentier, Ulrich Kalinke, Alain Lamarre, Rafi Ahmed, Rafick-Pierre Sekaly, Surojit Sarkar, Vandana Kalia
Summary: This study found that IFN-I signals mediate thymic atrophy in viral infections, with more severe and prolonged effects in chronic infections compared to acute infections. The loss of thymic output was linked to inhibition of early stages of thymopoiesis and pronounced apoptosis during the late stages. Furthermore, the study revealed both direct and indirect effects of IFN-I on thymocytes, suggesting potential immunotherapeutic strategies targeting IFN-1 signals to manipulate disease outcomes in chronic infections and cancers.
Review
Virology
Olivia Luise Gern, Felix Mulenge, Andreas Pavlou, Luca Ghita, Imke Steffen, Martin Stangel, Ulrich Kalinke
Summary: Viral encephalitis, caused by DNA-encoded and RNA-encoded viruses, is a rare yet serious syndrome. While the role of Toll-like receptors (TLR) during immune stimulation in the periphery is well understood, their functions within the central nervous system remain unclear. The complex interplay between TLR-stimulated neurons, astrocytes, and microglia in conditions of infection requires further investigation to fully understand the functional implications.
Editorial Material
Biochemistry & Molecular Biology
Jennifer Becker, Ulrich Kalinke
Summary: This study investigated the relationship between pDC numbers, IFN-I serum levels, and disease severity in COVID-19 patients, and explored the molecular mechanisms underlying SARS-CoV-2-mediated pDC stimulation to induce cytokine responses.
Article
Biochemistry & Molecular Biology
Lukas Mathias Michaely, Lukas Schuwerk, Lisa Allnoch, Kathleen Schoen, Inken Waltl, Pia-Katharina Larsen, Andreas Pavlou, Chittappen Kandiyil Prajeeth, Guus F. Rimmelzwaan, Stefanie C. Becker, Ulrich Kalinke, Wolfgang Baumgaertner, Ingo Gerhauser
Summary: Rift Valley fever is an emerging disease with zoonotic characteristics. This study investigated the role of immune response in disease progression using an attenuated strain of RVFV. The results showed that IFNAR signaling can prevent systemic spread of the virus, but not its dissemination to the central nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Johannes Schwerk, Lucas Kemper, Kendra A. Bussey, Stefan Lienenklaus, Siegfried Weiss, Luka Cicin-Sain, Andrea Kroeger, Ulrich Kalinke, Christopher M. Collins, Samuel H. Speck, Martin Messerle, Dagmar Wirth, Melanie M. Brinkmann, Hansjoerg Hauser, Mario Koester
Summary: This study investigated the regulation of murine gammaherpesvirus 68 (MHV-68) latency by type I interferon (IFN). The results showed that IFN can control the latency of MHV-68 to a certain extent, but cannot fully prevent viral dissemination during latency. Moreover, impaired IFN signaling in latently infected cells increased the risk of virus reactivation.
Article
Multidisciplinary Sciences
Martina Barends, Nicole Koller, Christian Schoelz, Veronica Duran, Berislav Bosnjak, Jennifer Becker, Marius Doering, Hanna Blees, Reinhold Foerster, Ulrich Kalinke, Robert Tampe
Summary: By studying human dendritic cells, we discovered that additional proteins are recruited to the peptide-loading complex (PLC) during dendritic cell differentiation and maturation, including BAP31, VAPA, and ESYT1. These proteins colocalize with TAP and are in close proximity to the PLC, indicating that the antigen processing machinery is located near ER exit- and membrane contact sites.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Vinzenz Saerchen, Lisa Marie Reindl, Sara Wiedemann, Senthan Shanmugalingam, Thomas Bukur, Julia Becker, Martin Suchan, Evelyn Ullrich, Meike Vogler
Summary: Although pediatric rhabdomyosarcoma (RMS) has shown improved overall survival, the aggressive subtype of alveolar RMS requires new treatment strategies. Researchers found that the use of the Smac mimetic BV6 can sensitize RMS cells to cell death and enhance killing by natural killer (NK) cells. BV6 treatment leads to degradation of inhibitors of apoptosis proteins (IAPs) and activates NF-kappa B signaling pathways in RMS cells. These findings provide insights into the mechanism of BV6 sensitization and suggest potential for combinatory cellular immunotherapy with Smac mimetics.
Article
Neurosciences
Lara-Jasmin Schroeder, Felix Mulenge, Andreas Pavlou, Thomas Skripuletz, Martin Stangel, Viktoria Gudi, Ulrich Kalinke
Summary: In this study, the researchers investigated the transcriptomic signatures of astrocytes during demyelination and remyelination in the cuprizone mouse model. They found that reactive astrocytes showed an inflammatory response during demyelination, while during remyelination, there was a shift towards tissue remodeling and regeneration. These findings highlight the dynamic nature of astrocyte functions during neurodegeneration and regeneration.
Article
Cell Biology
Kunjan Harit, Rituparna Bhattacharjee, Kai Matuschewski, Jennifer Becker, Ulrich Kalinke, Dirk Schlueter, Gopala Nishanth
Summary: This study reveals that the deubiquitinating enzyme OTUD7b prevents TNF-induced apoptosis of dendritic cells (DCs) during infection, resulting in efficient immune response. OTUD7b stabilizes the E3 ligase TNF-receptor-associated factor 2 (TRAF2) by counteracting its K48-ubiquitination, facilitating the activation of NF-κB and MAP kinases, IL-12 production, and expression of anti-apoptotic cFLIP and Bcl-xL. Mice with DC-specific OTUD7b-deficiency showed DC apoptosis and failure to induce CD8(+) T cell-mediated brain pathology in a murine malaria infection model. These findings highlight the importance of OTUD7b as a central molecular switch for DC survival and provide insights for manipulating DC responses.
CELL DEATH & DISEASE
(2023)