Article
Biochemistry & Molecular Biology
Aneta Manda-Handzlik, Agnieszka Mroczek, Weronika Kuzmicka, Adrianna Cieloch, Zuzanna Homoncik, Angelika Muchowicz, Urszula Demkow, Malgorzata Wachowska
Summary: The aim of this study was to investigate the role of p110 delta in neutrophil antimicrobial functions, activation status, and cytokine production. The results showed that p110 delta is not a key player in most neutrophil functions in mice. Further research is recommended to correlate these in vitro results with in vivo observations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Nina Germic, Aref Hosseini, Darko Stojkov, Kevin Oberson, Meike Claus, Charaf Benarafa, Sara Calzavarini, Anne Angelillo-Scherrer, Isabelle C. Arnold, Anne Mueller, Carsten Riether, Shida Yousefi, Hans-Uwe Simon
Summary: The study demonstrates that knocking out Atg5 in eosinophils results in a decrease in mature eosinophils, an increase in immature cells, and affects cell proliferation and differentiation. Additionally, Atg5-deficient eosinophils show enhanced degranulation and bacterial killing abilities, leading to better clearance of bacterial infections in vivo models.
Article
Biochemistry & Molecular Biology
Viviana Mannella, Kira Boehm, Suheyla Celik, Tasnim Ali, Amnah N. Mirza, Mariam El Hasnaouy, Andreas Kaffa, Yanshuang Lyu, Donya Kafaei Golahmadi, Irene M. Leigh, Daniele Bergamaschi, Catherine A. Harwood, Tania Maffucci
Summary: This study identified the potential therapeutic value of several PI3K isoforms in cSCC, showing differential sensitivity of different cell lines to specific PI3K inhibitors. These results may contribute to the development of more targeted therapeutic strategies for cSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
M. G. Filippone, D. Gaglio, R. Bonfanti, F. A. Tucci, E. Ceccacci, R. Pennisi, M. Bonanomi, G. Jodice, M. Tillhon, F. Montani, G. Bertalot, S. Freddi, M. Vecchi, A. Taglialatela, M. Romanenghi, F. Romeo, N. Bianco, E. Munzone, F. Sanguedolce, G. Vago, G. Viale, P. P. Di Fiore, S. Minucci, L. Alberghina, M. Colleoni, P. Veronesi, D. Tosoni, S. Pece
Summary: The overexpression of CDK12 in breast cancer promotes tumorigenesis and makes the cancer cells vulnerable to therapies targeting folate one-carbon metabolism. CDK12 overexpression is associated with early tumor onset and metastasis and is linked to hyperactivation of the serine-glycine-one-carbon network. CDK12-overexpressing breast tumors show positive response to chemotherapy targeting CDK12-induced metabolic alterations, while being refractory to other types of chemotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Luke A. Bourner, Israel Muro, Amy M. Cooper, Barun K. Choudhury, Aaron O. Bailey, William K. Russell, Kamil Khanipov, George Golovko, Casey W. Wright
Summary: Research has shown that the ratio of ARNT isoforms 1:3 in human T cell lymphoma cells determines the regulation of AhR target genes. Modulating this ratio can enhance or abrogate AhR responsiveness, leading to either inflammation or immunosuppression. The phosphorylation of ARNT isoform 1 by CK2 is essential for optimal AhR target gene regulation. These findings highlight the importance of ARNT in modulating AhR activity and suggest potential ARNT-based therapies for immune disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
You -Huang Xiang, Jia-Jun Yu, Ben Liao, Jun -Xiang Shan, Wang-Wei Ye, Nai-Qian Dong, Tao Guo, Yi Kan, Hai Zhang, Yi-Bing Yang, Ya-Chao Li, Huai-Yu Zhao, Hong-Xiao Yu, Zi-Qi Lu, Hong-Xuan Lin
Summary: In this study, a gene locus named STH1 was identified in African rice that is associated with salt tolerance. STH1 regulates fatty acid metabolism and protein degradation, thereby improving rice's salt tolerance and yield. Moreover, STH1 also interacts with other genes to coordinate flowering time and salt stress adaptation. These findings provide new insights into the mechanisms of salt tolerance and plant development, and offer potential strategies for addressing soil salinization challenges.
Article
Immunology
Tyler Brady, Corinne Cayatte, Tiffany L. Roe, Scott D. Speer, Hong Ji, Leeann Machiesky, Tianhui Zhang, Deidre Wilkins, Kevin M. Tuffy, Elizabeth J. Kelly
Summary: Nirsevimab possesses Fc effector activity comparable with the current standard of care, palivizumab. However, despite possessing the capacity for Fc effector activity, data from RSV challenge experiments illustrate that nirsevimab-mediated protection is primarily dependent on direct virus neutralization.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaolin Lu, Liling Chen, Yang Li, Rong Huang, Xiangfeng Meng, Fangfang Sun
Summary: This study reveals that LINC01207 is overexpressed in oral squamous cell carcinoma (OSCC) and promotes OSCC cell proliferation and migration by interacting with microRNA-1301-3p (miR-1301-3p). The effects of LINC01207 downregulation on OSCC cells can be reversed by overexpression of lactate dehydrogenase isoform A (LDHA).
Article
Respiratory System
Xudong Zhang, Mingqiang Zhang, Lun Li, Wei Chen, Wexun Zhou, Jinming Gao
Summary: IRAK-M plays a crucial role in allergic airway inflammation induced by HDM, but does not affect airway hyperreactivity (AHR). Optimal regulation of IRAK-M may present a novel therapeutic avenue for allergic airway inflammation.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Cell Biology
Samira Alliouachene, Benoit Bilanges, Gaetan Chicanne, Karen E. Anderson, Wayne Pearce, Khaled Ali, Colin Valet, York Posor, Pei Ching Low, Claire Chaussade, Cheryl L. Scudamore, Rachel S. Salamon, Jonathan M. Backer, Len Stephens, Phill T. Hawkins, Bernard Payrastre, Bart Vanhaesebroeck
Article
Genetics & Heredity
Julie Guillermet-Guibert, Lee B. Smith, Guillaume Halet, Maria A. Whitehead, Wayne Pearce, Diane Rebourcet, Kelly Leon, Pascale Crepieux, Gemma Nock, Maria Stromstedt, Malin Enerback, Claude Chelala, Mariona Graupera, John Carroll, Sabina Cosulich, Philippa T. K. Saunders, Ilpo Huhtaniemi, Bart Vanhaesebroeck
Article
Endocrinology & Metabolism
Samira Alliouachene, Benoit Bilanges, Claire Chaussade, Wayne Pearce, Lazaros C. Foukas, Cheryl L. Scudamore, Larissa S. Moniz, Bart Vanhaesebroeck
Article
Cell Biology
Sandra D. Castillo, Elena Tzouanacou, May Zaw-Thin, Inma M. Berenjeno, Victoria E. R. Parker, Inigo Chivite, Maria Mila-Guasch, Wayne Pearce, Isabelle Solomon, Ana Angulo-Urarte, Ana M. Figueiredo, Robert E. Dewhurst, Rachel G. Knox, Graeme R. Clark, Cheryl L. Scudamore, Adam Badar, Tammy L. Kalber, Julie Foster, Daniel J. Stuckey, Anna L. David, Wayne A. Phillips, Mark F. Lythgoe, Valerie Wilson, Robert K. Semple, Neil J. Sebire, Veronica A. Kinsler, Mariona Graupera, Bart Vanhaesebroeck
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Multidisciplinary Sciences
Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaetan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Inma M. Berenjeno, Roberto Pineiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck
NATURE COMMUNICATIONS
(2017)
Article
Immunology
Adriana Soler, Helena Serra, Wayne Pearce, Ana Angulo, Julie Guillermet-Guibert, Lori S. Friedman, Francesc Vinals, Holger Gerhardt, Oriol Casanovas, Mariona Graupera, Bart Vanhaesebroeck
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Multidisciplinary Sciences
Khaled Ali, Dalya R. Soond, Roberto Pineiro, Thorsten Hagemann, Wayne Pearce, Ee Lyn Lim, Hicham Bouabe, Cheryl L. Scudamore, Timothy Hancox, Heather Maecker, Lori Friedman, Martin Turner, Klaus Okkenhaug, Bart Vanhaesebroeck
Article
Multidisciplinary Sciences
Junya Mizukami, Takehiro Sato, Montserrat Camps, Hong Ji, Thomas Rueckle, Dominique Swinnen, Ryoji Tsuboi, Kohsuke Takeda, Hidenori Ichijo
SCIENTIFIC REPORTS
(2014)
Article
Immunology
Philipp Haselmayer, Montserrat Camps, Mathilde Muzerelle, Samer El Bawab, Caroline Waltzinger, Lisa Bruns, Nada Abla, Mark A. Polokoff, Carole Jond-Necand, Marilene Gaudet, Audrey Benoit, Dominique Bertschy Meier, Catherine Martin, Denise Gretener, Maria Stella Lombardi, Roland Grenningloh, Christoph Ladel, Jorgen Soberg Petersen, Pascale Gaillard, Hong Ji
FRONTIERS IN IMMUNOLOGY
(2014)
Article
Immunology
Philipp Haselmayer, Montserrat Camps, Lesley Liu-Bujalski, Ngan Nguyen, Federica Morandi, Jared Head, Alison O'Mahony, Simone C. Zimmerli, Lisa Bruns, Andrew T. Bender, Patricia Schroeder, Roland Grenningloh
JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Ralitsa R. Madsen, Rachel G. Knox, Wayne Pearce, Saioa Lopez, Betania Mahler-Araujo, Nicholas McGranahan, Bart Vanhaesebroeck, Robert K. Semple
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Chemistry, Medicinal
Richard D. Caldwell, Hui Qiu, Ben C. Askew, Andrew T. Bender, Nadia Brugger, Montserrat Camps, Mohanraj Dhanabal, Vikram Dutt, Thomas Eichhorn, Anna S. Gardberg, Andreas Goutopoulos, Roland Grenningloh, Jared Head, Brian Healey, Brian L. Hodous, Bayard R. Huck, Theresa L. Johnson, Christopher Jones, Reinaldo C. Jones, Igor Mochalkin, Federica Morandi, Ngan Nguyen, Michael Meyring, Justin R. Potnick, Dusica Cvetinovic Santos, Ralf Schmidt, Brian Sherer, Adam Shutes, Klaus Urbahns, Ariele Viacava Follis, Ansgar A. Wegener, Simone C. Zimmerli, Lesley Liu-Bujalski
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Matt Lechner, Volker H. Schartinger, Christopher D. Steele, Wen Long Nei, Marc Lucas Ooft, Liesa-Marie Schreiber, Christodoulos P. Pipinikas, Grace Tin-Yun Chung, Yuk Yu Chan, Feng Wu, Ka-Fai To, Chi Man Tsang, Wayne Pearce, Daniele Morelli, Martin Philpott, Liam Masterson, Reshma Nibhani, Graham Wells, Christopher G. Bell, Julia Koller, Susanne Delecluse, Yim Ling Yip, Jacklyn Liu, Cillian T. Forde, Martin D. Forster, Amrita Jay, Jozsef Dudas, Annika Krapp, Simon Wan, Christian Uprimny, Susanne Sprung, Johannes Haybaeck, Tim R. Fenton, Kerry Chester, Christina Thirlwell, Gary Royle, Teresa Marafioti, Rajeev Gupta, Sagung Rai Indrasari, Camelia Herdini, Mohd Afiq Mohd Slim, I. Indrawati, Liam Sutton, Renske Fles, Bing Tan, Joe Yeong, Amit Jain, Shuting Han, Haitao Wang, Kelvin S. H. Loke, Wan He, Ruilian Xu, Hongtao Jin, Zhiqiang Cheng, David Howard, Peter H. Hwang, Quynh-Thu Le, Joshua K. Tay, Robert B. West, Sai Wah Tsao, Tim Meyer, Herbert Riechelmann, Udo Oppermann, Henri-Jacques Delecluse, Stefan M. Willems, Melvin L. K. Chua, Pierre Busson, Kwok Wai Lo, Guido Wollmann, Nischalan Pillay, Bart Vanhaesebroeck, Valerie J. Lund
Summary: This study reveals that somatostatin receptor 2 is induced by the Epstein-Barr virus in nasopharyngeal carcinoma and plays a key role in the diagnosis, imaging, targeted therapies, and prognosis of the disease.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Priyanka Tibarewal, Victoria Rathbone, Georgia Constantinou, Wayne Pearce, Mahreen Adil, Zofia Varyova, Lisa Folkes, Alix Hampson, Gala Anastasia Electra Classen, Adriana Alves, Sara Carvalho, Cheryl L. Scudamore, Bart Vanhaesebroeck
Summary: PTEN is an important tumor suppressor gene in cancer, and its deregulation can lead to various cancers. In this study, the authors investigated the potential of the PI3K/mTOR pathway inhibitor rapamycin in preventing cancer in a mouse model of PTEN hamartoma tumor syndrome (PHTS). They found that long-term treatment with low-dose rapamycin significantly improved survival and delayed the development of certain tumors in mice with heterozygous germline Pten loss. This suggests that rapamycin may have cancer prevention potential in human PHTS and other cancers with PI3K pathway activation.
JOURNAL OF PATHOLOGY
(2022)