Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent

Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition

(2014) Paul J. M. Jackson et al.   ACS Chemical Biology

GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models

(2013) Khondaker M. Rahman et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Extended Pyrrolobenzodiazepine–Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site

(2013) Federico Brucoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolo[2,1-c][1,4]benzodiazepine as a Scaffold for the Design and Synthesis of Anti- Tumour Drugs

(2012) Laura Cipolla et al.   Anti-Cancer Agents in Medicinal Chemistry

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates

(2012) Khondaker M. Rahman et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057

(2011) John A. Hartley et al.   INVESTIGATIONAL NEW DRUGS

The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus

(2011) Helena Rosado et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Observation of a Single-Stranded DNA/Pyrrolobenzodiazepine Adduct

(2011) Khondaker M. Rahman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers

(2011) Khondaker M. Rahman et al.   NUCLEIC ACIDS RESEARCH

Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy

(2011) Khondaker M. Rahman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling

(2011) Ming-Chu Hsieh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

(2010) Dyeison Antonow et al.   CHEMICAL REVIEWS

DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents

(2010) Khondaker M. Rahman et al.   ACS Medicinal Chemistry Letters

Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential

(2009) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors

(2009) Yelena Y. Janjigian et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Phase I Study of Sequence-Selective Minor Groove DNA Binding Agent SJG-136 in Patients with Advanced Solid Tumors

(2009) D. Hochhauser et al.   CLINICAL CANCER RESEARCH

Fanconi Anemia Proteins, DNA Interstrand Crosslink Repair Pathways, and Cancer Therapy

(2009) Paul Andreassen et al.   CURRENT CANCER DRUG TARGETS

Limazepines A−F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.

(2009) Serge Fotso et al.   JOURNAL OF NATURAL PRODUCTS

The Effects of Hairpin Loops on Ligand−DNA Interactions

(2009) Binh Nguyen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links

(2009) Khondaker M. Rahman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization

(2008) Geoffrey Wells et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78

(2008) M. Kotecha et al.   MOLECULAR CANCER THERAPEUTICS

An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences

(2007) Mathangi Narayanaswamy et al.   ANALYTICAL BIOCHEMISTRY