Molecular pathogenesis of intrahepatic cholangiocarcinoma

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Activating Mutations in PTPN3 Promote Cholangiocarcinoma Cell Proliferation and Migration and Are Associated With Tumor Recurrence in Patients

(2014) Qiang Gao et al.   GASTROENTEROLOGY

Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma

(2014) Rondell P. Graham et al.   HUMAN PATHOLOGY

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

(2014) John Bridgewater et al.   JOURNAL OF HEPATOLOGY

New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation Sequencing

(2014) J. S. Ross et al.   ONCOLOGIST

Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

(2014) Mitesh J. Borad et al.   PLoS Genetics

Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma

(2014) Michael N. Mavros et al.   JAMA Surgery

Asbestos: a hidden player behind the cholangiocarcinoma increase? Findings from a case–control analysis

(2013) Giovanni Brandi et al.   CANCER CAUSES & CONTROL

A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas

(2013) Steffen Zender et al.   CANCER CELL

Aberrant DNA Methylation at Genes Associated with a Stem Cell-like Phenotype in Cholangiocarcinoma Tumors

(2013) R. Sriraksa et al.   Cancer Prevention Research

Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma

(2013) R. V. Guest et al.   CANCER RESEARCH

miR-204 Inhibits Epithelial to Mesenchymal Transition by Targeting Slug in Intrahepatic Cholangiocarcinoma Cells

(2013) Ying-he Qiu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Genomic Decoding of Intrahepatic Cholangiocarcinoma Reveals Therapeutic Opportunities

(2013) Jesper B. Andersen et al.   GASTROENTEROLOGY

Modeling Pathogenesis of Primary Liver Cancer in Lineage-Specific Mouse Cell Types

(2013) Ágnes Holczbauer et al.   GASTROENTEROLOGY

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma

(2013) Christian D. Fingas et al.   HEPATOLOGY

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway

(2013) Benjamin Goeppert et al.   HEPATOLOGY

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

(2013) Guanhua Xie et al.   HEPATOLOGY

Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma

(2013) Laurent Sulpice et al.   HEPATOLOGY

Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

(2013) Yasuhito Arai et al.   HEPATOLOGY

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

(2013) Waraporn Chan-on et al.   NATURE GENETICS

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

(2013) Yuchen Jiao et al.   NATURE GENETICS

Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane

(2013) Shinji Kumagai et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies

(2013) D Sia et al.   ONCOGENE

Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target

(2013) A. Saborowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

(2013) Yi-Mi Wu et al.   Cancer Discovery

KrasG12D and p53 Mutation Cause Primary Intrahepatic Cholangiocarcinoma

(2012) M. R. O'Dell et al.   CANCER RESEARCH

Classification, Diagnosis, and Management of Cholangiocarcinoma

(2012) Nataliya Razumilava et al.   Clinical Gastroenterology and Hepatology

Genetic profiling of intrahepatic cholangiocarcinoma

(2012) Jesper B. Andersen et al.   CURRENT OPINION IN GASTROENTEROLOGY

Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist

(2012) Bin Li et al.   FEBS Journal

MicroRNAs in Liver Disease

(2012) Xin Wei Wang et al.   GASTROENTEROLOGY

Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update

(2012) Shahid A Khan et al.   GUT

Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma

(2012) Naoki Oishi et al.   HEPATOLOGY

A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition

(2012) Jae Yeon Seok et al.   HEPATOLOGY

Constitutive Notch2 signaling induces hepatic tumors in mice

(2012) Michael T. Dill et al.   HEPATOLOGY

Activated hepatic stellate cells mediate the differentiation of macrophages

(2012) Jonathan Chang et al.   HEPATOLOGY RESEARCH

Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma

(2012) Benjamin R. Kipp et al.   HUMAN PATHOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative Genomic Analysis of Primary Versus Metastatic Colorectal Carcinomas

(2012) Efsevia Vakiani et al.   JOURNAL OF CLINICAL ONCOLOGY

Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma

(2012) William C. Palmer et al.   JOURNAL OF HEPATOLOGY

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Exome sequencing of liver fluke–associated cholangiocarcinoma

(2012) Choon Kiat Ong et al.   NATURE GENETICS

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

(2012) P Wang et al.   ONCOGENE

Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats

(2012) Yixiong Chen et al.   PLoS One

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

The Hippo signaling pathway and stem cell biology

(2012) Azucena Ramos et al.   TRENDS IN CELL BIOLOGY

Desmoplasia: A Response or a Niche?

(2012) Yves A. DeClerck   Cancer Discovery

Effects of mTOR Inhibitors on Components of the Salvador-Warts-Hippo Pathway

(2012) Jonathan Chiang et al.   Cells

Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity

(2012) Vincenzo Cardinale   World Journal of Gastrointestinal Oncology

CpG-island methylation study of liver fluke-related cholangiocarcinoma

(2011) R Sriraksa et al.   BRITISH JOURNAL OF CANCER

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells

(2011) Christian D. Fingas et al.   HEPATOLOGY

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

(2011) D. R. Borger et al.   ONCOLOGIST

RNA-Seq Analyses Generate Comprehensive Transcriptomic Landscape and Reveal Complex Transcript Patterns in Hepatocellular Carcinoma

(2011) Qichao Huang et al.   PLoS One

Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers

(2011) L. G. T. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiological trends in incidence and mortality of hepatobiliary cancers in Germany

(2011) Thomas von Hahn et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Array comparative genomic hybridization identifies novel potential therapeutic targets in cholangiocarcinoma

(2011) Siobhan C. McKay et al.   HPB

Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?

(2011) Mia Kumar et al.   Cell and Bioscience

KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients

(2010) Rui Feng Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

(2010) J Avruch et al.   BRITISH JOURNAL OF CANCER

The clinical potential of microRNAs

(2010) Anuradha Budhu et al.   Journal of Hematology & Oncology

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

(2010) A Scuto et al.   LEUKEMIA

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer

(2010) Juan Valle et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic and Epigenomic Approach Predicts Therapeutic Response to Zebularine in Human Liver Cancer

(2010) J. B. Andersen et al.   Science Translational Medicine

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

(2009) Steve S. Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Burden of Digestive Diseases in the United States Part III: Liver, Biliary Tract, and Pancreas

(2009) James E. Everhart et al.   GASTROENTEROLOGY

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

(2009) Florin M. Selaru et al.   HEPATOLOGY

Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties

(2009) C Coulouarn et al.   ONCOGENE

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

(2009) P. Schoffski   ONCOLOGIST

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

MicroRNA Profiling of Human Intrahepatic Cholangiocarcinoma Cell Lines Reveals Biliary Epithelial Cell-specific MicroRNAs

(2009) Yutaka Kawahigashi et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Gene Expression-Based Recurrence Prediction of Hepatitis B Virus-Related Human Hepatocellular Carcinoma

(2008) H. G. Woo et al.   CLINICAL CANCER RESEARCH

RarePIK3CA hotspot mutations in carcinomas of the biliary tract

(2008) Marc-Oliver Riener et al.   GENES CHROMOSOMES & CANCER

The hedgehog pathway regulates remodelling responses to biliary obstruction in rats

(2008) A Omenetti et al.   GUT

The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma

(2008) Lei Chen et al.   JOURNAL OF HEPATOLOGY

Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma

(2008) Alphonse E Sirica   WORLD JOURNAL OF GASTROENTEROLOGY