Better together: the role of IFIT protein–protein interactions in the antiviral response

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

(2018) Britney Johnson et al.   IMMUNITY

IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA

(2018) Renata C Fleith et al.   NUCLEIC ACIDS RESEARCH

Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection

(2018) Marcin Stawowczyk et al.   mBio

Chicken Interferon-induced Protein with Tetratricopeptide Repeats 5 Antagonizes Replication of RNA Viruses

(2018) Diwakar Santhakumar et al.   Scientific Reports

Elevated IFIT3 Contributes to Abnormal Overactive cGAS-STING Signaling in Human Systemic Lupus Erythematosus Monocytes

(2018) Jiehua Wang et al.   Arthritis & Rheumatology

Genotypes of IFIH1 and IFIT5 in seven chicken breeds indicated artificial selection for commercial traits influenced antiviral genes

(2017) Jing-Jing Li et al.   INFECTION GENETICS AND EVOLUTION

Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis

(2017) Limin Chen et al.   International Journal of Biological Sciences

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

(2017) Yazan M. Abbas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axis

(2017) Wei-Guo Tang et al.   Oncotarget

Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells

(2017) Tomoyuki Ohsugi et al.   Oncotarget

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

(2017) Vineet D. Menachery et al.   mSphere

Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis

(2016) Yuan Wang et al.   CANCER LETTERS

Antiviral effects of IFIT1 in human cytomegalovirus-infected fetal astrocytes

(2016) Li Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family

(2016) D. F. Young et al.   JOURNAL OF VIROLOGY

Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3

(2016) M. A. G. Rabbani et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity

(2016) Zhangtao Jiang et al.   JOURNAL OF VIROLOGY

The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network

(2016) H Jia et al.   ONCOGENE

Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-κB

(2016) Dong Li et al.   Oncotarget

Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a

(2016) Zhaohua Hou et al.   Scientific Reports

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

(2016) Matthew D Daugherty et al.   eLife

IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)

(2015) Caishang Zheng et al.   CELLULAR SIGNALLING

Inferring Genome-Wide Functional Modulatory Network: A Case Study on NF-κB/RelA Transcription Factor

(2015) Xueling Li et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families

(2015) Amelia K. Pinto et al.   JOURNAL OF VIROLOGY

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

(2015) Josephine M. Reynaud et al.   PLoS Pathogens

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

(2015) Giselle A. Funchal et al.   PLoS One

MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2

(2014) Xiaoshan Feng et al.   BMC CANCER

Inhibition of Reactive Oxygen Species Production Ameliorates Inflammation Induced by Influenza A Viruses via Upregulation of SOCS1 and SOCS3

(2014) Siying Ye et al.   JOURNAL OF VIROLOGY

Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2'-O-Methyltransferase Activity

(2014) V. D. Menachery et al.   JOURNAL OF VIROLOGY

Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis

(2014) Volker Fensterl et al.   JOURNAL OF VIROLOGY

A Viral RNA Structural Element Alters Host Recognition of Nonself RNA

(2014) J. L. Hyde et al.   SCIENCE

IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways

(2013) B. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Molecular Basis of NF-κB Signaling

(2013) Johanna Napetschnig et al.   Annual Review of Biophysics

Crystal structure and nucleotide selectivity of human IFIT5/ISG58

(2013) Feng Feng et al.   CELL RESEARCH

Defense genes missing from the flight division

(2013) Katharine E. Magor et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Interferon Induced IFIT Family Genes in Host Antiviral Defense

(2013) Xiang Zhou et al.   International Journal of Biological Sciences

Jun Activation Domain-binding Protein 1 (JAB1) Is Required for the Optimal Response to Interferons

(2013) Ryuta Muromoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFIT2 Is an Effector Protein of Type I IFN-Mediated Amplification of Lipopolysaccharide (LPS)-Induced TNF-  Secretion and LPS-Induced Endotoxin Shock

(2013) A. Siegfried et al.   JOURNAL OF IMMUNOLOGY

A Role for Ifit2 in Restricting West Nile Virus Infection in the Brain

(2013) H. Cho et al.   JOURNAL OF VIROLOGY

Ifit1 Inhibits Japanese Encephalitis Virus Replication through Binding to 5' Capped 2'-O Unmethylated RNA

(2013) T. Kimura et al.   JOURNAL OF VIROLOGY

Rational Design of a Flavivirus Vaccine by Abolishing Viral RNA 2'-O Methylation

(2013) S.-H. Li et al.   JOURNAL OF VIROLOGY

tRNA Binding, Structure, and Localization of the Human Interferon-Induced Protein IFIT5

(2013) George E. Katibah et al.   MOLECULAR CELL

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

(2013) Yazan M. Abbas et al.   NATURE

Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family

(2013) Ying Liu et al.   PLoS One

Protective Roles of Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) in Dengue Virus Infection of Human Lung Epithelial Cells

(2013) Yu-Lin Hsu et al.   PLoS One

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

(2013) Roland Züst et al.   PLoS Pathogens

Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms

(2012) Zhenlin Yang et al.   CELL RESEARCH

ISG56/IFIT1 is primarily responsible for interferon-induced changes to patterns of parainfluenza virus type 5 transcription and protein synthesis

(2012) J. Andrejeva et al.   JOURNAL OF GENERAL VIROLOGY

Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells

(2012) K C Lai et al.   ONCOGENE

Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis

(2012) Volker Fensterl et al.   PLoS Pathogens

2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo

(2012) Kristy J. Szretter et al.   PLoS Pathogens

Inhibitor of κB Kinase ϵ (IKKϵ), STAT1, and IFIT2 Proteins Define Novel Innate Immune Effector Pathway against West Nile Virus Infection

(2011) Olivia Perwitasari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1

(2011) X.-Y. Liu et al.   JOURNAL OF IMMUNOLOGY

ISG56 and IFITM1 Proteins Inhibit Hepatitis C Virus Replication

(2011) A. Raychoudhuri et al.   JOURNAL OF VIROLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

The Interferon Stimulated Gene 54 Promotes Apoptosis

(2010) Marcin Stawowczyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ISG56/IFIT1 Gene Family

(2010) Volker Fensterl et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Inhibitory Action of P56 on Select Functions of E1 Mediates Interferon's Effect on Human Papillomavirus DNA Replication

(2010) P. Saikia et al.   JOURNAL OF VIROLOGY

Identification of Alpha Interferon-Induced Genes Associated with Antiviral Activity in Daudi Cells and Characterization of IFIT3 as a Novel Antiviral Gene

(2010) H. Schmeisser et al.   JOURNAL OF VIROLOGY

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forced IFIT-2 expression represses LPS induced TNF-alpha expression at posttranscriptional levels

(2008) Susanne Berchtold et al.   BMC IMMUNOLOGY

Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1

(2008) Fulvia Terenzi et al.   EMBO JOURNAL

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells

(2008) Xiangyang Huang et al.   ARTHRITIS RESEARCH & THERAPY