Jun Activation Domain-binding Protein 1 (JAB1) Is Required for the Optimal Response to Interferons

Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924

(2012) J. L. Blank et al.   CANCER RESEARCH

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Type I IFN receptor controls activated TYK2 in the nucleus: Implications for EAE therapy

(2012) Chulbul M. Ahmed et al.   JOURNAL OF NEUROIMMUNOLOGY

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

(2011) M. A. Milhollen et al.   CANCER RESEARCH

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

(2010) J. J. Lin et al.   CANCER RESEARCH

Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy

(2009) Claire Pearce et al.   BMC CELL BIOLOGY

Virus-Induced Unfolded Protein Response Attenuates Antiviral Defenses via Phosphorylation-Dependent Degradation of the Type I Interferon Receptor

(2009) Jianghuai Liu et al.   Cell Host & Microbe

Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer

(2009) T. A. Soucy et al.   CLINICAL CANCER RESEARCH

COP9 signalosome controls the Carma1–Bcl10–Malt1 complex upon T-cell stimulation

(2009) Verena Welteke et al.   EMBO REPORTS

Inducible Priming Phosphorylation Promotes Ligand-independent Degradation of the IFNAR1 Chain of Type I Interferon Receptor

(2009) Sabyasachi Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

(2009) Rinki Minakshi et al.   PLoS One

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements

(2008) Ya-Lin Chiu et al.   Annual Review of Immunology

Ligand-independent pathway that controls stability of interferon alpha receptor

(2008) Jianghuai Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Basal Ubiquitin-independent Internalization of Interferon α Receptor Is Prevented by Tyk2-mediated Masking of a Linear Endocytic Motif

(2008) K. G. Suresh Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

The COP9 signalosome: more than a protease

(2008) N WEI et al.   TRENDS IN BIOCHEMICAL SCIENCES