Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits

Cross-linking of Orai1 channels by STIM proteins

(2018) Yandong Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm

(2018) Nupura Hirve et al.   Cell Reports

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

(2017) Megumi Yamashita et al.   Nature Communications

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

(2017) Martin Vaeth et al.   Nature Communications

Sequential Steps of CRAC Channel Activation

(2017) Raz Palty et al.   Cell Reports

Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel

(2016) Michelle Yen et al.   BIOPHYSICAL JOURNAL

The Orai1 Store-operated Calcium Channel Functions as a Hexamer

(2016) Xiangyu Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orai1 pore residues control CRAC channel inactivation independently of calmodulin

(2016) Franklin M. Mullins et al.   JOURNAL OF GENERAL PHYSIOLOGY

The STIM1-binding site nexus remotely controls Orai1 channel gating

(2016) Yandong Zhou et al.   Nature Communications

Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating

(2015) Raz Palty et al.   CELL RESEARCH

Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1)

(2015) Raz Palty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

(2015) Anshul Rana et al.   JOURNAL OF CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

(2015) Yandong Zhou et al.   Nature Communications

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding

(2015) Leidamarie Tirado-Lee et al.   PLoS One

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

Gated regulation of CRAC channel ion selectivity by STIM1

(2012) Beth A. McNally et al.   NATURE

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

Stoichiometric requirements for trapping and gating of Ca2+release-activated Ca2+(CRAC) channels by stromal interaction molecule 1 (STIM1)

(2011) Paul J. Hoover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

(2010) Zhengzheng Li et al.   CELL RESEARCH

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

(2009) N. Scrimgeour et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

How to Validate a Heteromeric Ion Channel Drug Target: Assessing Proper Expression of Concatenated Subunits: Figure 1.

(2008) Jon T. Sack et al.   JOURNAL OF GENERAL PHYSIOLOGY

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE