Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility

Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation

(2010) J. F. JOHANSON et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine

(2010) Robert L. Jakab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Use of the Chloride Channel Activator Lubiprostone for Constipation in Adults with Cystic Fibrosis: A Case Series

(2010) Catherine E O'Brien et al.   ANNALS OF PHARMACOTHERAPY

Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype

(2010) Robert C De Lisle et al.   BMC GASTROENTEROLOGY

Lubiprostone Activates Cl− Secretion via cAMP Signaling and Increases Membrane CFTR in the Human Colon Carcinoma Cell Line, T84

(2010) Mei Ao et al.   DIGESTIVE DISEASES AND SCIENCES

Lubiprostone Reverses the Inhibitory Action of Morphine on Mucosal Secretion in Human Small Intestine

(2010) Xiaohong Sun et al.   DIGESTIVE DISEASES AND SCIENCES

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon

(2010) Kuai Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon

(2009) Guijun Fei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans

(2009) N. S. Joo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Unpacking a gel-forming mucin: a view of MUC5B organization after granular release

(2009) Mehmet Kesimer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lubiprostone Stimulates Duodenal Bicarbonate Secretion in Rats

(2009) Misa Mizumori et al.   DIGESTIVE DISEASES AND SCIENCES

Activation of Intestinal Cl− Secretion by Lubiprostone Requires the Cystic Fibrosis Transmembrane Conductance Regulator

(2009) Marcel J.C. Bijvelds et al.   GASTROENTEROLOGY

Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator–dependent bicarbonate secretion

(2009) Mary Abigail S. Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome - results of two randomized, placebo-controlled studies

(2008) D. A. DROSSMAN et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A synthetic prostone activates apical chloride channels in A6 epithelial cells

(2008) Hui Fang Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects

(2008) Seth Sweetser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon

(2008) A K Bassil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Down-regulated in Adenoma Cl/HCO3 Exchanger Couples With Na/H Exchanger 3 for NaCl Absorption in Murine Small Intestine

(2008) Nancy M. Walker et al.   GASTROENTEROLOGY