Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

(2011) Laura M. Fahey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma

(2010) Atsushi Moriwaki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut

(2010) Keiichiro Suzuki et al.   IMMUNITY

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

(2010) Elissa K. Deenick et al.   IMMUNITY

HIV-Specific IL-21 Producing CD4+ T Cells Are Induced in Acute and Chronic Progressive HIV Infection and Are Associated with Relative Viral Control

(2010) F. Y. Yue et al.   JOURNAL OF IMMUNOLOGY

Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor

(2010) M. M. McFarland-Mancini et al.   JOURNAL OF IMMUNOLOGY

In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development

(2010) A. C. Poholek et al.   JOURNAL OF IMMUNOLOGY

HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function

(2010) M. F. Chevalier et al.   JOURNAL OF VIROLOGY

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation

(2009) Yongzhong Wu et al.   INTERNATIONAL IMMUNOLOGY

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+T cells

(2009) Oliver Dienz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired Plasmacytoid Dendritic Cell (PDC)-NK Cell Activity in Viremic Human Immunodeficiency Virus Infection Attributable to Impairments in both PDC and NK Cell Function

(2009) S. J. Conry et al.   JOURNAL OF VIROLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

Impaired Antibody Response Causes Persistence of Prototypic T Cell–Contained Virus

(2009) Andreas Bergthaler et al.   PLOS BIOLOGY

Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections

(2008) Elina I. Zuniga et al.   Cell Host & Microbe

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

Development and characterization of IL-21–producing CD4+T cells

(2008) Akira Suto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

(2008) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

(2008) Christopher D.C. Allen et al.   SEMINARS IN IMMUNOLOGY