Opposing role of Notch1 and Notch2 in a KrasG12D-driven murine non-small cell lung cancer model

Notching up a new therapeutic strategy for Non-Small Cell Lung Carcinoma (NSCLC)

(2015) Antonio Maraver et al.   Oncotarget

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal

(2013) Yanyan Zheng et al.   CANCER CELL

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK

(2012) Antonio Maraver et al.   CANCER CELL

The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index

(2012) J. Slotta-Huspenina et al.   HAEMATOLOGICA

Epidermal growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas: loss of PTEN is associated with worse clinical outcome

(2012) Marcus Bettstetter et al.   HUMAN PATHOLOGY

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma

(2011) T. D. Allen et al.   CANCER RESEARCH

Complex interplay between  -catenin signalling and Notch effectors in intestinal tumorigenesis

(2011) G. Peignon et al.   GUT

Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium

(2011) Eugenia C. Pacheco-Pinedo et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch Signaling Contributes to Lung Cancer Clonogenic Capacity In Vitro but May Be Circumvented in Tumorigenesis In Vivo

(2011) J. Osanyingbemi-Obidi et al.   MOLECULAR CANCER RESEARCH

The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma

(2011) Chanh Huynh et al.   PLoS One

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

(2010) Linda Hanlon et al.   CANCER RESEARCH

ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non-Small Cell Lung Cancer

(2010) A. Baumgart et al.   CANCER RESEARCH

Selective activation of p53-mediated tumour suppression in high-grade tumours

(2010) Melissa R. Junttila et al.   NATURE

Stage-specific sensitivity to p53 restoration during lung cancer progression

(2010) David M. Feldser et al.   NATURE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway

(2010) S Eliasz et al.   ONCOGENE

E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases

(2010) L Asnaghi et al.   ONCOGENE

Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine KrasG12D-Induced Skin Carcinogenesis In Vivo

(2010) Pawel K. Mazur et al.   PLoS One

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

(2010) P. K. Mazur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch2 Expression Is Decreased in Colorectal Cancer and Related to Tumor Differentiation Status

(2009) Dake Chu et al.   ANNALS OF SURGICAL ONCOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

(2009) Johannes von Burstin et al.   GASTROENTEROLOGY

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunohistochemical markers associated with brain metastases in patients with nonsmall cell lung carcinoma

(2008) Ali G. Saad et al.   CANCER

Opposite Effects of Notch-1 and Notch-2 on Mesothelioma Cell Survival under Hypoxia Are Exerted through the Akt Pathway

(2008) I. Graziani et al.   CANCER RESEARCH

Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

(2008) Jonas Sjölund et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncogenic K-Ras Regulates Proliferation and Cell Junctions in Lung Epithelial Cells through Induction of Cyclooxygenase-2 and Activation of Metalloproteinase-9

(2008) Xue-Qing Wang et al.   MOLECULAR BIOLOGY OF THE CELL