Gastric cancer and gene copy number variation: emerging cancer drivers for targeted therapy
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Title
Gastric cancer and gene copy number variation: emerging cancer drivers for targeted therapy
Authors
Keywords
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Journal
ONCOGENE
Volume 35, Issue 12, Pages 1475-1482
Publisher
Springer Nature
Online
2015-06-15
DOI
10.1038/onc.2015.209
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Note: Only part of the references are listed.- Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer
- (2015) Phillip Stahl et al. BMC GASTROENTEROLOGY
- Global cancer statistics, 2012
- (2015) Lindsey A. Torre et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Cancer statistics, 2015
- (2015) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Frequent involvement of chromatin remodeler alterations in gastric field cancerization
- (2015) Hideyuki Takeshima et al. CANCER LETTERS
- Copy number loss or silencing of apoptosis-effector genes in cancer
- (2015) James A. Mauro et al. GENE
- Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma
- (2015) Liwen Hu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Targeting mitochondria metabolism for cancer therapy
- (2015) Samuel E Weinberg et al. Nature Chemical Biology
- Mutational landscape of gastric adenocarcinoma in Chinese: Implications for prognosis and therapy
- (2015) Kexin Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-invasive Analysis of Genomic Copy Number Variation in Patients with Hepatocellular Carcinoma by Next Generation DNA Sequencing
- (2015) Hongtao Xu et al. Journal of Cancer
- Recent advances in the HER2 targeted therapy of gastric cancer
- (2015) Tasuku Matsuoka World Journal of Clinical Cases
- MET amplification as a potential therapeutic target in gastric cancer
- (2015) Hisato Kawakami et al. Oncotarget
- Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer
- (2015) Jinjia Chang et al. Oncotarget
- Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma
- (2014) Rui M. Ferreira et al. BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
- Chromosomal alterations in exfoliated urothelial cells from bladder cancer cases and healthy men: a prospective screening study
- (2014) Nadine Bonberg et al. BMC CANCER
- Circulating Mitochondrial DNA Level, a Noninvasive Biomarker for the Early Detection of Gastric Cancer
- (2014) J. Fernandes et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Mutually exclusive FGFR2, HER2, and KRAS gene amplifications in gastric cancer revealed by multicolour FISH
- (2014) Kakoli Das et al. CANCER LETTERS
- Long Noncoding RNA GAPLINC Regulates CD44-Dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer
- (2014) Y. Hu et al. CANCER RESEARCH
- Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis
- (2014) Masanori Hatakeyama Cell Host & Microbe
- Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer
- (2014) Yukie Yoda et al. Gastric Cancer
- The effect of Helicobacter pylori CagA on the HER-2 copy number and expression in gastric cancer
- (2014) Jung Ho Shim et al. GENE
- Whole genome gene copy number profiling of gastric cancer identifiesPAK1andKRASgene amplification as therapy targets
- (2014) Ziliang Qian et al. GENES CHROMOSOMES & CANCER
- Somatic copy number alterations predict response to platinum therapy in epithelial ovarian cancer
- (2014) Evelyn Despierre et al. GYNECOLOGIC ONCOLOGY
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis
- (2014) Sukanya Horpaopan et al. INTERNATIONAL JOURNAL OF CANCER
- The role of miR-148a in gastric cancer
- (2014) Jiazeng Xia et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The prognostic significance of the prognostic nutritional index in cancer: a systematic review and meta-analysis
- (2014) Kaiyu Sun et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Metagenome of Mehsani Buffalo Rumen Microbiota: An Assessment of Variation in Feed-Dependent Phylogenetic and Functional Classification
- (2014) Nidhi R. Parmar et al. JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY
- Xenophagy inHelicobacter pylori- and Epstein-Barr virus-induced gastric cancer
- (2014) Lin Zhang et al. JOURNAL OF PATHOLOGY
- Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models
- (2014) Paul R. Gavine et al. Molecular Oncology
- AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers
- (2014) Ahmed Katsha et al. Molecular Oncology
- Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
- (2014) Kai Wang et al. NATURE GENETICS
- Genomic screening of testicular germ cell tumors from monozygotic twins
- (2014) Sara Martoreli Silveira et al. Orphanet Journal of Rare Diseases
- Clinical epidemiology of gastric cancer
- (2014) TL Ang et al. SINGAPORE MEDICAL JOURNAL
- Detection of kinase amplifications in gastric adenocarcinomas
- (2014) Muhsin ÖZDEMİR et al. Turkish Journal Of Medical Sciences
- Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression
- (2014) Hsin-Chen Lee WORLD JOURNAL OF GASTROENTEROLOGY
- Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity
- (2014) J Xu et al. Cell Death & Disease
- ArhGAP30 promotes p53 acetylation and function in colorectal cancer
- (2014) Jilin Wang et al. Nature Communications
- The role of epidermal growth factor receptor in prognosis and treatment of gastric cancer
- (2014) Liu Hong et al. Expert Review of Gastroenterology & Hepatology
- DawnRank: discovering personalized driver genes in cancer
- (2014) Jack P Hou et al. Genome Medicine
- HER2 status in gastric cancers: a retrospective analysis from four Chinese representative clinical centers and assessment of its prognostic significance
- (2013) W. Q. Sheng et al. ANNALS OF ONCOLOGY
- Genetic lineages of undifferentiated-type gastric carcinomas analysed by unsupervised clustering of genomic DNA microarray data
- (2013) Ayano Sonoda et al. BMC Medical Genomics
- METamplification is not rare and predicts unfavorable clinical outcomes in patients with recurrent/metastatic gastric cancer after chemotherapy
- (2013) Xin An et al. CANCER
- FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547
- (2013) L. Xie et al. CLINICAL CANCER RESEARCH
- High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers
- (2013) Matteo Fassan et al. Gastric Cancer
- Prognostic implications of EGFR and HER-2 alteration assessed by immunohistochemistry and silver in situ hybridization in gastric cancer patients following curative resection
- (2013) Ho Suk Oh et al. Gastric Cancer
- Aurora Kinase A Promotes Inflammation and Tumorigenesis in Mice and Human Gastric Neoplasia
- (2013) Ahmed Katsha et al. GASTROENTEROLOGY
- Prognostic value of epidermal growth factor receptor in patients with gastric cancer: A meta-analysis
- (2013) Liu Hong et al. GENE
- Molecular Pathogenesis of Gastric Cancer
- (2013) Ceu Figueiredo et al. HELICOBACTER
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- (2013) Juan An et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- TNK2gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer
- (2013) Kazuya Shinmura et al. JOURNAL OF SURGICAL ONCOLOGY
- Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial
- (2013) Tom Waddell et al. LANCET ONCOLOGY
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- (2013) Florian Lordick et al. LANCET ONCOLOGY
- MET overexpression assessed by new interpretation method predicts gene amplification and poor survival in advanced gastric carcinomas
- (2013) Sang Y Ha et al. MODERN PATHOLOGY
- The OCT4 pseudogene POU5F1B is amplified and promotes an aggressive phenotype in gastric cancer
- (2013) H Hayashi et al. ONCOGENE
- MYC Deregulation in Gastric Cancer and Its Clinicopathological Implications
- (2013) Carolina Rosal Teixeira de Souza et al. PLoS One
- Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy
- (2013) W. W. Hwang-Verslues et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlation of human epidermal growth factor receptor 2 expression with clinicopathological characteristics and prognosis in gastric cancer
- (2013) Chao He WORLD JOURNAL OF GASTROENTEROLOGY
- High-level copy number gains of established and potential drug target genes in gastric cancer as a lead for treatment development and selection
- (2013) Mariette Labots et al. CELLULAR ONCOLOGY
- A clinical–biological risk stratification model for resected gastric cancer: prognostic impact of Her2, Fhit, and APC expression status
- (2012) E. Bria et al. ANNALS OF ONCOLOGY
- Integrating Bioinformatics and Clinicopathological Research of Gastrointestinal Stromal Tumors: Identification of Aurora Kinase A as a Poor Risk Marker
- (2012) Chueh-Chuan Yen et al. ANNALS OF SURGICAL ONCOLOGY
- Progress in cancer therapy targeting c-Met signaling pathway
- (2012) Kyung Hee Jung et al. ARCHIVES OF PHARMACAL RESEARCH
- Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer
- (2012) Jing Shi et al. BMC CANCER
- hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions
- (2012) Tanielly Cristina Raiol Silva et al. BMC GASTROENTEROLOGY
- Identification of genes with a correlation between copy number and expression in gastric cancer
- (2012) Lei Cheng et al. BMC Medical Genomics
- FGFR2 gene amplification and clinicopathological features in gastric cancer
- (2012) K Matsumoto et al. BRITISH JOURNAL OF CANCER
- APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression
- (2012) Zhengyu Fang et al. Clinical & Translational Oncology
- Targeting the EGFR-family for Therapy: Biological Challenges and Clinical Perspective
- (2012) Rachana Patel et al. CURRENT PHARMACEUTICAL DESIGN
- Clinical significance of intratumoral HER2 heterogeneity in gastric cancer
- (2012) Hee Eun Lee et al. EUROPEAN JOURNAL OF CANCER
- Germline copy number variations and cancer predisposition
- (2012) Ana Cristina Victorino Krepischi et al. Future Oncology
- A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
- (2012) Niantao Deng et al. GUT
- Alterations of theTP53Gene in Gastric and Esophageal Carcinogenesis
- (2012) Marilanda Ferreira Bellini et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Quantitative Analysis of Diagnostic Guidelines for HER2-Status Assessment
- (2012) Albrecht Stenzinger et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification
- (2012) W. Okamoto et al. MOLECULAR CANCER THERAPEUTICS
- Losses of Chromosome 5q and 14q Are Associated with Favorable Clinical Outcome of Patients with Gastric Cancer
- (2012) T. E. Buffart et al. ONCOLOGIST
- Chromogenicin situhybridization (CISH) to detectHER2gene amplification in breast and gastric cancer: Comparison with immunohistochemistry (IHC) and fluorescencein situhybridization (FISH)
- (2012) Shinichiro Kiyose et al. PATHOLOGY INTERNATIONAL
- Whole exome sequencing of pediatric gastric adenocarcinoma reveals an atypical presentation of Li-Fraumeni syndrome
- (2012) Vivian Y. Chang et al. PEDIATRIC BLOOD & CANCER
- Integration of DNA Copy Number Alterations and Transcriptional Expression Analysis in Human Gastric Cancer
- (2012) Biao Fan et al. PLoS One
- High-Throughput Mutation Profiling Identifies Frequent Somatic Mutations in Advanced Gastric Adenocarcinoma
- (2012) Jeeyun Lee et al. PLoS One
- Epidermal growth factor receptor overexpression/amplification in adenocarcinomas arising in the gastrointestinal tract
- (2012) Elisa Rossi et al. REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
- Genetic Aspects of Gastric Cancer Instability
- (2012) Petra Hudler TheScientificWorldJOURNAL
- Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas
- (2012) Yuan-Yuan Liu WORLD JOURNAL OF GASTROENTEROLOGY
- Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant
- (2012) Jessica Maddox et al. PLoS Genetics
- Mitochondrial DNA Copy Number and Risk of Gastric Cancer: a Report from the Shanghai Women's Health Study
- (2011) L. M. Liao et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- MET Expression and Amplification in Patients with Localized Gastric Cancer
- (2011) Y. Y. Janjigian et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Hybridization for human epidermal growth factor receptor 2 testing in gastric carcinoma: a comparison of fluorescence in-situ hybridization with a novel fully automated dual-colour silver in-situ hybridization method
- (2011) Elena García-García et al. HISTOPATHOLOGY
- Comprehensive analysis of HER2 expression and gene amplification in gastric cancers using immunohistochemistry and in situ hybridization: which scoring system should we use?
- (2011) Young Soo Park et al. HUMAN PATHOLOGY
- MYC, TP53,and Chromosome 17 Copy-Number Alterations in Multiple Gastric Cancer Cell Lines and in Their Parental Primary Tumors
- (2011) Mariana Ferreira Leal et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Genetic Activation of theMETPathway and Prognosis of Patients With High-Risk, Radically Resected Gastric Cancer
- (2011) Francesco Graziano et al. JOURNAL OF CLINICAL ONCOLOGY
- METAmplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib
- (2011) Jochen K. Lennerz et al. JOURNAL OF CLINICAL ONCOLOGY
- Energy in and Energy out: What Matters for Survivors of Colorectal Cancer?
- (2011) Justin Y. Jeon et al. JOURNAL OF CLINICAL ONCOLOGY
- Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny
- (2011) Rui Bi et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Cilia, adenomatous polyposis coli and associated diseases
- (2011) Z Li et al. ONCOGENE
- Experimental Gastric Carcinogenesis in Cebus apella Nonhuman Primates
- (2011) Joana de Fátima Ferreira Borges da Costa et al. PLoS One
- Molecular targeted agents for gastric and gastroesophageal junction cancer
- (2011) Takashi Oshima et al. SURGERY TODAY
- Assessment of ERBB2 and EGFR gene amplification and protein expression in gastric carcinoma by immunohistochemistry and fluorescence in situ hybridization
- (2011) Wang YK et al. Molecular Cytogenetics
- Cytogenetic characterization and evaluation of c-MYC gene amplification in PG100, a new Brazilian gastric cancer cell line
- (2010) H.F. Ribeiro et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- MYC in gastric carcinoma and intestinal metaplasia of young adults
- (2010) Danielle Queiroz Calcagno et al. CANCER GENETICS AND CYTOGENETICS
- From Gastric Inflammation to Gastric Cancer
- (2010) Jan Bornschein et al. DIGESTIVE DISEASES
- Trastuzumab in gastric cancer
- (2010) Alicia F.C. Okines et al. EUROPEAN JOURNAL OF CANCER
- Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
- (2010) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- DrosophilaOctamer Elements and Pdm-1 Dictate the Coordinated Transcription of Core Histone Genes
- (2010) Mei-Chin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p53: The Attractive Tumor Suppressor in the Cancer Research Field
- (2010) Toshinori Ozaki et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Inactivation of the Gastrokine 1 gene in gastric adenomas and carcinomas
- (2010) Jung Hwan Yoon et al. JOURNAL OF PATHOLOGY
- Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma
- (2010) Shidou Zhao et al. JOURNAL OF PATHOLOGY
- Analysis of DNA copy number aberrations by multiple ligation-dependent probe amplification on 50 intestinal type gastric cancers
- (2010) Dai Zhang et al. JOURNAL OF SURGICAL ONCOLOGY
- Identification of novel gastric cancer-associated CNVs by integrated analysis of microarray
- (2010) Chan-Hee Park et al. JOURNAL OF SURGICAL ONCOLOGY
- Highlights 2010
- (2010) Joanna Palmer LANCET
- Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression
- (2010) Zhengyu Fang et al. MEDICAL ONCOLOGY
- The impact of C-MYC gene expression on gastric cancer cell
- (2010) Lin Zhang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?
- (2010) A. A. Dar et al. MOLECULAR CANCER THERAPEUTICS
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Targeting mitochondria for cancer therapy
- (2010) Simone Fulda et al. NATURE REVIEWS DRUG DISCOVERY
- Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma
- (2010) X Guo et al. ONCOGENE
- Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy
- (2010) H K Kim et al. PHARMACOGENOMICS JOURNAL
- Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer
- (2009) Wen-Yi Hung et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population
- (2009) Guangfu Jin et al. CARCINOGENESIS
- DNA variations in human and medical genetics: 25 years of my experience
- (2009) Yusuke Nakamura JOURNAL OF HUMAN GENETICS
- Developing c-MET pathway inhibitors for cancer therapy: progress and challenges
- (2009) Xiangdong Liu et al. TRENDS IN MOLECULAR MEDICINE
- Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions
- (2008) Altaf A. Dar et al. CANCER
- Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers
- (2008) R. J. Leary et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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