Article
Plant Sciences
In Gyoung Ju, Eugene Huh, Namkwon Kim, Seungmin Lee, Jin Gyu Choi, Jongki Hong, Myung Sook Oh
Summary: This study showed that Artemisiae Iwayomogii Herba (AIH) attenuates neuroinflammation by regulating the NF-kappa B and MAPK pathways, and it may be used for treating neurological diseases. The inhibitory effects of AIH on microglia-mediated neuroinflammation and NLRP3 inflammasome formation were demonstrated both in vitro and in a mouse model.
Article
Pharmacology & Pharmacy
S. M. Jeong, M. J. Kim, G. E. Woo, D. H. Ahn
Summary: This study found that Sargassum muticum ethanol extract has anti-inflammatory activity both in vitro and in vivo. It inhibits the production of nitric oxide, interleukin-6, and tumor necrosis factor alpha induced by lipopolysaccharide, and suppresses the expression of inducible nitric oxide synthase and cyclooxygenase-2. Furthermore, it induces anti-inflammatory effects by inhibiting the phosphorylation of several signaling pathways.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Immunology
Debjeet Sur, Chaitali Mondal, Ashok Kumar Balaraman, Pallab Kanti Haldar, Himangshu Sekhar Maji, Asis Bala
Summary: This study investigates the anti-inflammatory mechanism of monoamine oxidase inhibitor (MAOI) in carrageenan-induced inflammation models and explores the role of the MAO-mediated H2O2-NF-kappa B-COX-2 pathway in acute inflammation. The results show that MAOI exhibits anti-inflammatory and H2O2 scavenging activities, reducing swelling, leukocyte extravasation, and the levels of COX-2, PGE(2), and NF-kappa B in inflamed tissue.
INFLAMMOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Chen Tzufan, Chen Chuntzu, Huang Yuanli, Baskaran Rathinasamy, J. p tsai Jeffrey, H. U. Rouhmei
Summary: The study evaluated the immune modulatory response of Puhuang, showing that its extracts have inhibitory effects on inflammatory activity of macrophage cells and work by inhibiting the expression of inflammatory regulators. The phytochemical constituents present in Typha angustifolia Linn exhibit strong antioxidant activities and high levels of flavonoids and phenolic contents.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Won Ko, Tae-Won Kim
Summary: Green tea extract (GTE) is able to restore CP-induced immunosuppression and activate immune activity in macrophages. These findings suggest the potential of GTE as a supplementary agent in CP chemotherapy.
Article
Biotechnology & Applied Microbiology
Aimin Liu, Buxin Zhang, Wei Zhao, Yuanhui Tu, Qingxing Wang, Jing Li
Summary: This study aims to investigate the therapeutic role of catalpol in psoriasis, and the results suggest that catalpol may ameliorate psoriasis symptoms by reducing oxidative stress and inflammation, possibly through SIRT1-mediated suppression of NF-.B and MAPKs pathways.
Article
Biochemistry & Molecular Biology
Xuefeng Wang, Haiming Hu, Baifei Hu, Hui Xia, Xue Cheng, Junping Zheng, Zhigang Zhang, Hongtao Liu
Summary: This study demonstrates that Dihydromyricetin (DHM) can suppress HBV replication in HepG2.2.15 cells by activating NF-kappa B, MAPKs, and autophagy. These findings provide new insights into the clinical treatment of HBV infection using DHM.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cell Biology
Quan Chen, Hongjian Lu, Chengwei Duan, Xiangyang Zhu, Yi Zhang, Mengmeng Li, Dongmei Zhang
Summary: The study found that PDCD4 may serve as a key regulatory molecule in central nervous system neuroinflammation and oxidative stress-induced neuronal apoptosis, regulating both microglial inflammatory activation and neuronal apoptosis, forming a positive feedback loop. This discovery provides a new perspective for potential therapeutic targets in neuroinflammatory diseases.
Review
Biochemistry & Molecular Biology
Chaekyun Kim
Summary: Bone homeostasis is regulated by the balanced actions of osteoblasts and osteoclasts, which differentiate from different progenitor cells. Mitogen-activated protein kinases (MAPKs), including ERKs, play a crucial role in the differentiation and function of osteoclasts. However, the role of ERKs in osteoclast differentiation is still controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
W. U. Mingyun, Y. U. Jianer, B. A. Li, X. U. E. Zheng, Jiang Shenhua, L. Liqing, Piao Xiang, X. U. Wanchao, Wang Jiani, Shen Qian
Summary: The study demonstrated that Pingchuan formula can effectively treat allergic asthma by attenuating inflammatory response through inhibiting the NF-Kappa B/MAPK signaling pathway. This has important implications for clinical treatment and further understanding of the disease pathogenesis.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mohamad-nabi Moradi, Hamid Behrouj, Behnam Alipoor, Nejat Kheiripour, Hadi Ghasemi, Hassan Ghasemi
Summary: The study found that C. vulgaris significantly reversed the effects of NAFLD-related complications induced by a high-fat diet, especially at a 10% dose. C. vulgaris may improve NAFLD by modulating inflammatory gene expression, alleviating insulin resistance, and improving dyslipidemia. Scientists may find the results useful in developing effective supplements from C. vulgaris to address NAFLD-related complications.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Kwan-Woo Kim, Young-Seob Lee, Dahye Yoon, Geum-Soog Kim, Dae Young Lee
Summary: The 50% ethanolic extract of Curcuma longa (CLE) has been found to have anti-neuroinflammatory effects against LPS-induced microglial cells activation. CLE inhibits the production and expression of pro-inflammatory mediators by negative regulation of NF-kappa B and MAPK signaling pathways. These effects are mediated by the HO-1/Nrf2 signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Pharmacology & Pharmacy
Kangyi Zhang, Xiaochun Teng
Summary: This study aimed to investigate the protective role of mimetic peptide Ac2-26 of annexin A1 in regulating p38MAPK/NF-Kappa B in a diabetic mouse model. The results showed that treatment with Ac2-26 significantly improved fasting blood glucose, blood lipid levels, and renal function, while reducing body weight in the Ac2-26 group compared to the model group. The levels of inflammatory factors in renal tissue were also significantly decreased in the Ac2-26 group. Moreover, the mRNA and protein expressions of p38MAPK, NF-Kappa BP6, and ANXA1 were significantly reduced in the Ac2-26 group.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hong Zhang, Jiawei Mu, Jinqiu Du, Ying Feng, Wenhui Xu, Mengmeng Bai, Huijuan Zhang
Summary: Chemerin is associated with diabetic nephropathy (DN) progression via the P38 MAPK pathway, while alpha-lipoic acid (alpha-LA) may prevent the effects of Chemerin on DN progression through the same pathway.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Kangyi Zhang, Xiaochun Teng
Summary: This study examined the protective effect of the mimetic peptide AC2-26 of Annexin A1 against renal inflammatory injury in a diabetic mice model. The results showed that AC2-26 significantly decreased blood glucose and lipids levels, improved renal function, and reduced inflammatory factors. Furthermore, AC2-26 suppressed the p38MAPK/NF-kappa B pathway and alleviated renal inflammation. These findings suggest that AC2-26 may be a potential treatment for renal disease in diabetics.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)