Article
Biochemistry & Molecular Biology
Jiao Xiao, Yingjie Wang, Yanqiu Yang, Jingyu Liu, Gang Chen, Bin Lin, Yue Hou, Ning Li
Summary: Stephania epigaea, a folk medicine in southern China, has been found to contain alkaloids that can inhibit neuroinflammation. These alkaloids may have potential therapeutic effects for neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Laura Peeters, Kenn Foubert, Mamadou Aliou Balde, Emmy Tuenter, An Matheeussen, Natascha Van Pelt, Guy Caljon, Nina Hermans, Luc Pieters
Summary: The traditional medicinal plant Nauclea pobeguinii is used for treating malaria. Research on the plant extract and strictosamide, a potential active compound, suggests that alkaloids in the extract undergo biotransformation to become active compounds after oral administration. The study found a diverse range of compounds in the extract, mainly saponins and alkaloids, contributing to its antiplasmodial activity.
Article
Chemistry, Applied
Haoran Ma, Xiaoqi Jin, Fuqian Wang, Jie Jiang, Lu Cheng, Song Hu, Geng Zhang, Hongfeng Xu
Summary: A new morphinan alkaloid and a new cularine alkaloid were isolated from the roots of Stephania cepharantha, both of which showed cytotoxic activities against human cancer cell lines. The structures of these compounds were determined by spectroscopic data analyses.
NATURAL PRODUCT RESEARCH
(2023)
Article
Parasitology
Jesus Garcia Diaz, Emmy Tuenter, Julio Cesar Escalona Arranz, Gabriel Llaurado Maury, Paul Cos, Luc Pieters
Summary: This study evaluated the antiplasmodial effect of alkaloids from Croton linearis and found that laudanidine and 8,14-dihydrosalutaridine exhibited moderate antiplasmodial activity without cytotoxicity. This finding is significant for the development of new antimalarial drugs.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Multidisciplinary Sciences
Beibei Qi, Liangbo Li, Rongshao Huang
Summary: The genus Stephania is a rich source of alkaloids and has been traditionally used in China for treating various ailments. However, there is limited understanding of the variation within the genus, which hinders its optimal utilization. This study evaluated the variation in alkaloid content in four commonly cultivated Stephania species in China. The results revealed significant variations in alkaloid abundance among the species, with the genotypes SY-xueteng and SY-hongteng showing relatively high alkaloid abundance. This study provides a foundation for the further utilization of ideal Stephania genotypes by clarifying alkaloid content variations within the genus.
Article
Biochemistry & Molecular Biology
Jiao Xiao, Yingjie Wang, Yanqiu Yang, Jingyu Liu, Bin Lin, Gang Chen, Ning Li
Summary: 16 alkaloids, including 11 new hasubanan alkaloids and five known alkaloids, were isolated from the alkaloidal extract of Stephania longa through 1H NMR-guided fractionation. The structures were determined by spectroscopic analysis, and the absolute configurations were established by comparing experimental and calculated ECD spectra. Compound 3 and compound 12 showed stronger antineuroinflammatory effects than minocycline against NO production on LPS-activated BV2 cells.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Li-Jun Yang, Zhong-Duo Yang, Zhi-Jie Li, Shu-Hong Yang, Zong-Mei Shu
Summary: Four undescribed bisbenzylisoquinoline alkaloids were isolated and identified from the roots of Stephania tetrandra, along with the isolation of N-trans-Feruloyltyramine for the first time from this plant. Stephtetrandrine C exhibited significant inhibitory effect on human hepatoma cell HepG2, while Limacine and 2'-N-chloromethyltetrandrine showed moderate monoamine oxidase inhibitory effects.
NATURAL PRODUCT RESEARCH
(2023)
Article
Cell Biology
Xinyi Li, Qishuang Li, Xiang Jiao, Hao Tang, Yatian Cheng, Ying Ma, Guanghong Cui, Jinfu Tang, Yun Chen, Juan Guo, Luqi Huang
Summary: In this study, two functional StNCSs genes were identified and characterized from the Menispermaceae family plant Stephania tetrandra. These genes could catalyze the formation of (S)-norcoclaurine and provide genetic components for synthetic biology-based production of BIAs in yeast. The study also contributes to understanding the phylogenetic relationships and structure-function relationship of NCS genes involved in the origin and production of BIAs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Microbiology
Fidelia Ijeoma Uche, Xiaozhen Guo, Jude Okokon, Imran Ullah, Paul Horrocks, Joshua Boateng, Chenggang Huang, Wen-Wu Li
Summary: This study investigates the in vitro and in vivo antiplasmodial activities of BBIQ alkaloids and their analogues, showing promising results with significant anti-parasitic effects at low concentrations. Cycleanine and its semisynthetic analogues demonstrate improved potency and selectivity, with potential as leads for further drug development.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Chang-Kwon Kim, Jayeon Yu, DucDat Le, Sanghee Han, Soojung Yu, Mina Lee
Summary: In this study, three new caffeic acid benzyl ester (CABE) analogs and eight known compounds were isolated from Ilex rotunda. Compound 2 demonstrated significant anti-inflammatory properties by suppressing the production of pro-inflammatory mediators and cytokines. Molecular docking simulations showed potential interactions between compound 2 and iNOS protein, suggesting its potential as a candidate for treating inflammatory bowel disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sylvian Cretton, Gregory Genta-Jouve, Marcel Kaiser, Pascal Maeser, Orlando Munoz, Thomas Buergi, Muriel Cuendet, Philippe Christen
Summary: Chemical investigation of Schizanthus tricolor led to the isolation and characterization of 26 hygroline derivatives, 20 of which were fully characterized. These newly identified compounds exhibited low cytotoxicity and showed promising activity against Plasmodium falciparum.
Article
Chemistry, Medicinal
Larissa Kom Ma'mag, Auguste Abouem A. Zintchem, Kopa Kowa Theodora, Alex de Theodore Atchade, Tchokouaha Yamthe Lauve, Michel Frederich, Dominique Serge Ngono Bikobo, Dieudonne Emmanuel Pegnyemb
Summary: The phytochemical study of Funtumia elastica leaves led to the isolation of three undescribed ursane derivatives and a new compound, with their structures elucidated and bioactivities evaluated. Some compounds showed good antimalarial effects, with the crude extract demonstrating strong anti-parasitic activities.
Article
Biochemistry & Molecular Biology
Duc Hoang Lande, Abed Nasereddin, Arne Alder, Tim W. Gilberger, Ron Dzikowski, Johann Gruenefeld, Conrad Kunick
Summary: Malaria is a dangerous infectious disease for which novel antiplasmodial agents are needed due to parasite resistance. N-unsubstituted bisindolylcyclobutenediones were designed as potential drugs and showed promising antiplasmodial activity through molecular docking and synthesis.
Review
Integrative & Complementary Medicine
Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck Chan
Summary: Tetrandrine (TET) and fangchinoline (FAN) are dominant bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra, showing anticancer properties on colon and breast cancer cells. They inhibit cell proliferation and migration through various molecular mechanisms and signaling pathways, with potential to reverse multidrug resistance in cancer cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Plant Sciences
Anmol, Surekha Kumari, Rakesh Kumar, Raman Singh, Gaurav Aggarwal, Prakhar Agrawal, Dinkar Sahal, Upendra Sharma
Summary: This study provides evidence for the traditionally medicinal use of Aconitum heterophyllum in treating malaria. The chloroform fraction of the roots was found to have the highest anti-plasmodial activity, attributed to the presence of the compound 2-O-cinnamoyl hetisine. Additionally, a new UHPLC-DAD analytical method was developed for quantification of marker compounds and quality assessment of this medicinal plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
D. Yu. Yusifova, I. S. Movsumov, E. A. Garaev, V. Mahiou-Leddet, F. Mabrouki, G. Herbette, B. Baghdikian, E. Ollivier
CHEMISTRY OF NATURAL COMPOUNDS
(2015)
Article
Chemistry, Medicinal
I. S. Movsumov, D. Yu. Yusifova, T. A. Suleimanov, V. Mahiou-Leddet, G. Herbette, B. Baghdikian, E. E. Garayev, E. Ollivier, E. A. Garayev
CHEMISTRY OF NATURAL COMPOUNDS
(2016)
Article
Chemistry, Multidisciplinary
Beatrice Baghdikian, Aurore Filly, Anne-Sylvie Fabiano-Tixier, Emmanuel Petitcolas, Fathi Mabrouki, Farid Chemat, Evelyne Ollivier
COMPTES RENDUS CHIMIE
(2016)
Article
Food Science & Technology
Emmanuelle Travaille, Stephanie La Carbona, Gilles Gargala, Dominique Aubert, Karine Guyot, Aurelien Dumetre, Isabelle Villena, Maryline Houssin
Article
Biotechnology & Applied Microbiology
Jeanne Hohweyer, Catherine Cazeaux, Emmanuelle Travaille, Emilie Languet, Aurelien Dumetre, Dominique Aubert, Christine Terryn, Jitender P. Dubey, Nadine Azas, Maryline Houssin, Favennec Loic, Isabelle Villena, Stephanie La Carbona
Article
Chemistry, Applied
Chhavarath Dary, Sok-Siya Bun, Gaeetan Herbette, Fathi Mabrouki, Hot Bun, Sothea Kim, Florian Jabbour, Sovanmoly Hul, Beatrice Baghdikian, Evelyne Ollivier
NATURAL PRODUCT RESEARCH
(2017)
Article
Chemistry, Medicinal
Elnur Garayev, Gaetan Herbette, Carole Di Giorgio, Philippe Chiffolleau, David Roux, Huguette Sallanon, Evelyne Ollivier, Riad Elias, Beatrice Baghdikian
Article
Multidisciplinary Sciences
Wesley Freppel, Pierre-Henri Puech, David J. P. Ferguson, Nadine Azas, Jitender P. Dubey, Aurelien Dumetre
SCIENTIFIC REPORTS
(2016)
Article
Biotechnology & Applied Microbiology
Angelique Rousseau, Sandie Escotte-Binet, Stephanie La Carbona, Aurelien Dumetre, Sophie Chagneau, Loic Favennec, Sophie Kubina, Jitender P. Dubey, Didier Majou, Aurelie Bigot-Clivot, Isabelle Villena, Dominique Aubert
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Immunology
Omar Ndao, Pierre-Henri Puech, Camille Berard, Laurent Limozin, Sameh Rabhi, Nadine Azas, Jitender P. Dubey, Aurelien Dumetre
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Parasitology
Aurelien Dumetre, Jitender P. Dubey, David J. P. Ferguson
Summary: Toxoplasma gondii oocysts are resistant to common chemical disinfectants, such as household bleach, due to the structure and molecular nature of the oocyst and sporocyst walls. This study revealed that bleach can remove the outer layers of the oocyst and sporocyst walls, potentially through degradation of specific proteins and glycoproteins. The inner layers of the oocyst and sporocyst walls are identified as the key structures responsible for the parasite's resistance to bleach.
Article
Parasitology
Karen Shapiro, Lillian Bahia-Oliveira, Brent Dixon, Aurelien Dumetre, Luz A. de Wit, Elizabeth VanWormer, Isabelle Villena
FOOD AND WATERBORNE PARASITOLOGY
(2019)
Review
Parasitology
Angelique Rousseau, Stephanie La Carbona, Aurelien Dumetre, Lucy J. Robertson, Gilles Gargala, Sandie Escotte-Binet, Loic Favennec, Isabelle Villena, Cedric Gerard, Dominique Aubert
Article
Chemistry, Medicinal
I. S. Movsumov, E. E. Garaev, G. Herbette, B. Baghdikian, E. Ollivier, R. Elias, T. A. Suleimanov, E. A. Garaev
CHEMISTRY OF NATURAL COMPOUNDS
(2017)
Article
Chemistry, Multidisciplinary
Diana Simona Antal, Florina Ardelean, Iulia Pinzaru, Florin Borcan, Ionut Ledeti, Dorina Coricovac, Istvan Zupko, Beatrice Baghdikian, Evelyne Ollivier, Codruta Soica, Sorin Lucian Bolinitineanu
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)