An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline (alkaloids) from Stephania tetrandra roots

Bioactive bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra

(2020) Renzhong Wang et al.   BIOORGANIC CHEMISTRY

Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo

(2020) Chun-hui Wang et al.   Evidence-based Complementary and Alternative Medicine

Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells

(2020) Yachun Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

(2020) Fei Luan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

History of uses, phytochemistry, pharmacological activities, quality control and toxicity of the root of Stephania tetrandra S. Moore: A review

(2020) Yuelin Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase

(2019) JiaNan Li et al.   BIOSCIENCE REPORTS

Tetrandrine induces apoptosis in human neuroblastoma through regulating the Hippo/YAP signaling pathway

(2019) Qian Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?

(2019) Rui-Mei Feng et al.   Cancer Communications

Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells

(2019) Wencheng Xu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibition of laryngeal cancer stem cells by tetrandrine

(2019) Xiangyan Cui et al.   ANTI-CANCER DRUGS

Design, synthesis and in vitro evaluation of fangchinoline derivatives as potential anticancer agents

(2019) Yan-chun Zhang et al.   BIOORGANIC CHEMISTRY

Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway

(2019) Jin Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression

(2019) Dan Liao et al.   MOLECULES

Tetrandrine and cancer – An overview on the molecular approach

(2018) Bhagya N. et al.   BIOMEDICINE & PHARMACOTHERAPY

Anticancer activity of tetrandrine by inducing pro-death apoptosis and autophagy in human gastric cancer cells

(2018) Xin-Yu Bai et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular Targets Modulated by Fangchinoline in Tumor Cells and Preclinical Models

(2018) Myriam Mérarchi et al.   MOLECULES

TGF-β1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells

(2017) Qian-Zhao Chen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Design, Synthesis and Anticancer Evaluation of Fangchinoline Derivatives

(2017) Yazhou Liu et al.   MOLECULES

Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK

(2017) Jie Shi et al.   ONCOLOGY REPORTS

Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells

(2017) Hyo-Seon Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms

(2017) Vincent Kam Wai Wong et al.   Frontiers in Pharmacology

Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and their Structure-activity Relationship

(2017) Zhi-Xing Qing et al.   CURRENT MEDICINAL CHEMISTRY

Tetrandrine reverses epithelial-mesenchymal transition in bladder cancer by downregulating Gli-1

(2016) YONGJIAN ZHANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Tetrandrine – A molecule of wide bioactivity

(2016) N. Bhagya et al.   PHYTOCHEMISTRY

Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms

(2016) Yuan-Li Huang et al.   PHYTOMEDICINE

A novel derivative of tetrandrine (H1) induces endoplasmic reticulum stress-mediated apoptosis and prosurvival autophagy in human non-small cell lung cancer cells

(2016) Yidan Lin et al.   TUMOR BIOLOGY

Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy

(2016) Ting Liu et al.   Oncotarget

Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents

(2015) Yu-Chin Lin et al.   BMC Complementary and Alternative Medicine

Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells

(2015) FENG TIAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Simultaneous Determination of Fangchinoline and Tetrandrine in Qi-Fang-Xi-Bi-Granules by RP-HPLC

(2015) XinGang Lu et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Fangchinoline suppresses the growth and invasion of human glioblastoma cells by inhibiting the kinase activity of Akt and Akt-mediated signaling cascades

(2015) Bingyu Guo et al.   TUMOR BIOLOGY

Fangchinoline inhibits the proliferation of SPC-A-1 lung cancer cells by blocking cell cycle progression

(2015) XUE LUO et al.   Experimental and Therapeutic Medicine

Fangchinoline Inhibits Cell Proliferation Via Akt/GSK-3beta/cyclin D1 Signaling and Induces Apoptosis in MDA-MB-231 Breast Cancer Cells

(2014) Chang-Dong Wang et al.   Asian Pacific Journal of Cancer Prevention

Multi-drug resistance in cancer chemotherapeutics: Mechanisms and lab approaches

(2014) Qiong Wu et al.   CANCER LETTERS

Breast Cancer: Epidemiology and Etiology

(2014) ZiQi Tao et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Syntheses and anti-cancer activities of derivatives of tetrandrine and fangchinoline

(2014) Yazhou Liu et al.   CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities

(2014) T.P. Tim Cushnie et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells

(2014) KE WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549

(2014) Bingyu Guo et al.   JOURNAL OF DRUG TARGETING

Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells

(2014) Yan Fang Sun et al.   PHYTOMEDICINE

Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy

(2013) AN-CHENG HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Tetrandrine inhibits hepatocellular carcinoma cell growth through the caspase pathway and G2/M phase

(2013) VIVIAN W.L. YU et al.   ONCOLOGY REPORTS

Fangchinoline Induces G1 Arrest in Breast Cancer Cells Through Cell-Cycle Regulation

(2013) Zhibo Xing et al.   PHYTOTHERAPY RESEARCH

Tetrandrine Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer BGC-823 Cells

(2013) Rong Qin et al.   PLoS One

Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells

(2013) YUPING WANG et al.   Experimental and Therapeutic Medicine

The Potential of Tetrandrine Against Gliomas

(2012) Yun Chen et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagy-related Gene 7 (ATG7) and Reactive Oxygen Species/Extracellular Signal-regulated Kinase Regulate Tetrandrine-induced Autophagy in Human Hepatocellular Carcinoma

(2012) Ke Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

(2011) Ning Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo

(2011) Yuxing Zhang et al.   CANCER LETTERS

Fangchinoline Inhibits Breast Adenocarcinoma Proliferation by Inducing Apoptosis

(2011) Zhi-Bo Xing et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Simultaneous determination of tetrandrine and fangchinoline in herbal medicine Stephania tetrandra S. Moore by liquid chromatography with electrochemical detection

(2011) Lihong Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Tetrandrine, a Compound Common in Chinese Traditional Medicine, Preferentially Kills Breast Cancer Tumor Initiating Cells (TICs) In Vitro

(2011) Wei Xu et al.   Cancers

Fangchinoline Induced G1/S Arrest by Modulating Expression of p27, PCNA, and Cyclin D in Human Prostate Carcinoma Cancer PC3 Cells and Tumor Xenograft

(2010) Chang-Dong WANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Involvement of PI3K/AKT/GSK3ß pathway in tetrandrine-induced G1 arrest and apoptosis

(2010) Xuan Li Chen et al.   CANCER BIOLOGY & THERAPY

Two New Curine-Type Bisbenzylisoquinoline Alkaloids from the Roots of Cyclea wattii with Cytotoxic Activities

(2010) Jian-Zhong Wang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma

(2010) Chaoyang Liu et al.   INTERNATIONAL JOURNAL OF CANCER

The genus Stephania (Menispermaceae): Chemical and pharmacological perspectives

(2010) Deepak Kumar Semwal et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tetrandrine Inhibits Wnt/ -Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer

(2010) B.-C. He et al.   MOLECULAR PHARMACOLOGY

Worldwide Variations in Colorectal Cancer

(2009) M. M. Center et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice

(2009) Jiann-Ming Wu et al.   CANCER LETTERS

Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells

(2009) Hyun Sun Cho et al.   Journal of Veterinary Science