Article
Food Science & Technology
Liting Qing, Shu Li, Shiying Yan, Chengmeng Wu, Xin Yan, Zongyu He, Qian Chen, Min Huang, Caihong Shen, Songtao Wang, Mei Cao, Jian Zhao
Summary: In this study, the quantification of main monomers in tartary buckwheat bran flavonoids extract was done through HPLC analysis. The anti-H. pylori activity and cell inflammation effect of the extract and its four main flavonoid monomers were investigated. The results showed that tartary buckwheat flavonoids extract and its monomers inhibited H. pylori growth and down-regulated the expression of proinflammatory factors in H. pylori-induced cells. Moreover, the extract was also found to reduce the expression of virulence factor gene of H. pylori. Overall, tartary buckwheat can alleviate H. pylori-induced cell inflammation, providing a theoretical basis for its development as healthcare products.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Eman Al-Sayed, Haidy A. Gad, Dina M. El-Kersh
Summary: This study identified the composition of four Piper essential oils using gas chromatography mass spectrometry and other techniques, revealing their inhibitory effects on Helicobacter pylori. Among the oils, Piper longum oil exhibited the most efficient anti-Helicobacter activity.
Article
Food Science & Technology
Jingfei Hu, Xueqing Tian, Tong Wei, Hangjie Wu, Jing Lu, Mingsheng Lyu, Shujun Wang
Summary: The exopolysaccharide (EPS) extracted from Lactobacillus plajomi PW-7 showed antibacterial activity and antioxidant capacity against Helicobacter pylori. It has a potential application in developing EPS-based foods. The structural characteristics and biological activity of EPS play a key role in its potential applications.
Article
Microbiology
Tran Thi Dieu Thuy, Pei-Yun Kuo, Sha-Ma Lin, Cheng-Yen Kao
Summary: This study evaluated and compared the anti-Helicobacter pylori activity of three potential probiotic strains and found that SLC13 showed the highest adhesion ability and inhibitory activity. It also alleviated the inflammatory response induced by H. pylori infection.
Article
Biochemistry & Molecular Biology
Mauricio Osorio, Marcela Carvajal, Alejandra Vergara, Estefania Butassi, Susana Zacchino, Carolina Mascayano, Margarita Montoya, Sophia Mejias, Marcelo Cortez-San Martin, Yesseny Vasquez-Martinez
Summary: Prenylated flavonoids are important natural compounds with significant biological activity, particularly in antimicrobial functions. Compounds 11, 12, and 13 showed strong inhibitory activity against human pathogenic fungi and clinical isolated Staphylococcus aureus MRSA, indicating the key structural requirements for antibacterial activity. Additionally, the combination of prenylated flavonoids with commercial antibiotics significantly enhanced the antibacterial activity against drug-resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Ying Liu, Pinyi Gao, Xiao Liang, Yangyang Zhang, Xiaoqi Yu, Xiaobian Xue, Lara Kockaya, Pankaj Pandey, Robert J. Doerksen, Xiaojuan Wang, Guodong Yao, Wanchun Chu, Xin Chen, Shaojiang Song, Mark T. Hamann, Lingzhi Li
Summary: We discovered 23 new prenyl-flavonoids and 13 known molecules from Daphne giraldii Nitsche, some of which have significant bioactivity against hepatoma carcinoma. By combining mass spectrometry, nuclear magnetic resonance, and computational approaches, we identified a polyprenyl-flavonoid called Daphnegiratriprenylone A with a triprenyl substitution. This new approach of using computational tools for the assignment of natural product structures was found to be reliable compared to conventional techniques. Several compounds showed potent and selective activity against Hep3B cells, and polyprenyl-flavonoids were found to inhibit FGFR1, a potential target for these compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Mariana Nascimento de Paula, Taisa Dalla Valle Rorig Ribeiro, Raquel Isolani, Daniela Cristina de Medeiros Araujo, Augusto Santos Borges, Gisele Strieder Philippsen, Rita de Cassia Ribeiro Goncalves, Rodrigo Rezende Kitagawa, Flavio Augusto Vicente Seixas, Joao Carlos Palazzo de Mello
Summary: Monteverdia ilicifolia is a Brazilian native plant traditionally used to treat gastric diseases. The plant extract showed inhibitory activity against Helicobacter pylori and possessed antioxidant capacity. The presence of polyphenol compounds in the extract may play an important role in the antioxidant and inhibitory capacities against H. pylori.
Article
Chemistry, Medicinal
Mariana Nascimento de Paula, Maren Kelm, Nico Symma, Raquel Garcia Isolani, Fernanda Pilatti da Silva, Jandirk Sendker, Andreas Hensel, Joao Carlos Palazzo de Mello
Summary: Maytenus ilicifolia, a Brazilian medicinal plant, shows anti-adhesive effects against Helicobacter pylori by interacting with the bacteria's adhesion systems. The extracts do not affect bacterial proliferation or mitochondrial activity of human stomach cells. LC-MS studies reveal the presence of flavonoid glycosides and oligomeric proanthocyanidins in the active components.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)
Article
Biochemistry & Molecular Biology
Jaroslaw Widelski, Piotr Okinczyc, Katarzyna Susniak, Anna Malm, Anna Bozhadze, Malkhaz Jokhadze, Izabela Korona-Glowniak
Summary: Georgian propolis has anti-H. pylori activity and can be used as an adjuvant in the therapy of H. pylori infection.
Article
Chemistry, Multidisciplinary
Dong-Min Kang, Atif Ali Khan Khalil, Woo Sung Park, Hye-Jin Kim, Kazi-Marjahan Akter, Ji-Yeong Bae, Sultan Mehtap Buyuker, Jung-Hwan Kim, Kwon Kyoo Kang, Mi-Jeong Ahn
Summary: This study isolated six compounds from Rumex acetosa that showed anti-H. pylori activity, making them potential natural candidates for the treatment of H. pylori infection. Two of the compounds exhibited high antibacterial activity against H. pylori strains.
Article
Chemistry, Organic
Ming-Ming Xu, Junfei Zhou, Liping Zeng, Jingchen Xu, Monday M. Onakpa, Jin-Ao Duan, Chun-Tao Che, Hongkai Bi, Ming Zhao
Summary: An unprecedented dimeric pimarane-derived diterpenoid and a new 17-nor-(9 beta-H)-pimarane diterpenoid glucoside, along with ten known analogs, were isolated from the tuber of Icacina trichantha in a bioassay-guided phytochemical investigation. These compounds exhibited antibacterial activity against standard and drug-resistant Helicobacter pylori strains, with icacinlactone B showing an additive effect in combination with metronidazole or clarithromycin.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Biochemistry & Molecular Biology
Shaochun Shi, Jichong Li, Xuemei Zhao, Qingbo Liu, Shao-Jiang Song
Summary: Prenylated flavonoids, with a combination of flavonoid skeleton and lipophilic prenyl side-chain, have shown great potential in various biological activities, making them valuable in medicinal chemistry research and treatment of multi-factorial diseases in clinic.
Article
Chemistry, Multidisciplinary
Se Yun Jeong, Myung Woo Na, Eon Chung Park, Jin-Chul Kim, Dong-Min Kang, Hamed Hamishehkar, Mi-Jeong Ahn, Jung Kyu Kim, Ki Hyun Kim
Summary: In this study, a phytochemical analysis of Pinus eldarica needles collected in Iran was conducted, resulting in the isolation and identification of three labdane-type diterpenes, including a new norlabdane-type diterpene. These diterpenes exhibited antibacterial activity against Helicobacter pylori, highlighting their potential as novel antibiotics for the treatment of gastric and duodenal ulcers.
Article
Biochemistry & Molecular Biology
Hyun Jun Woo, Ji Yeong Yang, Pyeongjae Lee, Jong-Bae Kim, Sa-Hyun Kim
Summary: The natural compound zerumbone extracted from Zingiber zerumbet Smith was found to inhibit the urease activity of H. pylori by forming dimers, trimers, or tetramers, suggesting its potential as a therapeutic agent for treating H. pylori infections in humans.
Article
Plant Sciences
Chang Peng, Shuyi Sang, Xue Shen, Weijia Zhang, Jiahui Yan, Pengting Chen, Cheng Jiang, Yuemei Yuan, Weixing Zhu, Meicun Yao
Summary: This study aimed to investigate the antibacterial activities of S. aromaticum extracts on H. pylori strains, both sensitive and resistant to antibiotics. The extracts demonstrated significant antibacterial effects, altering bacterial structure, decreasing virulence gene expression, and interfering with metabolic pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Mayra Montalvan, Manuel Alejandro Penafiel, Jorge Ramirez, Nixon Cumbicus, Nicole Bec, Christian Larroque, Carlo Bicchi, Gianluca Gilardoni
Article
Plant Sciences
Sandra Espinosa, Nicole Bec, Christian Larroque, Jorge Ramirez, Barbara Sgorbini, Carlo Bicchi, Gianluca Gilardoni
Article
Biochemistry & Molecular Biology
Dlzar A. Kheder, Omar A. M. Al-Habib, Gianluca Gilardoni, Giovanni Vidari
Article
Plant Sciences
Jessica Garcia, Gianluca Gilardoni, Nixon Cumbicus, Vladimir Morocho
Article
Plant Sciences
Mayara Vioto Valois, Cleide de Oliveira, Antonio Jose Lapa, Caden Souccar, Maria Luiza Vilela Oliva
Summary: The study demonstrated that protease inhibitors isolated from Bauhinia species have a protective effect against gastric mucosal lesions in mice and rats, mainly through inhibiting elastase activity to reduce mucosal damage.
Article
Plant Sciences
Gianluca Gilardoni, Yadira Matute, Jorge Ramirez
Article
Plant Sciences
Hawraz Ibrahim M. Amin, Faiq H. S. Hussain, Gianluca Gilardoni, Zaw Min Thu, Marco Clericuzio, Giovanni Vidari
Article
Plant Sciences
Melissa Salinas, Nicole Bec, James Calva, Christian Larroque, Giovanni Vidari, Chabaco Armijos
Summary: This study determined the physical properties, chemical composition, enantiomer distribution, and cholinesterase inhibitory activity of an essential oil from H. laricifolium. The oil exhibited selective inhibitory effects against butyrylcholinesterase, making it a potential candidate for investigating the progression of Alzheimer's disease.
Article
Chemistry, Applied
Hnin Thanda Aung, Khin Thidar Saw, Mi Mi Latt, Giovanni Vidari, Yumiko Komori, Yoshiaki Takaya
Summary: The first phytochemical investigation of specialized metabolites from the stem bark of Alyxia fascicularis was conducted. Five lignans and three coumarins were isolated and identified. The lignans showed significant radical scavenging activity. The compounds had no cytotoxic effect on Hela cell line. A possible biosynthetic pathway was suggested.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Omar Malagon, Cinthia Bravo, Giovanni Vidari, Nixon Cumbicus, Gianluca Gilardoni
Summary: Kaunia longipetiolata is a plant native to southern Ecuador, and its essential oil contains various sesquiterpenes, with alpha-zingiberene and ar-curcumene being major components. Chiral analysis identified several chiral components, and two unidentified constituents were also discovered.
Article
Biochemistry & Molecular Biology
Gianluca Gilardoni, Francesca Negri, Paola Vita Finzi, Faiq H. S. Hussain, Giovanni Vidari
Summary: The secondary metabolites of Tricholoma ustaloides were investigated through extensive chromatographic study. Several novel compounds, including tricholidic acids B and C, were isolated and characterized. Two known compounds showed high cytotoxicity against human cancer cell lines.
Article
Biochemistry & Molecular Biology
Natali Solano-Cueva, Jorge G. Figueroa, Corina Loja, Chabaco Armijos, Giovanni Vidari, Jorge Ramirez
Summary: In this study, a simple, accurate, and reliable method for analyzing the diphenolic diterpene carnosol in plants was developed and validated. The compound exhibited various biological activities, and its content in L. mutica was estimated to be 0.81 +/- 0.04 mg/g of dried leaves.
Article
Plant Sciences
Hawraz Ibrahim M. Amin, Kamaran Abdoulrahman, Azad S. Sadraddin, Heman A. Smail, Zanko Hassan Jawhar, Kovan Dilawer Issa, Chabaco Armijos, Giovanni Vidari
Summary: The volatile oils from O. carduchorum were characterized for the first time, with 43 constituents identified and quantified. Beta-elemene was found to be an abundant antiproliferative component in both oils. The oils exhibited significant antiproliferative effects against human cancer cells.
Article
Plant Sciences
James Calva, Carlos Ludena, Nicole Bec, Christian Larroque, Melissa Salinas, Giovanni Vidari, Chabaco Armijos
Summary: The chemical composition and inhibitory activities of the essential oil from Hypericum aciculare were determined. The oil showed significant inhibition of BuChE and moderate activity towards AChE.
Article
Plant Sciences
Gianluca Gilardoni, Jorge Ramirez, Mayra Montalvan, Willan Quinche, Jackeline Leon, Lita Benitez, Vladimir Morocho, Nixon Cumbicus, Carlo Bicchi
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)