Article
Biochemistry & Molecular Biology
Yong Gao, Yanan Zhang, Chen Feng, Honglong Chu, Chao Feng, Haibo Wang, Lifang Wu, Si Yin, Chao Liu, Huanhuan Chen, Zhumei Li, Zhengrong Zou, Lizhou Tang
Summary: In this study, a chromosome-level genome assembly of Amorphophallus konjac was generated, revealing the mechanisms underlying the large genome size and the key genes involved in glucomannan biosynthesis. The expansion of transposable elements was found to contribute to the large genome size, and valuable candidate genes for molecular breeding of this crop were identified.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Waleed A. S. Aldamarany, Guangming Song, Jie Liu, Sha Liu, Yuanyuan Chen, Wenjing Jiang, Geng Zhong
Summary: In this study, the effects of konjac glucomannan (KGM) and its derivatives on the pharmacokinetics and tissue distribution of antibiotics were investigated in mice. The results showed that KGM and its derivatives had specific effects on the absorption, distribution, and elimination of certain antibiotics. The ingestion of KGM and its derivatives enhanced the absorption of metronidazole and hindered the absorption of amoxicillin, while having no effect on the absorption of neomycin sulfate and vancomycin. KGM and its derivatives also affected the distribution and elimination of the antibiotics to varying degrees.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Jiajia Dai, Jian Chen, Jun Qi, Mengru Ding, Wei Liu, Taili Shao, Jun Han, Guodong Wang
Summary: The study demonstrated that Konjac glucomannan can significantly improve the immunodeficiency induced by cyclophosphamide in mice, enhancing immunity through modulation of innate and adaptive immunity.
FOOD SCIENCE & NUTRITION
(2021)
Article
Food Science & Technology
Fernanda Laignier, Rita de Cassia de Almeida Akutsu, Bernardo Romao de Lima, Renata Puppin Zandonadi, Antonio Raposo, Ariana Saraiva, Raquel Braz Assuncao Botelho
Summary: This study evaluated the sensory profile of gluten-free bread with different concentrations of Amorphophallus konjac (AK) flour. The results showed that the addition of 12.5% AK flour resulted in gluten-free bread with sensory characteristics closer to regular bread.
Article
Biochemistry & Molecular Biology
Yujie Su, Mianzhang Zhang, Cuihua Chang, Junhua Li, Yuanyuan Sun, Yundan Cai, Wen Xiong, Luping Gu, Yanjung Yang
Summary: The Amorphophallus bulbifer (A. bulbifer) has the potential to be used as KGM resources in the food industry due to its good growth characteristics and high KGM content. However, the high viscosity of KGM from A. bulbifer and the browning of KGM gels limit its application. Citric-acid treatment (CAT) significantly reduces the viscosity and ΔE value of KGM, making it valuable for developing low-calorie foods without affecting gel texture properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Meng Wang, Yun-Cheng Li, Fan-Bing Meng, Qiao Wang, Zheng-Wu Wang, Da-Yu Liu
Summary: In this study, honeysuckle leaf extract was added to the CMKH composite film. The addition of honeysuckle leaf extract slightly decreased the water vapor barrier properties of the film, but completely blocked UV transmission. The film with honeysuckle leaf extract showed higher elongation at break and exhibited strong antioxidant and antimicrobial activities.
Article
Immunology
Nioosha Ahmadi, Hamid Reza Jahantigh, Hassan Noorbazargan, Mohammad Hossein Yazdi, Mehdi Mahdavi
Summary: The study found that glucomannan, as a dietary supplement or adjuvant, can enhance immune responses in tumor-bearing mice and reduce immune response suppression in the tumor milieu. This makes glucomannan a potentially excellent therapeutic agent for lowering breast tumor growth.
Article
Food Science & Technology
Shishuai Wang, Lidong Ding, Shuo Chen, Ying Zhang, Jiaxin He, Bin Li
Summary: This study investigated the effect of konjac glucomannan (KGM) on the retrogradation of amylose. The results showed that with increasing amount of KGM, the color of the system became darker, and the elastic modulus, viscous modulus, and tangent value of loss angle increased. The textural result showed that KGM significantly inhibited the growth rate of gel strength of amylose. WHC and XRD results indicated that as the concentration of KGM increased, WHC increased and crystallinity degree declined. LF-NMR results revealed that KGM limited the conversion of free water to bound water. Overall, this research suggests that a small amount of KGM can inhibit the short-term and long-term retrogradation of amylose.
Article
Plant Sciences
Hao Cui, Xinying Zhu, Zhaoguang Wang, Jianping Fang, Tao Yuan
Summary: The structurally defined konjac glucomannan oligosaccharide (KGMOS) with specific molecular sizes showed beneficial effects on colonic functions in mice by regulating intestinal microflora composition to facilitate butyrate production, enhancing histone acetylation, and promoting mucin secretion, thus improving gut health through a new molecular mechanism.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Yan Chen, Xuefeng Gao, Bin Li, Jing Tian
Summary: The study investigated the effects of the interaction between konjac glucomannan (KGM) and dihydromyricetin (DMY) on KGM's viscosity, hydration capacity, and DMY's thermal stability. Contrary to most reports, adding DMY to KGM increased viscosity and hydration capacity and improved DMY's retention and radical scavenging capacity under heating conditions. The KGM-DMY complex was characterized as a non-covalent compound connected by hydrogen bonds. This study is beneficial for the development of polyphenol-enriched nutrition based on KGM, particularly in terms of satiety, appetite regulation, and glucose regulation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Fernanda Laignier, Rita de Cassia Coelho de Almeida Akutsu, Iriani Rodrigues Maldonade, Maria Teresa Bertoldo Pacheco, Vera Sonia Nunes Silva, Marcio Antonio Mendonca, Renata Puppin Zandonadi, Antonio Raposo, Raquel Braz Assuncao Botelho
Summary: The study found that adding different concentrations of konjac flour can improve the specific volume of gluten-free bread, reduce its calorie content, and increase fiber content. The best formulation was found with a konjac flour concentration of up to 37.5%, while the bread with 50% konjac flour showed slightly reduced specific volume and a pale color.
Article
Agriculture, Multidisciplinary
Ziqiang Duan, Yuntao Wang, Xiao Yu, Nan Wu, Jie Pang, Yanhong Bai
Summary: In this study, the effects of konjac oligo-glucomannan (KOG) on the emulsifying properties of myofibrillar protein (MP) were investigated. It was found that the addition of KOG altered the tertiary conformation of MP, resulting in improved emulsifying activity, decreased particle size, and improved physical stability of the emulsion. The findings suggest that KOG interacts with MP at the oil-water interface, forming a stable interface film to enhance the emulsifying properties of MP.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Applied
Yu Hou, He Liu, Danshi Zhu, Jun Liu, Chunli Zhang, Chunyang Li, Jinlian Han
Summary: The addition of soybean dietary fiber (SDF) improved the color, hardness, chewiness, water-and oil-holding capacities, melting temperature, thermal stability, storage modulus, and apparent viscosity of konjac glucomannan/kappa-carrageenan composite gel. SDF formed a spatial framework with KGM and kappa-CA, disrupting the cohesive structure and leading to an uneven gel structure. The results have guiding significance for the development of solid fat products simulated by SDF/KGM/kappa-CA composite gel.
FOOD HYDROCOLLOIDS
(2022)
Article
Biochemistry & Molecular Biology
Ana Carolina Santos Fernandes, Luana Muxfeldt, Neli Gehlen Motta, Calinca Skonieski, Karina Raquel Fagundes, Gabriela Sandri, Daniel Barbosa de Chaves, Gabriela Suthovski, Andre Lazarin Gallina, Stifani Machado Araujo, Dalila Moter Benvegnu
Summary: This study evaluated the effects of consuming gummy candies enriched with Konjac glucomannan (KGM) on appetite, anthropometric data, and biochemical markers in overweight individuals. The results showed that participants who consumed KGM for 14 days experienced a reduction in waist circumference and intensity of hunger/satisfaction. Longer consumption and higher doses of KGM are believed to contribute to even more satisfactory body results.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhenyu Li, Ling Zhang, Chunling Mao, Zhiming Song, Xinxin Li, Chun Liu
Summary: This study evaluated composite gels prepared with konjac glucomannan (KGM) and gum arabic (GA) using various analytical methods, revealing gel stratification at certain concentrations, changes in microstructure with GA concentration, and increases in water solubility and water absorption with higher GA concentrations. Rheological analysis showed the gels to be non-Newtonian pseudoplastic fluids with different deformation characteristics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
I. B. Gashua, P. A. Williams, M. P. Yadav, T. C. Baldwin
FOOD HYDROCOLLOIDS
(2015)
Article
Medicine, Legal
Shawna N. Bolton, Michael P. Whitehead, Jayesh Dudhia, Timothy C. Baldwin, Raul Sutton
JOURNAL OF FORENSIC SCIENCES
(2015)
Article
Plant Sciences
Helen J. Millner, Timothy C. Baldwin
Article
Plant Sciences
Melinda Chua, Trevor J. Hocking, Kelvin Chan, Timothy C. Baldwin
AMERICAN JOURNAL OF BOTANY
(2013)
Article
Chemistry, Applied
Melinda Chua, Kelvin Chan, Trevor J. Hocking, Peter A. Williams, Christopher J. Perry, Timothy C. Baldwin
CARBOHYDRATE POLYMERS
(2012)
Article
Agriculture, Multidisciplinary
T. Mahendran, P. A. Williams, G. O. Phillips, S. Al-Assaf, T. C. Baldwin
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2008)
Article
Biochemistry & Molecular Biology
Jenny C. Mortimer, Xiaolan Yu, Sandra Albrecht, Francesca Sicilia, Mariela Huichalaf, Diego Ampuero, Louise V. Michaelson, Alex M. Murphy, Toshiro Matsunaga, Samantha Kurz, Elaine Stephens, Timothy C. Baldwin, Tadashi Ishii, Johnathan A. Napier, Andreas P. M. Weber, Michael G. Handford, Paul Dupree
Article
Plant Sciences
Izabela Potocka, Timothy C. Baldwin, Ewa U. Kurczynska
PLANT CELL REPORTS
(2012)
Article
Plant Sciences
Izabela Dobrowolska, Oliwia Majchrzak, Timothy C. Baldwin, Ewa U. Kurczynska
News Item
Plant Sciences
J. -W. Guo, C. -X. Han, Y. -G. Zhang, Y. -X. Lu, H. -Y. Wang, Y. Wang, T. C. Baldwin, C. -Y. Li, W. -J. Li, H. Shao
Article
Plant Sciences
Qiu-Xiong Yang, Dan Chen, Yan Zhao, Xiao-Yu Zhang, Min Zhao, Rui Peng, Nian-Xi Sun, Timothy Charles Baldwin, Sheng-Chao Yang, Yan-Li Liang
Summary: This study investigated the molecular mechanism of seed dormancy breaking at cold temperatures in Fritillaria taipaiensis and explored the genetic regulation of germination initiated by exposure to cold temperature. The results showed that stratification at 4 degrees Celsius induced an upregulation of gene expression involved in gibberellic acid and auxin biosynthesis, promoting embryo development and seed germination. This study provides valuable insights into the regulation of seed germination in F. taipaiensis and other non-model plant species.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Microbiology
Sheeba Sawant, Timothy C. Baldwin, Habib Khan, Ayesha Rahman
Summary: This study provides the first comparative investigation on the yield and bioactivity of Plectranthus amboinicus leaf extracts at different stages of leaf development. The results show that extracts from the log phase have the lowest minimum inhibitory concentration and exhibit the highest biofilm dispersal and inhibitory activities.
CURRENT MICROBIOLOGY
(2023)
Article
Plant Sciences
Marzieh Motamedi, Morteza Zahedi, Hassan Karimmojeni, Timothy C. Baldwin, Hossein Motamedi
Summary: The objective of this study was to identify native bacterial strains that can alleviate abiotic stress caused by herbicide application and promote plant growth. The researchers isolated bacteria from the rhizosphere of field-grown alfalfa and screened them for various growth-promoting traits. Serratia rubidaea, Pseudomonas putida, and Serratia sp. were found to have the highest potential, with S. rubidaea being the only strain capable of producing auxin. Inoculation of these bacterial strains in alfalfa plants showed beneficial effects in terms of growth and development, especially when combined with Sinorhizobium meliloti.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2023)
Article
Plant Sciences
Wen Chen, Fred L. Stoddard, Timothy C. Baldwin
INTERNATIONAL JOURNAL OF PLANT SCIENCES
(2006)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)