Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ibolya Rutkai, Ivan Merdzo, Sanjay Wunnava, Catherine McNulty, Partha K. Chandra, Prasad Katakam, David W. Busija
Summary: Differences in mitochondrial characteristics, including morphology, respiration, and calcium sparks activity, between male and female rats may contribute to sex differences in protective and repair mechanisms in response to transient ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Siqi Wang, Yuting Chen, Chen Xia, Chunyan Yang, Jian Chen, Li Hai, Yong Wu, Zhongzheng Yang
Summary: Glycosylated quercetin (2Glu-Que) significantly enhances the neuroprotective effects of quercetin by improving water solubility, stability, and cell viability, making it a promising candidate in neuroprotection.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Jennifer D. Sokolowski, Sauson Soldozy, Khadijeh A. Sharifi, Pedro Norat, Kathryn N. Kearns, Lei Liu, Ashley M. Williams, Kaan Yagmurlu, Panagiotis Mastorakos, G. Wilson Miller, M. Yashar S. Kalani, Min S. Park, Ryan T. Kellogg, Petr Tvrdik
Summary: Stroke is a major burden, and despite advances in prevention and treatment, it still negatively affects patients, families, and healthcare professionals. Preclinical basic research, particularly using mouse models, can help to understand stroke pathology and discover effective interventions. This article reviews the middle cerebral artery occlusion technique and introduces various imaging approaches to enhance preclinical stroke evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Konstantinos M. Themistoklis, Themistoklis I. Papasilekas, Konstantinos S. Melanis, Konstantinos A. Boviatsis, Stefanos I. Korfias, Konstaninos Vekrellis, Damianos E. Sakas
Summary: The tifMCAO stroke model in rats is widely used and has been proven to reliably mimic human stroke. The surgical technique has been detailed with stepwise instructions and visual aids provided.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Li-Qin Zhao, Ankit Parikh, Yun-Xia Xiong, Qing-Yan Ye, Ying-Guo, Xin-Fu Zhou, Hai-Yun Luo
Summary: This study assessed the effect and mechanisms of oral edaravone on a rat model of middle cerebral artery occlusion. The results showed that oral edaravone improved sensorimotor functions, reduced cerebral infarction area, and provided neuroprotection by minimizing oxidative stress and alleviating synaptic damage.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maozhu Liu, Mengyuan Chen, Ying Luo, Hong Wang, Haifeng Huang, Zhe Peng, Miaomiao Li, Huizhi Fei, Wen Luo, Junqing Yang
Summary: Celastrol, a compound isolated from traditional Chinese medicine, demonstrates effectiveness in protecting against cerebral ischemia/reperfusion injury. Through lipidomics analysis, it was found that celastrol can reduce cerebral infarct volume and apoptosis, and regulate lipid metabolism to exert its neuroprotective effects.
Article
Plant Sciences
Meijuan Yin, Zhenyi Liu, Jing Wang, Weijuan Gao
Summary: The aim of this study was to investigate the molecular mechanism of Buyang Huanwu Decoction (BYHWD) in attenuating cerebral ischemia-reperfusion (I/R) oxidative damage by activating the PKC epsilon/Nrf2/HO-1 pathway. The results showed that BYHWD improved neural function, reduced neuronal damage, inhibited ROS production, decreased MDA and 8-OHdG levels, increased SOD and GSH-PX activity, and restored mitochondrial membrane potential. BYHWD activated the expression of Nrf2 and PKC epsilon, promoted Nrf2 translocation, and enhanced HO-1 expression. Therefore, BYHWD attenuates oxidative damage and reduces brain I/R injury by activating the PKC epsilon/Nrf2/HO-1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
N. Boulenoir, G. Turc, H. Henon, N. Laksiri, F. Mounier-Vehier, I. Girard Buttaz, D. -L. Duong, J. Papassin, M. Yger, A. Triquenot, A. Lyoubi, A. Ter Schiphorst, C. Denier, J. -C. Baron, P. Seners
Summary: Understanding the incidence, predictors, and mechanisms of early neurological deterioration (END) following intravenous thrombolysis (IVT) for acute stroke with mild symptoms and isolated internal carotid artery occlusion (iICAo) may help guide therapeutic decisions. The location of internal carotid artery occlusion is strongly associated with END, suggesting a different response to IVT. These findings indicate that END may be preventable in this setting.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Behavioral Sciences
Ying Li, Min Gong
Summary: The treatment of cerebral ischemia-reperfusion injury remains a challenge, with GLP-1 receptor agonist Liraglutide showing promising effects in alleviating this type of injury. This study aimed to clarify the physiological protection role of Liraglutide in MCAO mice, revealing that it significantly reduced infarct volume and induced various effects on protein expression levels and phosphorylation. These findings contribute to identifying novel therapeutic targets for ischemia-reperfusion injury.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Priya Jhelum, Mydhili Radhakrishnan, A. R. Sam Paul, Sandeep K. Dey, Avijeet Kamle, Arvind Kumar, Abhay Sharma, Sumana Chakravarty
Summary: Glucosamine has been found to exhibit neuroprotective, antineuroinflammatory, and proneurogenic effects in mouse models of brain injury, potentially enhancing its drug repurposing potential in ischemic stroke.
NEUROMOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zunhua Yang, Gengzhuo Luo, Yuqing Ying, Huilan Li, Yang Wan, Guoliang Xu, Mingdong Li, Yang Xian, Yulin Feng, Yuanying Fang
Summary: There is currently a lack of highly effective and safe drugs for the clinical treatment of ischemic stroke. This study aimed to discover more potent anti-cerebral ischemic agents by designing and synthesizing a series of 2,6-disubstituted benzofuran-3-one derivatives as NBP analogues. Compounds 5 and 16 showed stronger neuroprotective effects than established clinical drugs and exhibited good antioxidative activity without cytotoxicity. Compound 5 also reduced the ischemic infarct area and modulated the expression of inflammatory markers and nerve growth factor in rats.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Gintare Zemgulyte, Shigeru Tanaka, Izumi Hide, Norio Sakai, Katryna Pampuscenko, Vilmante Borutaite, Daiva Rastenyte
Summary: The study demonstrates that post-stroke treatment with metformin exhibits anti-inflammatory and neuroprotective effects in a model of permanent middle cerebral artery occlusion, improving neurological deficits, reducing infarct size, and preventing neuronal loss in the ischemic cortex.
Article
Biology
Beina Chen, Manman Zhang, Ming Ji, Dianjun Zhang, Binjie Chen, Wenliang Gong, Xinyu Li, Yuefei Zhou, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Xiafang Wu, Huiya Yuan, Enyu Xu, Maosheng Xia, Alexei Verkhratsky, Baoman Li
Summary: This study reveals that lithium inhibits the production of reactive oxygen species (ROS) through two signaling pathways, resulting in neuroprotection and improved functional outcomes in ischemic stroke.
COMMUNICATIONS BIOLOGY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)